By Anora Mahmudova and Sara Sjolin, MarketWatch

Mylan soars on Teva buyout news

U.S. stocks closed mostly lower on Tuesday, with the S&P 500 and Dow industrials unable to extend the previous session's gains.

Investors assessed a barrage of earnings, while M&A activity in the biotechnology industry helped lift the Nasdaq Composite.

The S&P 500 (SPX) closed 3.06 points, or 0.2%, lower at 2,097.34, with seven of its 10 main sectors losing ground. Energy and materials stocks led the losses.

The Dow Jones Industrial Average (DJI) lost 84.94 points, or 0.5%, to settle at 17,949.72, with nearly two-thirds of its 30 components ending lower. Declines in Travelers Companies Inc. and DuPont weighed on the blue-chip index.

The Nasdaq Composite (RIXF) outperformed other indexes, rising 19.50 points, or 0.4%, to 5,014.10, as big gains in biotechnology stocks lifted the index to near record levels.

David O'Malley, chief executive of Penn Mutual Asset Management with $20 billion in assets under management, said that while consensus-beating earnings and M&A activity are providing support, gains were capped by high valuations and worries over economic growth.

"The S&P 500 has been stuck in a range between 2,040 and 2,120 since February, as different forces are pushing and pulling this market," O'Malley said.

"The bullish case for stocks is based on PE [profit-to-earnings ratio] expansion but it is hard to imagine given the drop in earnings, the Fed's tightening plans and global weakness," O'Malley said.

High valuations in the face of deteriorating earnings have been a concern for portfolio managers who question how long the march higher can continue.

"Gains in U.S. equities since the start of 2009 have been largely due to multiple expansion and any further expansion will put equities into dangerous territory," said Jerry Braakman, chief investment officer at First American Trust, a Santa Ana, Calif.-based manager with $1.1 billion in assets.

Multiple expansion occurs when investors are simply willing to pay more for a dollar of earnings.

Earnings:DuPont & Co.(DD) reported a drop in first-quarter earnings, partly due to the impact from a stronger dollar (http://www.marketwatch.com/story/dupont-forecasts-larger-forex-hit-as-sales-slip-2015-04-21). It also said that the strengthening greenback will dent its earnings for the full year more than it initially forecast in January. Shares slid 3%.

Harley-Davidson Inc.(HOG) shares slumped 9.8% after it cut shipment outlook for the year.

Under Armour Inc.(UA) shares slumped 4.8% as sales fell below expectations due to currency volatility and costs related to acquisitions.

Travelers Cos.(TRV) shares dropped 4% after it said first-quarter profit fell from an unusually strong period a year earlier.

Teva Pharmaceuticals Industries Ltd. (TEVA) said Tuesday it is offering to buy Mylan N.V.(MYL) for $82 a share in cash and stock. Mylan shares jumped 8.9%%, while Teva shares rose 1.4%.

For more on today's notable movers read Movers & Shakers column (http://www.marketwatch.com/story/yahoo-verizon-chipotle-yum-earnings-in-focus-2015-04-21).

Other markets: Japanese and Chinese stocks closed firmly in positive territory, and Europe followed suit with solid gains.

Greece's Athex Composite Index , however, bucked the positive trend and slumped 3.3% amid fears the country is running out of cash.

Read: Charts show current version of Greek crisis nothing like 2012, so far (http://www.marketwatch.com/story/charts-show-current-version-of-greek-crisis-nothing-like-2012-so-far-2015-04-21).

The European Central Bank is now looking at measures to rein in support for Greek banks (http://www.marketwatch.com/story/ecb-looking-at-reining-in-support-for-greek-banks-reports-2015-04-21) under its emergency liquidity assistance, according to a Bloomberg report on Tuesday.

See: Investors may be ignoring potential "collateral damage" from Greece (http://www.marketwatch.com/story/investors-may-be-ignoring-potential-collateral-damage-from-greece-2015-04-20).

Oil (CLK5) settled 2% lower (http://www.marketwatch.com/storyno-meta-for-guid) at $55.26 a barrel. Gold futures (GCK5) reclaimed the $1,200 level, settling 0.8% higher at $1,203.10.

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