SHPG Shire Plc ADS, Each Representing Three Ordinary Shares

Total Voting Rights

September 1, 2014 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company"), in
accordance with the Financial Conduct Authority's (the "FCA") Disclosure and
Transparency Rule 5.6.1R, notifies the market of the following:

At close of business on August 31, 2014, the Company's issued ordinary share
capital comprised 589,562,539 ordinary shares of 5 pence each with voting
rights and a further 9,019,832 ordinary shares held in treasury.

Therefore the total number of voting rights in the Company is 589,562,539. This
is the figure which should be used by shareholders as the denominator for the
calculations by which they will determine if they are required to notify their
interest in, or a change to their interest in, the Company under the FCA's
Disclosure and Transparency Rules.

Tony Guthrie
Deputy Company Secretary

For further information please contact:

Investor Relations

Jeff Poulton                            jpoulton@shire.com   +1 781 482 0945

Sarah Elton-Farr                        seltonfarr@shire.com +44 1256 894157

NOTES TO EDITORS

Shire enables people with life-altering conditions to lead better lives.

Our strategy is to focus on developing and marketing innovative specialty
medicines to meet significant unmet patient needs.

We focus on providing treatments in Neuroscience, Rare Diseases,
Gastrointestinal, and Internal Medicine and we are developing treatments for
symptomatic conditions treated by specialist physicians in other targeted
therapeutic areas, such as Ophthalmology.

www.shire.com


Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX

Press Release

www.shire.com