By Saumya Vaishampayan And Chris Dieterich 

Technology and small-company stocks slid Monday, as investors turned defensive ahead of this week's decision by the Federal Reserve on interest rates.

Adding to the cautious tone was weak economic news out of China, jitters about the Scottish independence vote and the closely watched initial public offering from Alibaba Group Holding Ltd., which could be the world's largest initial public offering.

The Dow Jones Industrial Average rose 43.63 points, or 0.3%, to 17031.14, as investors favored shares of large companies such as Pfizer and Chevron. The S&P 500 index fell 1.41 points, or 0.1%, to 1984.13.

Upbeat trading in the broad market masked sharp declines in tech stocks and shares of small companies. The tech-oriented Nasdaq Composite Index dropped 48.70 points, or 1.1%, to 4518.90, its biggest one-day drop in 2 1/2 months. Investors ditched former highflying stocks including electric car maker Tesla Motor Inc., which dropped 9.1% after one Wall Street analyst cut the stock's recommendation rating.

The Russell 2000 index of small-cap stocks dropped 14.09 points, or 1.2%, to 1146.52.

Investors are paying particularly close attention to this week's Fed meeting, which ends Wednesday, amid expectations that the central bank could signal a clearer course toward raising interest rates. For stock investors, that could be good news in the longer-term should the Fed demonstrate greater confidence in the U.S. economy. But in the short-term, nervousness about the potential for higher rates has some investors thinking the market may be more vulnerable to a selloff.

"It's logical for the market to take a pause," said Bill Nichols, head of U.S. equities at Cantor Fitzgerald. "The question is by how much and when will the Fed raise rates, and what the market's reaction will be when it happens."

The S&P 500 last week suffered its first weekly decline since early August, while U.S. Treasury bonds suffered their biggest weekly selloff in a year, evidence of interest rate worries.

Ralph Segall, co-founder and chief investment officer of Chicago's Segall Bryant & Hamill, which manages $9.8 billion in stocks and bonds, said his firm has had a hard time this year finding stocks to buy at reasonable prices. A prime concern is that the market looks vulnerable to a shock as the Fed unwinds its stimulus efforts, he said.

"They've got a tiger by the tail, and I have no idea how I would let go, " Mr. Segall said, referring to Fed policy makers. "There is a large amount of complacency," he said, noting that the market has been mostly coasting higher this year without seeing major declines.

On Monday, bond buyers sent the 10-year yield down to 2.589% from 2.612% late Friday. Treasury yields rise as prices fall.

Traders said that disproportionate selling in riskier tech stocks revealed a desire to gird for potential changes to Fed policy, as well as to cash out of winning bets.

Some said that the drop in tech was due in part to large money managers raising cash to make room for Alibaba Group, which is slated to debut Friday on the New York Stock Exchange.

On the economic front, August industrial production fell 0.1% from the prior month, marking the first decline since January. Separately, data showed factory activity in the New York area jumped to its highest since late 2009, though the outlook for hiring waned, according to the New York Fed's Empire State index.

European and Asian markets reacted to data showing a slowdown in Chinese industrial production in August. Hong Kong and Australian stocks fell, and Europe, the Stoxx Europe 600 Index inched down 0.1%

Many investors are focus on a vote Thursday which will determine whether Scotland should break its more than 300-year union with England, a move that would usher in economic uncertainty.

Corporate deals also attracted attention on Monday. Microsoft Corp. agreed to buy Mojang AB, the Swedish company behind the videogame "Minecraft," for $2.5 billion. Shares of Microsoft fell 1%.

Cognizant Technology Solutions Corp. said it agreed to buy privately held TriZetto Corp., which provides information technology and other services to health-care companies, for $2.7 billion in cash. Cognizant shares slipped 1%.

Anheuser-Busch InBev NV is in talks with banks about financing a deal to buy SABMiller PLC, The Wall Street Journal reported. The deal between the world's largest brewing companies could be worth roughly GBP75 billion ($122 billion). That news comes after Heineken NV said it rejected a takeover approach from SABMiller. U.S.-listed shares of Anheuser-Busch InBev rose 3.2%.

In commodity markets, crude-oil futures added 0.7% to settle at $92.92 a barrel. Gold futures rose 0.3% to settle at $1,233.60 a troy ounce.

Write to Chris Dieterich at chris.dieterich@wsj.com and Saumya Vaishampayan at saumya.vaishampayan@wsj.com

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