By Tripp Mickle 

Shareholders of Reynolds American Inc. and Lorillard Inc. have voted to approve Reynolds' $25 billion acquisition of Lorillard.

The transaction, which combines the country's second largest player in the tobacco industry, Reynolds, and the third largest, Lorillard will still need regulatory approval before it can be completed. The Federal Trade Commission is expected to weigh in later this quarter.

Investors have expressed skepticism the FTC will approve the deal. Lorillard's stock opened Wednesday at $65.77, about 7% below the deal's closing price. Two analysts said the market gives the deal about a 60% chance of closing.

To clear antitrust hurdles, Reynolds struck a deal to sell four cigarette brands and an e-cigarette brand to Imperial Tobacco Group TLC for $7 billion. Shareholders of Imperial on Wednesday are expected to vote on the acquisition of those brands, which will turn the company into the No. 3 player in the U.S., the world's most profitable tobacco market, with a 10% share.

Write to Tripp Mickle at Tripp.Mickle@wsj.com

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