By Michael Calia and Neetha Mahadevan 

Merck & Co. agreed to sell its consumer-care business, including the allergy-treatment Claritin and nasal decongestant Afrin, to Bayer AG for $14.2 billion.

The deal, which includes collaboration on certain drug development, will allow Merck to focus on therapeutic areas where it feels it is strongest, including drugs for cancer and diabetes as well as vaccines.

Meanwhile, Bayer said the deal makes it the second-biggest seller of over-the-counter products in the world and the biggest one in North America, where the Merck business generated about 70% of its sales last year. Combined, the consumer care divisions of Bayer and Merck had pro forma sales of about $7.4 billion in 2013.

The purchase is Bayer's second-biggest after buying Schering AG for $17 billion in 2006.

"This acquisition marks a major milestone on our path towards global leadership in the attractive nonprescription medicines business," Bayer Chief Executive Marijn Dekkers said. Bayer's consumer-health segment already includes Aspirin and skin care product Bepanthen/Bepanthol.

The move comes amid a wave of pharmaceutical deals as companies look to bolster and retool product portfolios in an effort to focus on their perceived strengths.

Merck, which had said earlier in the year that it was looking to sell the consumer business, expects the deal to close during the second half of this year, with after-tax proceeds of between $8 billion and $9 billion.

Bayer said it plans to finance the deal with a bridge facility provided by Bank of America, BNP Paribas and Mizuho that will be syndicated to a larger group of banks. The company may not be done making deals; it has been speculated that Bayer may look to sell its plastics and chemicals business.

Bayer has made no secret of its ambition to build up its health-care portfolio with bolt-on acquisitions. Last year, it bought Germany's Steigerwald and China's Dihon Pharmaceuticals, two herbal medicine companies. It also recently spent $2.86 billion for Norway's Algeta ASA, its partner on a new prostate cancer treatment.

According to two people familiar with the matter, Bayer outbid privately-held rival Boehringer-Ingelheim for the Merck assets. It also edged out consumer-goods company Reckitt Benckiser Group PLC, which pulled out of discussions last week.

As part of the deal announced Tuesday, Bayer and Merck also agreed to collaborate on the development of therapies for cardiovascular disease, including hypertension drug Adempas, which is marketed in the U.S., Europe and Japan.

The companies will split costs and profits from the collaboration, while creating a joint development and marketing plan, Merck said.

The collaboration also includes the clinical development of Bayer's vericiguat, a treatment for worsening heart failure currently in Phase 2 trials, among other early-stage compounds in development at Bayer. Bayer will receive a $1 billion upfront payment with the potential for additional milestone payments upon certain sales goals, Merck said.

Merck, meanwhile, also will make its early-stage compounds for cardiovascular disease treatment available under similar terms, the company said.

Ever since Merck inherited the consumer business in its 2009 acquisition of Schering-Plough, analysts have speculated that the health-care giant would unload it in some fashion, perhaps through a sale or joint venture.

Merck reported global consumer-care sales of $1.9 billion for 2013, or about 4% of total company revenue of $44 billion. The U.S. accounted for $1.33 billion of the consumer unit's sales total, with international markets contributing $568 million. The biggest product in the portfolio is an over-the-counter version of allergy drug Claritin, which had sales of $471 million last year.

The division also includes MiraLAX constipation medicine, Dr. Scholl's foot-care products, Coppertone sunscreens, and Lotrimin and Tinactin antifungals. In the first quarter that Merck reported last week, sales in the consumer-care segment fell 4% to $546 million.

Merck has been coping with an aging pipeline and competition for its top-selling product, Januvia, and it has suffered several setbacks trying to develop new drugs.

Bayer and Merck are among a handful of major pharmaceutical firms taking part in a frenzy of deal-making activity lately, as the companies seek to bolster their product portfolios.

For instance, Pfizer Inc. has been pursuing its British rival AstraZeneca PLC since November, but AstraZeneca has rejected the advances. Last week, AstraZeneca said Pfizer's most recent cash and stock proposal "substantially" undervalued the company.

Additionally, a handful of complex, multibillion-dollar deals and joint ventures involving Novartis AG, GlaxoSmithKline PLC and Eli Lilly & Co. were unveiled late last month. More broadly in the health-care market, Zimmer Holdings Inc. agreed to pay $13.35 billion for fellow medical-device maker Biomet Inc.

Ben Fox Rubin contributed to this article.

Write to Michael Calia at michael.calia@wsj.com

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