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SUMMIT THERAPEUTICS PLC (SUMM.LN), a drug discovery and development company, priced its initial public offering in the U.S. at $9.9 per American depositary share, with each ADS representing five ordinary shares.

At 1149 GMT, shares were down 8.5 pence, or 5.3%, at 152.5 pence.

BETFAIR GROUP PLC (BET.LN) gained after the betting company raised its profit guidance for fiscal 2015, as it reported third-quarter revenue growth, a performance it said was driven by double-digit growth in sports, gaming and Betfair U.S.

Shares +281 pence, or 16%, at 2,067 pence.

NORTHERN PETROLEUM PLC (NOP.LN) rose after the U.K.-listed oil and gas firm said it has entered into a joint venture agreement with oil major Royal Dutch Shell PLC (RDSB.LN) to explore Northern's onshore Cascina Alberto permit in north-west Italy.

Shares +0.6 pence, or 11%, at 6 pence.

WILLIAM SINCLAIR HOLDINGS PLC (SNCL.LN) fell after the horticultural products firm warned underlying results for fiscal 2015 would be "materially" worse than last year and said its chief executive was leaving.

Shares -11.5 pence, or 24%, at 37 pence.

AVESCO GROUP PLC (AVS.LN), a provider of services to the corporate presentation, entertainment and broadcast markets, said it expects its results for the year to Sept. 30 to be "comfortably ahead" of previous expectations.

Shares +9.5 pence, or 7.8%, at 131 pence.

EMPRESARIA GROUP PLC (EMR.LN), a staffing group, reported a rise in profit and said market conditions were favorable.

Shares +2.5 pence, or 5.2%, at 51 pence.

H&T GROUP PLC (HAT.LN) posted a 18% slide in 2014 pretax profit due to the reduced gold price. The pawnbroker said it will continue to review its product range to increase the profitability and use different asset classes as collateral for lending.

Shares +9.5 pence, or 5.9%, at 172 pence.

COMMUNISIS PLC (CMS.LN), a provider of communication services, reported a rise in full-year earnings and it is confident of posting profit growth in 2015.

Shares -2.5 pence, or 4.1%, at 58. 5 pence.

FTSE Small-Cap -0.0%

AIM +0.2%

Write to Ian Walker, Simon Zekaria, Razak Musah Baba, Alex MacDonald and Tapan Panchal at uksmallcaps@wsj.com

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