By Elizabeth Williamson 

A newcomer to national politics, Carly Fiorina is running for president by trumpeting her business experience--rising from the secretarial pool to the pinnacle of Hewlett-Packard Co. Her first formal day as a candidate showed that tenure will come under tough scrutiny.

In an online chat tied to the formal launch of her Republican campaign, Mrs. Fiorina was asked why the computer company laid off 30,000 workers during her tenure. Another questioner asked why H-P's stock price fell by so much.

Mrs. Fiorina was chief executive at H-P from 1999 until her firing in 2005 amid a board-management slugfest that led to years of upheaval at the Silicon Valley company. She is arguing that experience makes her qualified to lead the charge against what she calls crony capitalism, encourage entrepreneurship and make "tough choices."

"Yep, I got fired," she said in a recent interview before her official announcement. "I'll stand on my record and run on my record all day long."

Whether she can succeed will go a long way toward determining whether Mrs. Fiorina will be a viable candidate in a crowded and well-funded Republican primary field.

"I managed H-P through a very difficult time," she said Monday to questioners on Periscope, a social-media application. "During that period, every single tech company had to make some tough choices. There's nothing worse than telling someone they don't have a job."

Mrs. Fiorina, 60 years old, started her campaign on the same day that another candidate with no experience as a national candidate, retired neurosurgeon Ben Carson also formally entered the GOP primary race. Speaking to a crowd in his home town of Detroit, Mr. Carson talked about his upbringing by an economically struggling single mother and highlighted a work ethic that propelled him to chief of pediatric neurosurgery at Johns Hopkins University in Baltimore.

On Tuesday, former Arkansas governor Mike Huckabee is set to formally start his GOP campaign.

Mrs. Fiorina launched her campaign website with a video of herself sitting on a couch, a setting strikingly similar to Hillary Clinton's 2008 announcement video--except that in her video, Mrs. Fiorina watches Mrs. Clinton's video, then turns off the TV.

"Our founders never intended us to have a professional political class....If you're tired of the sound bites, the vitriol, the pettiness, the egos, the corruption...then join us," she says.

Mrs. Fiorina's website says that during her H-P tenure, the company "doubled revenues; more than quadrupled its growth rate; tripled the rate of innovation, with 11 patents a day."

As CEO, Mrs. Fiorina spearheaded the 2002 takeover of Compaq Computer, which divided shareholders and directors: While it turned H-P into a market leader, it was seen as a risky bet on low-margin personal computers. The battle over whether or not to acquire Compaq pitted Mrs. Fiorina and her allies against a son of an H-P founder.

In the aftermath of the merger, H-P insiders leaked a detailed list of the board's concerns with Mrs. Fiorina's leadership to The Wall Street Journal. She confronted the board over the leaks, and in the ensuing battle, she lost her job. The search for corporate leakers then grew into a corporate spying scandal involving law enforcement.

During Mrs. Fiorina's tenure, H-P stock lost half its value.

"Many tech companies while I was CEO also lost half their value," she said in response to a question in the Periscope chat.

Some critics say Mrs. Fiorina record points to a failure of leadership. "It's an offensive joke that someone with such a poor record running a company wants to be president," said Jean-Louis Gassée, an early H-P executive who went on to become Apple Inc.'s head of Macintosh development and to found Be Inc.

Mr. Gassée, who has followed H-P as an investor and analyst for five decades, attributes Mrs. Fiorina's decision to run for the White House to "chutzpah...no self-awareness, no humility."

Others take a more nuanced view. With the Compaq merger, "Carly was ultimately right, in that, in time, H-P vaulted past Dell and was the undisputed leader in the global market for computers," said Arik Hesseldahl, a senior editor at technology website Re/code, who has covered H-P for 15 years.

H-P today is undergoing a deep restructuring and has shed thousands of additional jobs. Mrs. Fiorina left with tens of millions of dollars in severance.

Mrs. Fiorina hadn't held any full-time private-sector job since leaving H-P a decade ago. Her government experience includes unpaid service on the Defense Business Board, which looked at staffing issues, among others, at the Pentagon; and two years leading the Central Intelligence Agency's External Advisory Board, from 2007 to 2009.

Natalie Andrews contributed to this article.

Write to Elizabeth Williamson at elizabeth.williamson@wsj.com

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