By Laura Stevens 

United Parcel Service Inc. said it has succeeded in raising prices for e-commerce packages without sacrificing growth as it tackles one of its biggest challenges: making e-commerce more profitable.

The Atlanta-based delivery giant said on Tuesday that it did this in part by changing the way it charges for ground packages, pricing them by box size instead of solely by weight, in an effort to get e-tailers to either use smaller boxes or pay up for more space. The company also declined to renew contracts with "a couple of substantial customers" whose business wasn't profitable enough for UPS, Chief Financial Officer Kurt Kuehn said in an interview. He declined to identify them.

Toys "R" Us Inc. was one of the customers UPS parted way with during the quarter, according to people familiar with the negotiations. UPS raised rates, and the retailer moved to FedEx in February instead of paying those increases. It wasn't clear whether Toys "R" Us's business was unprofitable for UPS.

In addition, UPS raised prices across the board and increased fuel surcharges. Improving e-commerce profitability "is a big priority for us, and it's a combination of product design, improved convenience, reduced costs and some revenue management," Mr. Kuehn said.

Revenue for U.S. ground packages grew 5.3% to $6.36 billion in the first quarter. That helped buoy total U.S. domestic-package operating profit, which rose 10.5% to $1.02 billion.

Regarding the box-size price increase, "it's not our goal to just increase costs to customers. It's to have a win-win where they reduce their materials, expense, and we get to reduce our operating expense," Mr. Kuehn said. He said the revenue growth from that pricing change will level out over time.

The results were good news for UPS, which has struggled with inherently less profitable e-commerce deliveries as the company delivers single, lightweight packages to houses scattered throughout a neighborhood. UPS said Tuesday it's increasing the number of Access Point locations--retailers that will accept deliveries of packages for customers to pick up--to more than 20,000 this year, including adding locations in San Francisco, Washington, D.C., and Boston. That saves it money because it can deliver multiple packages to just one stop.

UPS is also continuing its rollout of Orion, a proprietary routing system designed to shave miles off drivers' routes, aiming for 70% of its U.S. drivers to use the system by year-end.

During the quarter, UPS experienced higher growth in business-to-business shipments as UPS targeted the health-care, tech and industrial sectors and benefited from shifting trade patterns as manufacturers increasingly skip the middleman and ship directly to businesses.

UPS also touted big European growth in the wake of FedEx Corp.'s announcement it would acquire Dutch package-delivery company TNT Express NV this month for $4.8 billion. The move was an end run around UPS, which was blocked by regulators from acquiring TNT in 2013 but laid much of the ground work for the deal.

UPS executives say they've moved on but caution FedEx will also face scrutiny. "The FedEx/TNT deal--that is a complex deal and we expect that regulatory agencies will be as stringent on this deal as they have been on previous deals," said Chief Executive David Abney.

UPS is investing almost $2 billion over five years as volume growth in Europe takes off, executives said. The average daily volume of European exports has more than doubled over the past decade, they added, and the company is moving to add more capacity in the market.

International gains were "driven by impressive growth in Europe, up more than 9%, and we expect strong volume growth there to continue," added Mr. Kuehn. Operating profit in the company's international package business increased nearly 14% to $498 million, even as revenue fell 5% due to currency effects.

The company said it has hedged both its exposure to the euro and the British pound for the next couple of years, which should keep results stable.

The full-year outlook remains unchanged, with expected per-share earnings of between $5.05 and $5.30. U.S. package volume is expected to grow about 3%, with revenues growing at a slightly faster pace.

Shares were up 3% in recent midday trading at $100.59.

UPS posted earnings of $1.03 billion, or $1.12 a share, up from $911 million, or 98 cents a share, a year earlier. Revenue grew 1.4% to $13.98 billion. Analysts had expected earnings of $1.09 a share on revenue of $14.27 billion, according to Thomson Reuters.

The company's supply-chain and freight division's operating profit rose 2% to $151 million.

Separately, the company said that Mr. Kuehn is retiring after nearly 38 years with UPS and will be replaced by Richard Peretz, currently the corporate controller and treasurer.

Mr. Kuehn, who has held the title of CFO for eight years, was the company's first investor-relations officer following UPS's 1999 initial public offering. He started with UPS as a driver while still in college.

Mr. Peretz started as a customer-service representative with UPS during college and has held a number of internal leadership positions related to finance.

Write to Laura Stevens at laura.stevens@wsj.com

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