By Chris Dieterich 

U.S. stocks fell Monday as uncertainty about China's growth injected caution into global markets.

The Dow Jones Industrial Average slid 85 points, or 0.5%, to 17193 in afternoon trading. The S&P 500 shed 17 points, or 0.8%, to 1994 and the Nasdaq Composite Index declined 61 points, or 1.4%, to 4517.

Stocks' cautious tone began overnight, after China's financial minister said major changes to the country's economic stimulus efforts aren't likely even as the world's second-largest economy grapples with growth concerns. That statement damped hopes for more aggressive policies and pushed Treasurys higher, while driving copper and nickel lower. China is a key consumer of base metals.

The yield on benchmark 10-year Treasury notes to 2.567% from 2.589% late on Friday. Treasury yields fall when prices rise.

Shares of Caterpillar, a bellwether maker of mining and construction equipment, tumbled 1.5% and was among the biggest decliners on the Dow.

Yousef Abbasi, a market strategist at brokerage JonesTrading Institutional Services, said that selling in emerging-market stocks helped fuel the market's downbeat mood. The iShares MSCI Emerging Markets exchange-traded fund dropped 1.7% to a 3 1/2 -month low.

Mr. Abbasi said Mondays' action was the work of short-term traders reshuffling positions after last week's full slate of events that included a rate decision by Federal Reserve officials, a vote on Scottish independence and the trading debut of Chinese e-commerce company Alibaba Group.

The Dow rose 1.7% last week and closed Friday at its 18th record high of 2014.

"Today there is a lot of reflection, and people are digesting last week's moves," Mr. Abbasi said, noting a preference on the part of traders in recent days for shares of the largest U.S. companies. The Russell 2000 index of small companies fell hardest on Monday, dropping 1.5%.

Concern about Chinese growth has ramped up in recent weeks after data showed the country's industrial output growth slowed to its lowest level since the 2008 financial crisis. Due on Tuesday is an initial reading on September's Chinese manufacturing activity from HSBC.

Hong Kong's Hang Seng Index dropped 1.4%, while Japan's Nikkei fell 0.9%. In Europe, the Stoxx Europe 600 index fell 0.5% and the U.K.'s FTSE 100 declined 0.9%.

U.S. stocks continued lower after a reading on August existing home sales showed a monthly decline for the first time in five months

Alibaba Group declined 4% on Monday after shares soared 38% in the company's initial public offering on Friday.

Apple edged down 0.2% after the company announced it sold more than 10 million of its new iPhone 6 and iPhone 6 Plus devices over their first weekend.

Traders have been building protective positions in recent weeks as stocks climbed back to all-time highs, said Stacey Gilbert, head of derivatives strategy at Susquehanna Financial Group. She said that prices for "put" options on the S&P 500 index, contracts that are used to hedge against stock-market declines, have risen above those of bullish "call" options.

"Investors are certainly protective as we head into the end of the year, " Ms. Gilbert said.

Still, most long-term investors contend that the outlook for stocks remains positive even after a 3.9% advance for the Dow in 2014. "The reality is that [the economy is] growing, interest rates are low, companies are growing their profits and stocks are at fair value," said John Fox, director of research at Fenimore Asset Management, a $1.9 billion firm in Albany, N.Y. Mr. Fox said his firm has stepped into the market this year to buy shares lagging companies that look underpriced, including retailers.

Mr. Fox conceded that with indexes at all-time highs, it has become harder to find stocks that look reasonably priced.

"It's hard to find discounts," he said. "We're busy meeting with companies trying to find stuff that's cheap."

In commodity markets, crude-oil futures declined 0.9% to $90.82 a barrel. Gold futures rose 0.1% to $1,217.60 a troy ounce. The dollar fell against the euro and yen.

In deal news, German pharmaceutical company Merck KGaA said Monday it agreed to acquire Sigma-Aldrich Corp. for $17 billion. Shares of Sigma-Aldrich jumped 34%.

Germany's Siemens AG said it agreed to acquire Dresser-Rand Group Inc., a U.S. oil-equipment maker, in a deal worth $7.6 billion, or $83 a share in cash. Shares of Dresser-Rand Group rose 2.7%.

EMC Corp. is considering options that could include a merger, The Wall Street Journal reported. EMC is under pressure to break up from hedge fund Elliott Management Corp. EMC shares added 1.2%.

Write to Chris Dieterich at chris.dieterich@wsj.com

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