By Corrie Driebusch 

Stock markets from the U.S. to Europe to China took a beating on Friday on fresh fears about Greece and wobbly corporate earnings, with the Dow Jones Industrial Average giving up all but 3.23 points of its gains for 2015.

Greece's international creditors signaled they are losing hope that Athens will do what is needed to unlock bailout funds before it runs out of money. Prices of Greek government bonds plunged as concern increased about default and an exit from the eurozone, which many analysts believe would hurt European banks and further slow economic growth.

U.S. Treasury Secretary Jacob Lew said that Greece's new government is running out time to reach an emerging-financing agreement. "Not reaching agreement would create immediate hardship for Greece and uncertainties for Europe and the global economy more broadly," he said.

Finance ministers and central bankers from the Group of 20 leading economies warned Friday about an uneven global economic expansion, expressing particular concern about emerging-market economies.

Adding to investor unease were worrisome corporate earnings developments in the U.S., led by card giant American Express Co., and news of new trading restrictions in China following this year's stock-market run-up there.

The declines highlight the vulnerability of global stocks following a roaring 2015 in Europe and parts of Asia, and a yearslong rally in the U.S.

The Dow fell 279.47 points on Friday, or 1.5%, to 17826.30, its biggest one-day percentage drop since March 25, snapping a two-week winning streak for the index.

Before Friday's slump, the blue-chip index was up 1.6% this year. It is now up only 3.23 points on the year, or 0.02%, following a 7.5% advance last year and a 26.5% gain in 2013.

The S&P 500 declined 23.81 points, or 1.1%, to 2081.18, and the Nasdaq Composite fell 75.98 points, or 1.5%, to 4931.81.

"It's weak today, but the markets were at lofty levels," said Stephen Carl, head equity trader at Williams Capital Group. He described Friday's drop as steep but not involving any panic selling.

Many investors remain bullish on stocks, reasoning that growth is picking up in Europe and that the U.S. expansion is entering its seventh year. Ultralow bond yields, driven by expansive central-bank policy, make stocks look more attractive by comparison, these bullish investors say.

But price-to-earnings multiples are above long-term averages and many traders say a sharp decline in oil prices and the rise of the dollar will continue to hit U.S. corporate profits. Some said stocks could pull back before continuing their ascent.

"The earnings picture is starting to degrade materially, and that's making the stock market look expensive," said Frank Barbera, co-portfolio manager at Sierra Investment Management, which manages $1.8 billion. "Earnings are certainly going to be in the spotlight going forward."

American Express fell 4.4% after saying its results were hurt by the strong U.S. dollar, which reduced revenue booked in other countries. Advanced Micro Devices Inc. tumbled 10% after saying its first-quarter loss widened as revenue slumped.

The Stoxx Europe 600 index dropped 1.8%, its largest one-day decline since early January, mirroring declines in other major indexes across the continent. The Stoxx was up 20% for the year through Thursday's close after lagging behind U.S. indexes in the previous two years. Both the Stoxx and the Dow have surged to new records this year.

European bond yields tumbled again to their lowest level on record, underscoring strong demand for safe assets and the continuing impact of European Central Bank bond purchases. The yield on the 10-year German bund, the benchmark for portfolio managers and consumer loans across Europe, slumped to 0.07%, putting the debt within reach of a negative yield for the first time. Low bond yields mean higher prices.

The yield on Greece's 10-year bonds was at 12.49%, close to a two-year high, while two-year yields were at 26.28%, close to their highest since being issued. Yields rise as bond prices fall.

The existence of an inverted yield curve, where shorter-term debt yields more than longer-dated bonds, suggests that investors foresee a very high risk of default.

"There are concerns about the stability of Europe, and we're approaching some very critical dates here with Greece," said James Liu, global market strategist at J.P. Morgan Asset Management.

Poul Thomsen, head of the IMF's European department and one of the chief architects of Greece's bailouts, said: "There is undoubtedly a need for the negotiations to gain notably further momentum in the coming days and weeks in order for us to conclude a review in a timely manner."

The worries about Greece come as global growth is facing fresh headwinds.

The G-20 acknowledged concerns that likely Federal Reserve tightening could send shock waves through markets around the globe. "In an environment of diverging monetary policy settings and rising financial-market volatility, policy settings should be carefully calibrated and clearly communicated to minimize negative spillovers," the group said.

Exacerbating Friday's stock selloff were fears surrounding China. The country's securities regulator issued a strong warning about its stock market and tightened rules on margin lending. Buying stocks with borrowed money has been a major driver of China's stock-market run. The main market has doubled in the past 12 months, and the riskiest index is up 70% this year.

Chinese stocks slumped more than 5% in post-close trading, weighing on sentiment in Europe.

"From my perspective, it's healthy for the market that Chinese regulators are trying to curb margin trading," said Michael Emery of Rainier Investment Management, which manages $6.1 billion. "Speculation in the Chinese market was getting too high."

Josie Cox contributed to this article.

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