ADVFN - Advanced Financial Network.
HOME» NYSE » M » MRK Stock Price » MRK Stock News

Merck Share News

 Merck & Co., Stock Price
MRK Stock Price
 Merck & Co., Stock Chart
MRK Stock Chart
 Merck & Co., Stock News
MRK Stock News
 Merck & Co., Company Information
MRK Company Information
 Merck & Co., Stock Trades
MRK Stock Trades

J&J's Simponi Helps Colitis Patients In Clinical Trial

By Peter Loftus Of DOW JONES NEWSWIRES Johnson & Johnson (JNJ) said its drug Simponi improved symptoms in a majority of patients with an inflammatory-bowel disease in a new clinical trial. The results, released at a medical conference Monday, could support expansion of the approved uses of Simponi to include treating the bowel condition, known as ulcerative colitis, which J&J estimates affects about 700,000 people in the U.S. Simponi, which was introduced in 2009, is currently approved to treat signs and symptoms of moderate to severe rheumatoid arthritis, active psoriatic arthritis and active ankylosing spondylitis. Simponi is known as an anti-tumor necrosis factor, or anti-TNF, a category that also includes J&J's older drug, Remicade, which is already approved to treat ulcerative colitis. Simponi can be self-administered by patients as an injection, while Remicade requires intravenous infusion by a health-care provider. J&J recorded $410 million in Simponi sales for 2011; Merck & Co. (MRK), which markets the drug in certain countries outside the U.S., recorded $264 million in Simponi sales for 2011. J&J tested Simponi in a late-stage clinical trial of more than 770 patients with moderately to severely active ulcerative colitis who had failed to respond to or tolerate certain other treatments. Some patients received Simponi--at two different dose levels--and some received a placebo, and researchers tracked how many experienced a clinical response at six weeks after the start of treatment. Clinical response included improvements in various symptoms of ulcerative colitis such as diarrhea. According to J&J, 51.8% and 55% of patients in the two Simponi groups, respectively, achieved a clinical response at week 6, versus 29.7% of placebo patients. The results were presented Monday at the Digestive Disease Week medical meeting in San Diego. In a secondary measure in the trial, roughly 18.7% and 17.8% of patients in the Simponi groups had clinical remission, versus 6.3% in placebo patients. The rates of adverse events were comparable among the Simponi and placebo groups, and J&J said the safety of Simponi in the colitis study was consistent with the drug's safety profile in the diseases for which it's already approved. As a class of drugs, Simponi and other anti-TNFs are associated with increased risk of infections and certain forms of cancer such as lymphoma. The data suggest Simponi could be a new treatment option for ulcerative colitis patients who don't respond to other drugs, or who prefer the convenience of a subcutaneous injection, said William Sandborn, chief of the division of gastroenterology at the University of California, San Diego, and lead investigator of the J&J-funded study. J&J also has studied Simponi over a longer treatment duration in colitis patients, and results are expected later this year. J&J plans to apply for U.S. and European regulatory approval of Simponi as a treatment for ulcerative colitis this year, said J&J spokesman Brian Kenney. Abbott Laboratories (ABT) also has applied for regulatory approval of its anti-inflammatory drug, Humira, as a treatment for ulcerative colitis. European regulators have approved the new indication. Last year, the FDA declined to approve J&J's requests to market Simponi's ability to inhibit progression of structural damage in both rheumatoid arthritis and psoriatic arthritis. -By Peter Loftus, Dow Jones Newswires; +1-215-982-5581; [email protected]

Stock News for Merck (MRK)
DateTimeHeadline
01/20/201716:01:00Merck Announces Settlement and License Agreement Resolving KEYTRUDA®...
01/20/201706:01:00Merck and Genea Open Centre of Excellence for Fertility
01/19/201701:30:00MSD for Mothers Commits $10 Million & Bus. Expertise to the Global...
01/18/201709:00:00Merck Foundation Grant Expands Project ECHO® in Vietnam and...
01/17/201716:47:01Statement of Changes in Beneficial Ownership (4)
01/12/201703:03:00Health Stocks Fall as Trump Slams Industry -- WSJ
01/10/201716:06:00Merck Receives FDA Acceptance of Supplemental Biologics License...
01/09/201708:00:00Incyte & Merck to Advance Clinical Development Program Investigating...
01/06/201708:00:00Merck to Participate at the 35th Annual J.P. Morgan Healthcare...
01/04/201715:05:00Pennsylvania Is Ordered to Provide Hepatitis C Drug to Inmate--Update
01/04/201711:32:00Pennsylvania Is Ordered to Provide Hepatitis C Drug to Inmate
01/03/201716:14:49Statement of Changes in Beneficial Ownership (4)
01/03/201716:14:24Statement of Changes in Beneficial Ownership (4)
01/03/201716:14:24Statement of Changes in Beneficial Ownership (4)
01/03/201716:14:24Statement of Changes in Beneficial Ownership (4)
01/03/201706:45:00Merck to Hold Fourth-Quarter and Full-Year 2016 Sales and Earnings...
12/28/201603:02:00Ahead of the Tape: Trump Gives 'Dogs of the Dow' Pause -- WSJ
12/27/201616:28:00Donald Trump Dogs Dow Strategy -- Ahead of the Tape
12/19/201617:52:00Biogen Names New CEO -- Update
12/19/201607:00:00KEYTRUDA® (pembrolizumab) Approved as First Anti-PD-1 Therapy...

Merck and other New York Stock Exchange stock quotes are delayed by at least 20 minutes.
All other stock price data is delayed by at least 15 minutes unless otherwise stated.
By accessing the services available at ADVFN you are agreeing to be bound by ADVFN's Terms & Conditions
Contact Us | Copyright 1999-2016 ADVFN PLC. | Privacy Policy | Investment Warning | Data accreditations | Investor Relations

ADVFNADVFN ItalyADVFN GermanyADVFN FranceADVFN BrazilADVFN JapanADVFN UKADVFN US