By Jesse Newman 

A ConAgra Foods Inc. unit agreed to pay a record fine and plead guilty to a federal misdemeanor charge stemming from a 2006-2007 salmonella outbreak. The rare criminal case spotlights how stepped-up enforcement of food-safety laws is shaking up the industry.

ConAgra Grocery Products LLC will pay $11.2 million to resolve allegations that the company shipped contaminated peanut butter under its Peter Pan brand and Wal-Mart Stores Inc.'s Great Value label. The salmonella contamination sickened more than 700 people.

The fine--the largest ever levied in a food-safety case--marks the latest in a string of successful efforts by the Justice Department to hold food companies or their executives accountable for outbreaks of foodborne illnesses that, added together, have sickened thousands.

Since 2013, the Justice Department has won convictions or guilty pleas in four criminal cases against food companies or the executives that ran them. All of the cases fell under the 1938 Federal Food, Drug and Cosmetic Act. By contrast, that is roughly the same number of convictions or guilty pleas as the agency landed under the same act in the 24-year-period from 1988 through 2012.

In most of the recent cases, the Justice Department has successfully prosecuted defendants for introducing contaminated food into the market even without proof that officials acted with criminal intent--a nuance that has jolted the food industry, given its broad implications.

The agency's actions have sparked greater awareness in corporate boardrooms and many companies have stepped-up efforts to bolster food safety, according to industry executives and lawyers. Some companies have invested in new technologies to prevent the build-up of bacteria in plants and to enhance and speed up data collection and analysis.

"It's a sea change," said James Neale, a Virginia attorney who represents food manufacturers and retailers in foodborne-illness cases, but wasn't directly involved in the recent federal criminal cases. "Everyone is paying closer attention to food safety."

It is widely agreed that tougher enforcement is one of several factors increasing food makers' vigilance. New safety rules from the Food and Drug Administration are also contributing.

Among the Justice Department's other recent prosecutorial successes in food safety:

Last year, a federal jury convicted the former owner of a Georgia peanut-processing company, Peanut Corp. of America, and three ex-employees of felony conspiracy and other charges following a 2008-'09 salmonella outbreak that was tied to nine deaths and sickened more than 700 others.

Last month, two executives at a large egg producer were sentenced to prison for their roles in a 2010 salmonella outbreak.

In 2014, two Colorado brothers were sentenced to five years' probation after pleading guilty to misdemeanor charges following a 2011 listeria outbreak that resulted in 33 deaths linked to their farm's cantaloupes.

Stuart Delery, acting associate U.S. attorney general, said the gravity of recent outbreaks of food-borne illnesses focused his attention on addressing threats to food safety soon after his arrival at the Justice Department's civil division in 2012. American families "are relying on us and on food companies to make sure their products are safe to eat," he said in an interview. "The [current] state of affairs is unacceptable."

The enforcement efforts come amid several recent voluntary recalls, including by Blue Bell Creameries LP, which last month pulled all its ice-cream products from grocery store shelves because of a listeria outbreak. And in April, Jeni's Splendid Ice Creams recalled all of its products after listeria was discovered in one of its desserts--an action that some food-industry consultants point to as a sign food companies now are taking more precautions. The company has since resumed making ice cream.

ConAgra in 2007 pulled its peanut butter from store shelves after the salmonella outbreak--which sickened people in 47 states--was traced to the company's Sylvester, Ga., plant. But ConAgra admitted as part of Wednesday's plea agreement that it had been aware of some risk of contamination prior to the recall. The government alleged that ConAgra had earlier shipped from Georgia to Texas peanut butter produced under conditions in which it may have become contaminated with salmonella. Routine product testing on two occasions in 2004 had revealed what later was confirmed to be salmonella in samples of finished peanut butter, according to the government.

After the outbreak, the government said ConAgra made significant upgrades to its plant, and instituted enhanced safety protocols for manufacturing, testing and sanitation.

"We did not, and never will, knowingly ship a product that is not safe for consumers," said Dr. Al Bolles, chief technical and operations officer for ConAgra Foods, in a news release on Wednesday.

Last year, an internal email trail helped government attorneys convince a jury that Stewart Parnell, the former owner of Peanut Corp. of America, had presided over a multiyear scheme to conceal that many of the firm's products were contaminated with salmonella. The government said Peanut Corp. for years failed to notify customers when laboratory tests revealed traces of salmonella in its products.

In some cases, company officials fabricated lab results, stating peanut products were safe for consumption when tests showed otherwise, or when products had never been tested at all, according to court papers.

One internal email suggested Mr. Parnell's desperation after learning that shipment of an order would be delayed because test results weren't yet available for a batch of peanut products. "S---, just ship it," he wrote, according to court papers. "I cannot afford to loose [sic] another customer."

The verdict in the Peanut Corp. case could result in a lengthy prison sentence and fines. Mr. Parnell's lawyer has filed a motion for a new trial.

Tom Bondurant, Mr. Parnell's lead attorney, declined to comment on Wednesday. Participants in the case are under a gag order imposed by a federal judge.

Government attorneys levied felony charges--a rare move in food-safety cases--against Mr. Parnell because they felt they could prove criminal intent, according to food-safety lawyers.

Other cases may represent a more significant development for food companies, the lawyers said, with two pairs of executives recently convicted of misdemeanor crimes even without proof of intent.

In April, a federal judge sentenced a former Iowa egg magnate and his son to three months in prison and payment of $100,000 in fines for misdemeanor violations linked to a 2010 salmonella outbreak that sickened thousands of people and prompted the recall of a half-billion shell eggs.

Austin "Jack" DeCoster and his son Peter DeCoster, each pleaded guilty to one count of selling contaminated food across state lines. The DeCosters ran Quality Egg LLC.

Lawyers say the prison terms for the DeCosters reflect the resurrection by prosecutors of a little-used legal doctrine to impose "strict liability"--through which guilt can be ascribed regardless of whether there was intent to violate the law--against an individual rather than a corporate entity.

Attorneys for the DeCosters have appealed the sentences. "Where there was no criminal intent, does the penalty fit the crime?" said Stuart Dornan, the younger Decoster's attorney. "While Peter has great concern and sympathy for the victims, he didn't know his eggs had any salmonella in them."

Write to Jesse Newman at jesse.newman@wsj.com

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