By Peter Loftus 

Drug maker Eli Lilly & Co. reported an 18% decline in second-quarter profit, weighed down by acquisition costs, but its purchase of an animal-drug business helped Lilly squeeze out its first quarterly revenue increase in 18 months.

The revenue growth, up 1% in the quarter, suggests Lilly may be digging its way out of a sales slump in recent years caused by the expiration of patents for one-time blockbuster drugs including the antidepressant Cymbalta and antipsychotic Zyprexa, which triggered competition from low-cost generics. To cope, the company has cut some costs, but it has maintained a relatively high level of research-and-development spending in an effort to generate new drugs.

The Indianapolis company's second-quarter results were better than analysts' expectations, and Lilly raised its forecast of 2015 earnings excluding certain costs. Lilly shares, which have surged nearly 25% year-to-date, were off 0.4% at $86.01 Thursday midday.

"We're doing better on the revenue line," Chief Executive John Lechleiter said in an interview. "Our operating expense came in less than had been forecast. It's all cylinders firing."

Lilly has recently won regulatory approval for several new drugs including cancer treatment Cyramza and diabetes drug Trulicity. But a big reason for the recent gains in Lilly's stock price has been rising investor expectations for certain experimental drugs in the company's research labs, including solanezumab, a potential treatment for Alzheimer's disease; and evacetrapib, a potential new heart drug.

Leerink Partners analyst Seamus Fernandez said that Lilly "remains a pipeline story with several high-probability shots on goal."

On Wednesday, Lilly released clinical-trial data for solanezumab suggesting it helped Alzheimer's patients, but a separate ongoing study due to be completed next year will provide a more definitive answer about whether it works. The effort is still considered risky because the drug failed to provide a benefit in two prior trials, and similar drugs developed by other companies have failed in trials.

Dr. Lechleiter said the solanezumab data were encouraging. He said the drug's mechanism, targeting a substance in the brain known as amyloid, is currently the "best bet" on fighting Alzheimer's.

"While we haven't proven that hypothesis, we're putting together more pieces of the puzzle," he said.

For the second quarter, Lilly said net income fell to $600.8 million, or 56 cents a share, from $733.5 million, or 68 cents a share, a year earlier. The latest quarter included costs related to Lilly's purchase of the animal-health business of Novartis AG. Excluding these and other items, earnings would have been 90 cents a share, well above the 74-cent-per-share mean estimate of analysts surveyed by Thomson Reuters.

Second-quarter sales rose 1% to $4.98 billion from $4.94 billion a year earlier. Lilly said increased product volume and higher prices were mostly offset by an unfavorable impact from a stronger U.S. dollar versus other currencies.

Sales rose for osteoporosis drug Forteo but declined for several other top Lilly drugs including diabetes treatments and the cancer drug Alimta. Sales of animal-health products, which include vaccines for livestock, surged 40% thanks to the acquisition of the Novartis business.

Lilly increased its forecast of 2015 earnings, excluding various costs, by 10 cents a share to a range of $3.20 to $3.30. The company raised the lower end of its revenue forecast range to $19.7 billion from $19.5 billion, and reiterated the upper end of $20 billion.

Lilly also said Thursday it plans to expand a research site in San Diego that will accommodate up to 130 new jobs.

Chelsey Dulaney contributed to this article

Write to Peter Loftus at peter.loftus@wsj.com

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