By Anna Prior 

Danaher Corp. said Chief Executive H. Lawrence Culp Jr. will retire next March and will be succeeded by executive vice president Thomas P. Joyce, Jr.

The selection "reflects the culmination of our succession planning process," said Chairman Steven M. Rales, noting that Mr. Culp has held the position for 13 years and has been with Danaher since 1990. Mr. Culp will continue at Danaher in an advisory role into the first quarter of 2016.

Mr. Joyce, meanwhile, has held several positions at Danaher, and has responsibility for Danaher's water quality, life sciences and diagnostics platforms, which collectively represent over $9 billion of annual revenues, the company said.

Separately, the manufacturer reported first-quarter earnings fell 16%, as a gain on the sale of an unconsolidated joint venture a year earlier masked a rise in revenue during the most recent period.

Danaher, which makes testing, diagnostic and medical equipment, has improved revenue in recent years through acquisitions. However, restructuring charges, cost-cutting activities, and weakening economic and market conditions had pressured the company's bottom line.

For the second quarter, Danaher projected per-share earnings of 90 cents to 94 cents, below the 96 cents a share forecast of analysts polled by Thomson Reuters.

Meanwhile, for the quarter ended March 28, Danaher reported a profit of $579.7 million, or 81 cents a share, down from $691.9 million, or 98 cents a share, a year earlier. Excluding a gain on the sale of an investment in Apex Tool Group LLC in the first-quarter of 2013, among other items, earnings rose from an adjusted 75 cents a share a year earlier.

Sales rose 4.9% to $4.66 billion, while core revenues increased 3.5% from the year earlier period.

In January, the company had forecast per-share earnings of 76 cents to 80 cents on core revenue growth of 3%. Analysts were expecting total revenue of $4.67 billion.

Gross margin widened slightly to 52.6% from 52.3%.

Shares of the company, which backed its full-year outlook, closed Wednesday at $73.65 and were flat in after-hours trading. Through the close, the stock has risen 21% in the last 12 months.

Write to Anna Prior at anna.prior@wsj.com

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