By Josh Beckerman 

Salix Pharmaceuticals Ltd. said President and Chief Executive Carolyn Logan plans to retire by the end of January, months after an accounting issue may have derailed the drug maker's takeover.

The departure comes after the maker of the antibiotic Xifaxan had to change its accounting last year in an indication that sales of its drugs weren't as strong as Wall Street had expected. The changes prompted a board review and were accompanied by the resignation of Chief Financial Officer Adam Derbyshire.

The accounting issue also played a role in scuttling a potential takeover of the North Carolina-based company last year by Botox maker Allergan Inc., The Wall Street Journal has reported.

Chairman Tom D'Alonzo will become acting chief executive, effective Jan. 30, and Senior Vice President and General Counsel William Bertrand Jr. will be acting chief operating officer. The company will hire a search firm to look for a CEO.

Ms. Logan, who has been the company's CEO since 2002, will remain a consultant.

In November, Salix said inventory levels for its drugs were months higher than that company had earlier signaled. The higher inventory levels indicated Salix sold more to wholesalers than the wholesalers have been selling to pharmacies.

That meant demand for Salix drugs may not have been as large as its revenue in earlier quarters suggested, and the company might not be able to match the same level of sales in future quarters while wholesalers sell off their supplies.

In December, Salix unveiled plans to clear out its wholesaler inventory and withdrew its guidance, saying the plan will hurt its revenue in its current quarter and next year.

Salix's top-selling product is Xifaxan, an antibiotic that treats traveler's diarrhea and a liver disorder that impairs brain function.

In late trading, Salix shares rose 1.65% to $114.70.

Write to Josh Beckerman at josh.beckerman@wsj.com

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