By Anna Mathews 

UnitedHealth Group Inc. plans to acquire Catamaran Corp. for about $12.8 billion in cash, bulking up its pharmacy-benefit business as spending on cutting-edge drugs is a growing concern for employers and insurers.

Catamaran, the fourth-largest pharmacy-benefit manager in the U.S. by volume of prescriptions processed, will be merged into UnitedHealth Group's OptumRx unit, the industry's third-largest player and part of the Optum health-services arm of the health-care giant.

UnitedHealth will pay $61.50 per share of Catamaran, a 27% premium over Friday's closing price of $48.32. The companies said they expect the deal to close in the fourth quarter.

Pharmacy-benefit managers typically work for employers and health plans, managing the pharmacy benefits and seeking to negotiate favorable prices with pharmaceutical companies and drugstores. The two companies are betting that their combined size will generate increased negotiating heft and economies of scale, as they compete with Express Scripts Holding Co., the biggest in the industry, and CVS Health Corp., the No. 2.

"You have to have scale," said Mark Thierer, the chief executive of Catamaran who will be chief executive of the new combined PBM. "This makes the business more competitive overall." The companies said that OptumRx already has been using a technology platform from Catamaran, easing the operational transition.

Catamaran had $21.58 billion in revenue last year, while OptumRx had $31.98 billion. OptumRx expanded sharply when it took over pharmacy benefits for UnitedHealth's insurance unit, UnitedHealthcare, in 2013. Both companies have been growing recently, though Catamaran in February announced the loss of two health-plan clients, putting pressure on its shares despite fourth-quarter earnings that beat analysts' expectations.

UnitedHealth said the deal would be accretive to its net earnings by about 30 cents a share in 2016. The company also said it affirmed its $6- to $6.25-a-share earnings outlook for 2015.

The deal will be the latest consolidation in the pharmacy-benefit sector. Catamaran was known as SXC Health Solutions Corp. until 2012, when it took its current name as it completed a merger with Catalyst Health Solutions Inc. Express Scripts acquired former rival Medco Health Solutions Inc. in 2012.

The industry is focused on reining in costs associated with specialty medicines like new treatments for hepatitis C. Prescription-drug spending rose more than 12% last year in the U.S., the biggest annual increase in more than a decade, according to a report by Express Scripts. The increase was driven partly by the hepatitis C drugs, as well as price increases for some diabetes and cancer medications. The boost came after years when growth was muted by the introduction of generic versions of popular drugs.

Insurers and employers are bracing for the prices tied to expected new treatments for cancer and other conditions such as elevated cholesterol. Pharmacy-benefit managers are eager to show they have tools to counter those costs on behalf of clients.

If the OptumRx deal with Catamaran is consummated, each of the big-three PBM players would offer a different setup. Express Scripts has the largest volume in the industry. CVS has its own network of pharmacies.

The new OptumRx would pitch the benefits of analysis and data, including the broad array of health information that Optum's other businesses glean and crunch. "These capabilities can all be combined with the pharmacy side," said Larry C. Renfro, the chief executive of Optum and vice chairman of UnitedHealth Group.

The companies said they hoped to improve patients' adherence to their drug regimens, and executives pointed to deals like one recently reached by Catamaran, which tied payment for hepatitis C drugs to patients' results.

Executives from Catamaran and UnitedHealth said their customer groups should mesh well. But Catamaran currently has clients that are rivals of UnitedHealthcare. For instance, in 2013 Catamaran struck a 10-year deal to help handle pharmacy-related matters for Cigna Corp. Mr. Thierer said he expected that Catamaran's health-plan customers would "see the benefit they will get from this relationship on all different levels."

Write to Anna Mathews at anna.mathews@wsj.com

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