By Kate O'Keeffe 

HONG KONG--The world's largest casino operator is losing its leader in Macau amid the worst-ever downturn in the once-booming Chinese gambling hub, which has been hammered by Beijing's crackdown on corruption.

The Macau unit of Las Vegas Sands Corp. said in a statement Friday that its chief executive, Ed Tracy, has decided to retire effective March 6.

Mr. Tracy has no disagreement with the board and will be a consultant to the company after stepping down, according to the statement from the Hong Kong-listed unit Sands China Ltd.

The 62-year-old executive, who joined the casino operator in 2010 and was appointed chief executive in July 2011, said in a Friday letter to staff reviewed by The Wall Street Journal that he and his wife are returning to the U.S. to focus on family and health.

With the opening of The Parisian, Sands' fifth casino in Macau, still more than a year away, "the best management team in Macao already in place and several other important objectives already achieved, this seemed like the right point in time to announce my retirement," said Mr. Tracy in the letter. He didn't immediately reply to a request for comment.

Las Vegas Sands chairman Sheldon Adelson praised and thanked Mr. Tracy in a statement provided by the company's spokesman. As the company looks for a replacement, "we remain deeply committed to the future of Macao and the more than 28,000 team members there who are a part of the Sands family," said Mr. Adelson in the statement.

Shares of Sands China were down 3.0% at HK$36.95 in Hong Kong trading, but outperformed peers like SJM Holdings Ltd. and Galaxy Entertainment Ltd., which both finished more than 4% lower.

The announcement of Mr. Tracy's retirement comes amid a seven-month losing streak in Macau, which last year recorded its first annual decline in gambling revenue since data became available in 2002.

Executives and analysts attribute the sharp reversal of fortunes in Macau, which rakes in seven times more gambling revenue than the Las Vegas Strip, primarily to China's crackdown on corruption. In addition to bringing down many top mainland officials, the sweeping campaign has led high rollers to shy away from Macau's baccarat tables, they say.

Anjie Zheng

contributed this article.

Write to Kate O'Keeffe at Kathryn.OKeeffe@wsj.com

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