By Kris Maher And Russell Gold 

The crude-oil train that derailed and exploded in West Virginia on Monday consisted of modern tanker cars the rail industry has hailed as safe, ratcheting up the debate over proposed federal rules that could require even stronger safeguards.

The derailment near Mount Carbon, a small community outside the state capital of Charleston, launched fireballs into the sky, sent crude into a river and fueled fires that were still burning Tuesday.

One person was treated for possible respiratory problems and released, according to CSX Corp., which operated the train, and one home burned to the ground. Several hundred people were evacuated and many were unable to return to their homes Tuesday. State officials initially said at least one tanker car had fallen into the Kanawha River, but Tuesday they said that no longer appeared to be the case.

The amount of crude oil moving on the nation's railroads has skyrocketed in recent years. In 2009, U.S. railroads transported about 21,000 barrels of oil a day. Today they carry more than 50 times that amount, according to federal data, as fracking-fueled oil production in North Dakota outpaced pipeline capacity and trains became the easiest way to get crude to refineries.

At the same time, a spate of crude-oil explosions has frightened people who live along tracks and caught the attention of regulators. In the most serious incident, a train derailed in Lac-Mégantic, Quebec, killing 47 people.

Federal regulators last year proposed rule changes to make crude-oil transport by rail safer. The White House is considering the changes, according to a Federal Railroad Administration spokesman, and is expected to issue final rules in coming months.

One proposed version of the rules required using the same CPC-1232 tanker cars that exploded in West Virginia. Another version would require a stronger tank car. Tank-car manufacturers support requiring thicker shells and other protections, but the oil industry worries that implementing changes too quickly could slow the U.S. energy boom.

"We think we can reduce the magnitude of these incidents, in part with a safer tank car," said Jack Isselmann, a senior vice president of Greenbrier Cos., an Oregon-based tanker-car maker. But he said orders were slow because leasing companies were waiting for the final federal rule, expected to set standards for new tank cars as well as a timetable for retrofits.

The train that derailed was traveling from North Dakota to Yorktown, Va., a CSX spokesman said.

Most of the oil carried by rail originates in North Dakota, but the exact routes aren't disclosed. Rail companies including CSX have filed lawsuits to prevent states from publicizing them.

However, a Wall Street Journal analysis of state data created a detailed picture of how crude oil moves through this new virtual pipeline. The train that derailed came through Chicago, then headed south through Ohio and into West Virginia. It was scheduled to cross Virginia and deliver about 70,000 barrels of crude to a terminal in Yorktown. In April, a CSX train on the same route derailed in Lynchburg, Va.

Monday's derailment and explosions terrified local residents. Morris Bounds Jr., a 44-year-old general contractor, said he was sitting in his living room in Mount Carbon when he heard a series of booms that shook the ground like an earthquake.

His father, who lives 400 yards away, called and frantically told him a train had derailed next to his house.

Mr. Bounds hopped in his pickup truck and sped toward his father's home. Before he got there, he saw his father running barefoot through the snow. Behind him, flames were leaping from spilled-over tanker cars, and his father's home was already burning.

"It was like a horror movie trying to get to him," Mr. Bounds said. "I had seen cars piled up and flames shooting through them. He was just running for his life."

Mr. Bounds said he was relieved his mother wasn't in the house. She is recovering from heart surgery and was readmitted to the hospital with the flu, Mr. Bounds said, adding that he believed had she been in the house, she would have died. He said she was glad to be alive but upset at having lost all her possessions.

Within a minute or so of driving away, the two men saw the tankers begin to explode, sending shock waves through the air and huge balls of flames that rose against the mountains.

"Everything they owned was there," he said of his parents' home. But, he added: "I got him out of there safely."

Write to Kris Maher at kris.maher@wsj.com and Russell Gold at russell.gold@wsj.com

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