By Andrew R. Johnson and Saabira Chaudhuri 

KeyCorp shares slumped Thursday as the Cleveland-based regional lender's expenses rose higher than expected in the fourth quarter, overshadowing strong growth in the bank's commercial-loan portfolio.

While improving economic data have raised hopes lending will pick up this year, the banking industry remains under immense pressure to cut costs as low interest rates have crimped revenue and borrowing by consumers and businesses remains tepid.

Key said its costs totaled $712 million in the quarter, more than a previous forecast of as much as $700 million, due to higher-than-expected pension costs, technology projects and other initiatives.

"You can only cut so much until you sort of hit the cutting wall," Nancy Bush, an analyst with NAB Research LLC, said in an interview. "I think they've kind of hit that" wall.

Key's shares were down 4.9% at $13.45 in recent trading, though they are up more than 44% over the last year. Shares of Fifth Third Bancorp., another Ohio-based lender, were down 2.2% at $21.44 on Thursday after reporting results that were relatively in line with expectations.

Key posted a profit of $230 million, or 25 cents a share, in the quarter, up from $203 million, or 21 cents a share, a year earlier. Revenue edged down 0.4% to $1.04 billion.

Analysts polled by Thomson Reuters were expecting income of 24 cents a share on $1.03 billion in revenue.

Key, with $93 billion in assets, has been working to lower expenses over the last two years by closing bank branches, consolidating back-office operations and rolling out new technology, but the bank failed to meet cost targets during the quarter, raising questions from analysts over whether management needs to take more drastic steps to improve the efficiency of its operations.

It appears the bank's progress "stalled in the fourth quarter," Mike Mayo, an analyst with CLSA, said during a conference call with Key's executives.

This year the bank is targeting an efficiency ratio--which measures how much it costs to produce revenue--of 60% to 65%. The lower the efficiency ratio, the better.

Mr. Mayo said 65% is "still a really lousy efficiency ratio."

Beth Mooney, who has been Key's chief executive since 2011, said during the call the target isn't an end-goal for the company but an logical target for the year due to low interest rates, which may continue to constrain revenue growth.

Ms. Bush said Key may benefit from doing acquisitions to beef up its presence in areas of consumer lending and filling in its far-flung physical footprint, which has made it harder to compete against larger rivals.

The bank in recent years has done a handful of deals, including acquiring a portfolio of Key-branded credit-card loans that had been issued by an outside financial institution and buying more than 30 branches in upstate New York from HSBC Holdings PLC's U.S. bank.

While Key has excess capital to deploy that would allow it to do "opportunistic" deals that arise, M&A is "not something that I feel is necessary to complete the equation," Ms. Mooney said.

She, like other bank executives in recent days, said continued economic improvement could lead businesses and consumers to increase their borrowing later this year.

The economy appears to be "on firmer ground" than last year, Ms. Mooney said in an interview.

Key said average loan balances grew 3.4% to $53.61 billion in the quarter, driven by growth in commercial, financial and agricultural loans.

Fifth Third's average loan balances grew 5% from a year earlier to $87.9 billion, also driven by commercial lending.

The Cincinnati-based bank said it earned $402 million in the quarter, up from $399 million a year earlier. Per-share earnings were flat at 43 cents.

Revenue dropped 9.8% to $1.61 billion. Analysts polled by Thomson recently expected per-share earnings of 42 cents on revenue of $1.53 billion.

The bank's results benefited from modestly stronger loan growth and lower expenses, although a key measure of lending profitability continued to decline.

Fifth Third's noninterest expense dropped 15% from the year earlier to $989 million as salaries and employee benefits fell from the fourth quarter of 2012, and the bank benefited from comparison with a year-earlier quarter weighed down by a $135 million charge tied to debt.

"The bigger picture reality is that there are some signs of hope on the revenue side but banks still have to do everything they can to hold the line on expenses," Jefferies analyst Ken Usdin said in an interview.

Write to Andrew R. Johnson at andrewr.johnson@wsj.com and Saabira Chaudhuri at saabira.chaudhuri@wsj.com

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