By Razak Musah Baba 

Teva Pharmaceutical Industries Ltd. on Monday said it would buy Allergan PLC's generics unit for $40.5 billion in cash and stock, in a deal that will vault the Israeli company into the top ranks of global drug makers.

Teva said Allergan would receive $33.75 billion in cash and Teva shares valued at $6.75 billion, giving it a 10% stake in Teva.

"This transaction delivers on Teva's strategic objectives in both generics and specialty," Teva Chief Executive Erez Vigodman said.

The deal, the latest in a wave of consolidation in the drug industry in recent years, combines Teva, the world's largest generic-drug company by sales, with the third-largest competitor in the market.

The acquisition will give Teva increased scale in the hotly competitive generic-drug market, and an opportunity to pursue further cost reductions that could help it cope with the end of a wave of big patent expirations.

In a separate statement, Teva said that as a result of the Allergan deal it would drop its bid for rival Mylan NV.

Teva said it expected the acquisition of Allergan Generics to contribute $2.7 billion in earnings before tax depreciation and amortization, or Ebitda, in 2016, excluding synergies. It expects to achieve cost synergies and tax savings of approximately $1.4 billion annually, largely achievable by the third anniversary of the closing of the transaction.

Teva said the transaction was unanimously approved by the boards of both companies and is expected to close in the first quarter of 2016.

Midsize companies such as Teva have largely driven the breakneck pace of consolidation in the drug industry in recent years--part of a broader boom in mergers and acquisitions--as they take advantage of cheap debt and in some cases low tax rates secured by relocating overseas, while drawing on the approval of investors who have driven their shares higher. Meanwhile, bigger, more-established rivals have largely been on the sidelines of major deal making.

Last year Teva, which had a market value of $60 billion before The Wall Street Journal reported on the possible deal Saturday, had $9.1 billion in generic-drug sales, according to EvaluatePharma, about 12% of the world market. The company said it already accounts for one in six drug prescriptions in the U.S. But much of its business is in no-name generic medicines sold at lower prices. Nearly half of Teva's $20.3 billion in sales last year were from the off-patent generic copies of drugs.

By adding Allergan's business, which reported $6.6 billion in sales last year, Teva would have revenue significantly greater than that of better-known, branded-drug companies such as Cialis maker Eli Lilly & Co., which reported $19.6 billion in sales last year.

The deal could give the combined company a market value exceeding that of Lilly, which stood at $94 billion on Friday.

Write to Razak Musah Baba at Razak.Baba@wsj.com

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