New Affymetrix HLA Analysis Software Quickly Delivers High-Resolution HLA Types From Genotyping Data
October 06 2015 - 6:30AM
Business Wire
Affymetrix (NASDAQ: AFFX) introduces Axiom™ HLA Analysis
software for automated, high-resolution human leukocyte antigen
(HLA) typing from any genotyping dataset containing coverage of the
extended major histocompatibility complex (MHC) region. The
software’s unique imputation algorithm enables 4-digit HLA typing
from genome-wide association studies (GWAS), combining genotyping
and high-resolution HLA typing into a single assay.
HLA is the genomic region most highly associated with human
disease and is part of the MHC. The human body uses HLA proteins to
identify self versus non-self cells and to recognize cells that are
infected. The recognition of these signals triggers an immune
response. Many HLA disease associations have been reported over the
years and this remains an important area of research.
“Prior to the availability of Axiom HLA Analysis, researchers
conducted separate HLA molecular testing of their samples or used
complex analysis workflows to generate HLA types from genotype
data,” explained MaryBeth McCrumb, product manager for Affymetrix.
“The algorithms we’ve incorporated into this software provide
simple, ‘push-button’ analysis to dramatically decrease
researchers’ cost and workload.”
Human disease and transplantation researchers can benefit from
fast, economical HLA typing. This includes researchers in cancer,
immunology, inflammation, phenotype association studies, and drug
sensitivity studies. While genotyping datasets from any population
can be analyzed with the software, the current reference panel is
Caucasian-centric; additional ethnicities will be added in the
coming months.
For Affymetrix array customers, Axiom HLA Analysis software is
available free of charge and delivers HLA typing at no additional
cost. The Axiom HLA Analysis software can be used with data from a
number of Affymetrix array products, including the new Axiom®
Transplant Genotyping Array and UK Biobank Axiom® Array as well as
from Genome-Wide Human SNP Array 6.0. Genotyping data produced by
other manufacturers’ systems can be economically HLA-typed by
Affymetrix Research Service Laboratory using the new software.
About Affymetrix
Affymetrix provides leadership and support, partnering with
customers in pharmaceutical, diagnostic, and biotechnology
companies, as well as leading academic, government, and non-profit
research institutes in their quest to use biology for a better
world. More than 2,300 microarray systems have been shipped around
the world and more than 94,000 peer-reviewed papers have been
published citing Affymetrix technologies. Affymetrix is
headquartered in Santa Clara, California, and has manufacturing
facilities in Cleveland, San Diego, Vienna, and Singapore.
Affymetrix has about 1,100 employees and maintains sales and
distribution operations worldwide. For more information about
Affymetrix, please visit www.affymetrix.com
Forward-looking statements
All statements in this press release that are not historical are
"forward-looking statements" within the meaning of Section 21E of
the Securities Exchange Act as amended, including statements
regarding Affymetrix' "expectations," "beliefs," "hopes,"
"intentions," "strategies," or the like. Such statements are
subject to risks and uncertainties that could cause actual results
to differ materially for Affymetrix from those projected. These and
other risk factors are discussed in Affymetrix' Form 10-K for the
year ended December 31, 2014, and other SEC reports for subsequent
quarterly periods.
PLEASE NOTE: Axiom, Affymetrix, and
the Affymetrix logo trademarks are the property
of Affymetrix, Inc. All other trademarks are the property
of their respective owners.
View source
version on businesswire.com: http://www.businesswire.com/news/home/20151006005678/en/
Affymetrix, Inc.Media Contact:Mindy Lee-Olsen,
408-731-5523Vice President, Marketing
Servicesmindy_lee-olsen@affymetrix.comInvestor Contact:Doug
Farrell, 408-731-5285Vice President, Investor
Relationsdoug_farrell@affymetrix.com
Affymetrix (NASDAQ:AFFX)
Historical Stock Chart
From Mar 2024 to Apr 2024
Affymetrix (NASDAQ:AFFX)
Historical Stock Chart
From Apr 2023 to Apr 2024