International stocks trading in New York were mixed on Wednesday. The Bank of New York index of American depositary receipts fell 0.06% to 157.55. The European index decreased 0.07% to 154.95, the Asian index improved 0.24% to 152.43, the Latin American index fell 1% to 309.10 and the emerging markets index decreased 0.08% to 303.77. Among the companies with shares that actively traded was GlaxoSmithKline PLC (GSK, GSK.LN).

GlaxoSmithKline PLC (GSK, GSK.LN) downgraded its earnings outlook for the full year, as its second-quarter profits were hit by weak respiratory-drug sales in the U.S., currency moves and a continuing bribery investigation in China. Shares fell 6% to $50.04.

ABB Ltd. (ABB, ABBN.VX, ABB.SK) reported weaker-than-expected second-quarter earnings as the Swiss engineering giant's performance was weighed down by its power systems division. However, total orders were up 13.47% in the quarter to $10.58 billion. Shares rose 1.5% to $23.79.

Write to Tess Stynes at tess.stynes@wsj.com

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