At Hewlett-Packard Co.'s annual customer conference this week, lab-coated technicians showed off plastic models of memory chips and photonic networking gear beneath rows of brightly lit green rectangles.

The rectangles are the symbol of a new company, HP Enterprise, that will blink into existence when H-P splits in two on Nov. 1. HP Enterprise will target suit-clad corporate buyers, such as those milling about the conference in Las Vegas, while the second splinter, HP Inc., will push PCs and printers.

The hardware on display is part of H-P's plan to build a 21st century supercomputer. The device, called the Machine, is a big bet on the future of computing. It is also a bid to differentiate HP Enterprise from competitors such as Dell and Lenovo Group Ltd. The Machine uses a new form of memory called a memristor, wired using ultrafast photonic fibers instead of conventional copper wires. But current operations won't be the sole source of innovation as Chief Executive Meg Whitman shores up HP Enterprise's offerings to keep pace with corporate buying habits and relentless commoditization.

H-P is back in potential acquisition mode after the disastrous $11 billion tie-up with Autonomy Corp., Ms. Whitman said in an interview Wednesday. And the company recently booted up a venture investment program to gain access to hot Silicon Valley startups "that have a chance to maybe make big changes," she said. "And so maybe we buy them; maybe we make an investment; or maybe we just incorporate them into our solutions."

Ms. Whitman hinted at acquisitions in data storage and next-generation data-center equipment.

"On the hardware side, just as we bought Aruba, there may be some smaller storage companies that we're interested in," she said. "There may be some converged infrastructure," referring to matched-and-tuned packages of hardware.

At a time when server vendors are reeling from Asian competition and cloud computing, HP Enterprise will be resolutely committed to selling rectangular boxes. With 27% of the server market and $3.9 billion in fourth-quarter 2014 revenue, the current H-P is the world's top server vendor according to research firm IDC. It ranks second in storage, behind EMC Corp., and sells a significant amount of networking gear, too.

"We sell a lot of boxes," Ms. Whitman said. "Think about it. When you go into a data center, there are a lot of boxes there. And with the explosion of data, frankly, there's more demand for compute. Not less."

The problem for HP Enterprise is that competition to satisfy that demand is in overdrive. Many of H-P's boxes—the ProLiant line of servers, for example—are caught in a margin-shearing race to the bottom. H-P competes with not only traditional rivals such as Dell Inc. and EMC but also cloud-computing providers such as Amazon.com Inc. and no-frills Asian server manufacturers such as Quanta Computer Inc.

As a result, H-P is a company under siege. Revenues were down 7% during the company's most recent quarter, ended April 30—the 14th decline in the past 15 quarters. Its storage business was down 8%, high-end "business critical" servers dropped 15%, and networking gear dropped 16%.

The one bright spot was the company's Intel-based server business, where revenue grew by 11%, but where margins are razor thin.

To reverse the trend, H-P will need to deliver new features and move into new markets. There are signs that this is beginning to happen. Last month, H-P closed its $2.7 billion acquisition of Aruba Networks Inc., to become a major supplier of the wireless-networking equipment used by mobile phones and tablets in corporations.

The company also will need to develop its cloud-computing services. Ms. Whitman's plan is to focus not on the public cloud—computing resources offered on the open Internet, a market dominated by Amazon and Microsoft Corp.—but on the company's Helion software, which allows customers to set up private-cloud systems on H-P's boxes.

"H-P has a good brand," said Toni Sacconaghi, an analyst at Sanford C. Bernstein & Co. "They have better scope than most companies, a full range of products and solutions. And that's ultimately what they're going to try and use in the marketplace to gain advantage."

When H-P divides, the two companies will be better able to focus on the separate business and consumer markets, Ms. Whitman said. "Over time, they will evolve to different cultures, but the core values will remain the same," she said.

H-P is also going to face $3 billion in restructuring costs as the two companies spin off, the company disclosed during its latest earnings call. It is already in the middle of laying off 55,000 employees, with more to come. As head of the new HP Enterprise, Ms. Whitman will be fighting off her challengers with a smaller army.

Write to Robert McMillan at Robert.Mcmillan@wsj.com

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