By Anna Wilde Mathews and Joseph Walker 

UnitedHealth Group Inc.'s deal to acquire Catamaran Corp. for about $12.8 billion in cash will bulk up its pharmacy-benefit business amid growing concern from employers and insurers about the rising costs of cutting-edge drugs.

Catamaran, the fourth-largest pharmacy-benefit manager in the U.S. by volume of prescriptions processed, will be merged into UnitedHealth Group's OptumRx unit, the industry's third-largest and part of the company's Optum health-services arm.

UnitedHealth will pay $61.50 per share of Catamaran, a 27% premium over Friday's closing price of $48.32. The companies said they expect the deal to close in the fourth quarter.

Shares of Catamaran rose 23.8% to $59.83 through the close of regular trading on Monday. UnitedHealth shares rose 2.5% to $121.

Pharmacy-benefit managers, or PBMs, typically work for employers and health plans, managing pharmacy benefits and seeking to negotiate favorable prices with pharmaceutical companies and drugstores.

The two companies are betting that their combined size will generate increased negotiating heft and economies of scale, as they compete with Express Scripts Holding Co., the biggest PBM in the industry, and CVS Health Corp., the No. 2.

"You have to have scale," said Mark Thierer, the chief executive of Catamaran who will be CEO of the new combined company. "This makes the business more competitive overall."

Prescription-drug spending rose more than 12% last year in the U.S., the biggest annual increase in more than a decade, according to a report by Express Scripts. Specialty medicines are projected to account for half of total drug spending by 2018, compared with about 20% today, Mr. Thierer said on a February conference call.

The deal, if completed, will further consolidate an industry that has experienced a wave of mergers in recent years. The top three PBMs would represent about 75% of all pharmacy claims processed last year, according to J.P. Morgan.

In February, Rite Aid Corp. agreed to acquireEnvision Pharmaceutical Services for about $2 billion in cash and stock. Catamaran was known as SXC Health Solutions Corp. until 2012, when it completed a merger with Catalyst Health Solutions Inc.

A UnitedHealth spokesman said the combined entity would be "a competitive force in the PBM industry," which may help regulators be comfortable with the transaction.

"We would not anticipate anti-trust issues or a competitive bid from another potential acquirer," Bret Jones, an analyst with Oppenheimer & Co., said in a research note. The U.S. Federal Trade Commission cleared the merger of two much larger companies, Express Scripts and Medco Health Solutions, in a 2012 deal valued at $29.1 billion.

If completed, the new deal could carry integration risks for OptumRx. Express Scripts, based in St. Louis, struggled after its acquisition of Medco to retain some customers amid stumbles in combining the companies' back-office, technology and account-management teams.

Craig Oberg, a pharmacy-benefits consultant with the Burchfield Group in St. Paul, Minn., said he had heard from an OptumRx customer on Monday who inquired about whether the deal would have negative consequences, such as layoffs, that would affect the customer's health-plan members.

Catamaran's Mr. Thierer said OptumRx has long used software from Catamaran, and "this will lead to a seamless transition" for customers.

Shares of Express Scripts rose 3.7% through the close of regular trading Monday, a sign that investors think the company could be acquired by a large insurer or retail pharmacy chain, Brian Tanquilut, an analyst with Jefferies & Co., said in an interview. There is also a view that Express Scripts could win clients from Catamaran during its integration with OptumRx, Mr. Tanquilut said.

Catamaran had $21.58 billion in revenue last year, while OptumRx had $31.98 billion. OptumRx expanded sharply when it took over pharmacy benefits for UnitedHealth's insurance unit, UnitedHealthcare, in 2013. Both companies have been growing recently, though Catamaran in February announced the loss of two health-plan clients, putting pressure on its shares despite fourth-quarter earnings that beat analysts' expectations.

Drug spending had been relatively stable in recent years as blockbuster treatments lost patent protection and went generic. But the recent rise of new, so-called specialty medicines for diseases like hepatitis C has put increased pressure on PBMs to help employers rein in costs.

But expensive drugs also benefit PBMs, which keep a portion of the discounts they obtain from pharmaceutical companies. J.P. Morgan, in a February research note, estimated that PBMs keep as much as 15% of the negotiated rebates they obtain from pharmaceutical companies. PBMs say the vast majority of savings are passed along to customers.

Insurers and employers are bracing for the cost of expected new treatments for cancer and other conditions such as elevated cholesterol.

If the OptumRx deal with Catamaran is completed, each of the top-three PBM players would offer a different setup. Express Scripts has the largest volume in the industry. CVS has its own network of pharmacies.

The new OptumRx would pitch the benefits of analysis and data, including the broad array of health information that Optum's other businesses glean and crunch. "These capabilities can all be combined with the pharmacy side," said Larry C. Renfro, the chief executive of Optum and vice chairman of UnitedHealth Group.

The companies said they hoped to improve patients' adherence to their drug regimens, and executives pointed to deals like one recently reached by Catamaran, which tied payment for hepatitis C drugs to patients' results.

Executives from Catamaran and UnitedHealth said their customer groups should mesh well. But Catamaran currently has clients that are rivals of UnitedHealthcare. For instance, in 2013 Catamaran struck a 10-year deal to help handle pharmacy-related matters for Cigna Corp. "We expect no impact on service or operations that meet our customers' needs," a Cigna spokesman said.

Mr. Thierer said he expected Catamaran's health-plan clients would see benefits in the merger.

UnitedHealth was advised by J.P. Morgan, Bank of America, and Morgan Stanley. Catamaran was advised by Blackstone Group LP.

Write to Anna Mathews at anna.mathews@wsj.com and Joseph Walker at joseph.walker@wsj.com

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