By Saabira Chaudhuri 

American Express Co. said it would eliminate 4,000 jobs later this year, but the company's cost cutting isn't moving fast enough for some investors.

The New York credit-card firm is struggling to meet revenue targets in a competitive environment, and an uptick in the company's expenses in the fourth quarter worried some that a crucial advantage for the company in recent years may be fading.

AmEx of late has been falling short of its longtime revenue-growth target of 8%, but the company has been able to meet earnings expectations, in part by controlling expenses.

On Wednesday, Amex shares fell about 2% in after-hours trading as the company disclosed a 3% increase in its expenses as part of its quarterly earnings report. Amex's revenue and profit increased, but not enough to satisfy investors who have grown increasingly demanding of the company's results as the economy grows, consumers repair their balance sheets and more people switch from using cash or checks to plastic.

For Amex's fourth quarter, a stronger dollar, a weak December for retail sales and the sharp drop in gas prices also took a toll on the company's results.

Various "headwinds present a challenging environment for American Express," wrote Jefferies analyst John Hecht in a note following the company's report. Mr. Hecht mentioned that the so-called discount rate, which AmEx collects on each transaction from merchants, edged lower in the quarter, evidence of the short-term costs associated with the company's attempts at expansion.

The layoffs disclosed Wednesday, affecting about 6% of American Express's 63,000 workforce, are part of a broader restructuring to boost efficiency, company officials said on a conference call to discuss the results.

The New York-based credit-card company, run by Chairman and Chief Executive Kenneth Chenault, reported an 11% rise in quarterly profit after the close.

Fourth-quarter profit was $1.45 billion, or $1.39 a share, compared with $1.31 billion, or $1.21 a share, a year earlier. Revenue, net of interest expense, rose 6.6% to $9.11 billion from $8.55 billion a year earlier, helped by a gain on the sale of American Express's investment in Concur Technologies, an expense-management software company.

Analysts surveyed by Thomson Reuters expected a profit of $1.38 a share on revenue of $8.53 billion.

While some analysts had expected AmEx to show strong expense controls, the company reported that companywide expenses came in at $6.3 billion, up 3%, or 6% when adjusted for foreign-exchange impacts, from a year earlier.

Another sign that the company hasn't cut sharply enough for some investors: Despite layoff announcements that approach 12,000 positions over the last two years, Amex's overall headcount has remained relatively steady between 61,000 and 63,500 since 2010, according to the firm's annual reports.

Amex said that it had used a big part of the gain on its Concur sale on restructuring initiatives. That may lead to cost savings later, but in the fourth quarter, it led to a pretax charge of $313 million.

"A substantial gain allowed us to accelerate some critical initiatives: re-engineering to make American Express more efficient," said Mr. Chenault in prepared remarks.

American Express also spent more during the period on marketing and promotion and renewing its partnership with Delta Air Lines. The company is revving up partnerships with merchants, from Apple Inc. to McDonald's Corp. to Uber to promote mobile payments and its rewards programs.

The company, which issues credit and charge cards and owns a processing network, said card-member spending rose 6%, while U.S. loan balances increased 7%. The provision for loans that could sour came in at $582 million, up 22% from a year ago.

While officials described the consumer-credit environment as strong, the company suffered from lower spending on gasoline purchases and the strengthening of the dollar.

"We've made very good progress against the backdrop of an uneven global economy and the negative impact of a strengthening U.S. dollar," said Mr. Chenault on Wednesday, even as he cautioned that the company faces "competitive and regulatory challenges."

Also Wednesday, Discover Financial Services posted a 7% increase in fourth-quarter net interest income, but revenue declined and earnings fell below analysts' estimates due in part to changes in the company's customer-rewards program.

Discover reported a profit of $404 million, down 33% from $602 million a year earlier. On a per-share basis, earnings were 87 cents, down from $1.23. Earnings excluding items were $553 million, or $1.19 a share.

Analysts polled by Thomson Reuters had projected earnings of $1.30 a share on revenue of $2.2 billion. These estimates generally exclude nonrecurring items.

Shares fell about 3% in after-hours trading.

Revenue, net of interest expenses, fell 4% to $2.04 billion from $2.13 billion a year ago, reflecting a charge related to a simplification of the company's Cashback Rewards program. The total fell short of the $2.2 billion analysts expected, on average.

The change involves the elimination of Discover's credit-card rewards forfeiture reserve and will make rewards easier for customers to redeem. Overall, the company said in November it would post about $178 million of fourth-quarter charges related to the change.

"We think the changes will be beneficial for our company and have been receiving favorable feedback from our card members," said Chief Executive David Nelms.

Robin Sidel and Daniel Huang contributed to this article.

Write to Saabira Chaudhuri at saabira.chaudhuri@wsj.com

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