By Joann S. Lublin and Liz Hoffman 

Ralph Whitworth, an activist investor who has served on nearly a dozen U.S. corporate boards, is stepping down as interim chairman of Hewlett-Packard Co. and taking a leave of absence from Relational Investors LLC, the investment firm he co-founded, to focus on his health.

Mr. Whitworth, 58 years old, was diagnosed with throat cancer in April 2013, and treated soon after, according to a person familiar with the matter. That is the same illness J.P. Morgan Chase & Co. Chief Executive James Dimon is battling. A few weeks ago, Mr. Whitworth learned his throat cancer had recurred, and "it's a worse prognosis," the person said.

Relational said co-founder David Batchelder and other senior employees will take on Mr. Whitworth's duties at the San Diego firm. H-P's board, meanwhile, will meet starting Wednesday for several days to discuss appointing a new chairman, according to a company spokesman.

Relational, which manages $6 billion in assets, is among the most prominent names in shareholder activism, in which hedge funds take stakes in public companies and push for changes.

Mr. Whitworth is seen as being more willing than some other activists to collaborate with companies. He prefers to gain board seats and influence decision-making from within, an approach he followed at H-P, Home Depot Inc. and others.

His approach has allowed Relational to engineer big shake-ups. The firm's involvement in home-improvement retailer Home Depot ultimately led to the ouster of Chief Executive Officer Robert Nardelli and the spinoff of the company's wholesale business. Mr. Batchelder served on Home Depot's board for more than four years, stepping down in 2011.

Despite the activist label, Mr. Whitworth is also seen as a steadying force for companies in crisis. In 1999, he was chairman of Waste Management Inc.'s board in the wake of an accounting scandal. He also served as Sovereign Bancorp's chairman during the financial crisis.

Mr. Whitworth first joined H-P's board in 2011 during a period of turmoil and was named interim chairman in April 2013. His resignation comes amid a rare period of stability for the company. Since 2005, three CEOs have departed under fire.

Rather than revive its search for a permanent chairman, H-P could give CEO Meg Whitman the chairmanship, said a person familiar with the company. But that could rankle shareholders, as the last two CEOs to hold both spots were both eventually forced out of H-P. At least one current independent director is also a candidate to succeed Mr. Whitworth, according to another person.

Mr. Whitworth was among the early activists, working with Texas oil man T. Boone Pickens and starting a shareholder advocacy group called United Shareholders Association. After closing the venture, he founded Relational with Mr. Batchelder in 1996.

Mr. Whitworth recently joined an effort of corporate directors, company executives and investors aimed at improving relations between the camps, which have become fraught amid a rise in shareholder activism.

"He was thoughtful and collaborative, but not afraid to let people know when he disagreed with them," said Donna Dabney of the Conference Board, a business and research association that organized the group. "That's exactly who you want in a boardroom."

Activist hedge funds, particularly those built around a charismatic founder, sometimes struggle to transition to a new generation of leaders. Mr. Batchelder has served on 11 corporate boards, including those of five Fortune 500 companies. He isn't currently on any boards, though Relational has the right to appoint him to the board of SPX Corp. under an agreement struck in January with the manufacturer.

Some of Relational's biggest investors expressed concern Tuesday about Mr. Whitworth's health but aren't worried about its effect on the firm.

"We have great confidence in their team to carry on during Ralph's leave, " said Anne Sheehan, director of corporate governance for the California State Teachers' Retirement System, a public pension fund that invests in Relational.

Relational holds stakes in several companies. Last month, it disclosed an 8.5% stake in Manitowic Co. and called for the company to separate its food-service unit from its crane business, which makes construction and hoisting equipment.

David Benoit contributed to this article.

Write to Joann S. Lublin at joann.lublin@wsj.com and Liz Hoffman at liz.hoffman@wsj.com

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