ISTANBUL—Turkish police and the U.S. consulate in Istanbul have been hit in a string of deadly attacks starting early Monday, as the two North Atlantic Treaty Organization allies deepen their cooperation against Islamic State and Turkey intensifies its fight against Kurdish militants.

A police station in the city's Sultanbeyli neighborhood was struck by a suicide car-bombing at about 1 a.m. local time, injuring three policemen and seven civilians, the Istanbul Police Department said in a statement. Less than six hours later, two assailants and one police officer were killed at a gunfight that erupted when the station drew fire.

The U.S. consulate in the city's Sariyer neighborhood was attacked in shortly after the assaults on the police, with two people opening fire and prompting a clash between the attackers and police. There were no injuries or deaths, and one of the assailants has been caught, according to Turkey's state-run Anadolu news agency.

No one has claimed the attacks on the police station or the U.S. consulate, which Turkish authorities have blamed on terrorists.

In previous years, Turkey's police stations, government buildings, political parties and the courthouses have been targeted by left-wing organizations, while the U.S. consulate in Istanbul and American embassy in Ankara were hit by both leftists and Islamist militants. In 2003, al Qaeda struck the U.K. consulate in Istanbul, a synagogue and local headquarters of banking group HSBC PLC, killing dozens and injuring hundreds.

Monday's attacks come as Turkey's decision to actively wage a two-front war against Islamic State and the Kurdistan Workers' Party, or PKK, is dragging the country deeper in regional conflicts and sparking violence nationwide.

Mounting security threats at home and abroad are also fueling uncertainties, as Turkey's politicians grapple to form the country's first coalition government since 2002.

Ankara agreed in July to open up its air bases to U.S.-led coalition forces to strike Islamic State, which Turkish authorities blame for a suicide bombing by the Syrian border that killed 32 civilians. After the strike, Turkish jets joined the effort to oust Islamic State from its strongholds in Syria, launching their first strikes against the jihadist militants also known as ISIS or ISIL after a Turkish soldier was killed in a border clash.

Last week, a U.S. drone carried out its first strike on Islamic State from the Incirlik Air Base in Turkey's southern province of Adana as part of a joint effort to clamp down on a porous 70-mile stretch of the 565-mile Turkish-Syrian border that the jihadist organization controls. On Sunday, the Pentagon said it deployed six F-16 fighter jets to Incirlik and an additional 300 military personnel to step up its attacks on Islamic State.

Ankara and Washington have struck an agreement to clear the group from the region in a push to establish a safe-zone to help Western-backed Syrian rebels establish a firmer foothold in the war-torn country's north.

Meanwhile, Turkish forces also launched a sweeping campaign against the PKK, which is listed as a terrorist organization by Ankara, Washington and Brussels, and has been fighting for Kurdish autonomy in southeast Turkey since 1984. The resumption of hostilities after a two-year truce all but mark the end of peace talks to end a conflict that has killed 40,000 people.

In the past three weeks, some 70 security officials and civilians have been killed in terrorist attacks by Islamic State and the PKK. Turkey said it killed hundreds of PKK members in scores of domestic and cross-border strikes, including its headquarters and camps in the Qandil Mountains of northern Iraq. Turkish authorities have also launched a nationwide crackdown against Islamic State, the PKK, as well as some other Islamist and leftists organizations, detaining more than 1,000 people.

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