By Scott Patterson And John W. Miller 

The world's biggest mining companies are hemorrhaging jobs as they downsize to cope with a prolonged China slowdown and a commodity-price slump that they no longer expect to end soon.

Anglo American PLC, the U.K. mining titan, on Friday announced the most dramatic jobs cut yet in the ailing industry, saying it would lop off 53,000 employees over several years--including 6,000 cuts in corporate offices that amount to $500 million in savings. That would result in a 35% reduction of its current workforce of 151,000, though much of it would come through the sale of mines, not direct layoffs.

"We're looking at every dollar and pulling everything back," Anglo-American Chief Executive Mark Cutifani said in a presentation of the miner's first-half earnings results to investors Friday. "It's a constant process driving out costs."

A broad two-year slump in commodity prices has eliminated tens of thousands of mining-related jobs across the world, from gold mines in South Africa and steelworks in the U.S. Midwest to producers of uranium in Australia and iron ore in Canada.

In the U.S. alone, mining-sector employment declined in June to its lowest level in five years, according to the Bureau of Labor Statistics. In Australia, where much of the global mining industry is based, mining employment in the June-ended quarter was down 13% from a year earlier, according to government figures.

Too much production of commodities, spurred by China's red-hot industrial growth in the past decade, has been blamed for much of the mining industry's pain since 2013. Now, miners face a "second meltdown phase" driven by ever-worsening demand as China's economy cools, said Jefferies analyst Christopher LaFemina in a note this past week.

More job cuts could be coming, with copper and gold hitting new multiyear lows on Friday after significantly weaker-than-expected manufacturing data was released in China.

"We're prepared to take steps to respond to the weaker economy" globally, Richard Adkerson, chief executive of copper miner Freeport-McMoRan, Inc., the U.S.'s biggest mining company, told analysts Thursday.

Workforce reductions figure prominently in the mining sector's push to cut costs amid the deep downturn in commodity prices driven by China's economic deceleration.

Anglo and other big miners, such as London-based BHP Billiton Ltd. and Rio Tinto PLC, are also restructuring organizations that grew quickly when the world's most populous country was gobbling up commodities. Anglo is trying to sell more than a quarter of its assets, while BHP recently spun off more than a dozen mines into a separate, public company called South32. Pittsburgh-based resources company Consol Energy Inc. said it would no longer guarantee health insurance for retired workers.

"They're all doing it across the mining world," RBC Capital Markets analyst Des Kilalea said. "They're clearing out the infrastructure."

Mining companies are being forced to shed costs after years of rampant spending on new mines and ramped-up production to feed the world's appetite for industrial metals during a boom that started in the early 2000s. By 2011, prices for the steelmaking ingredient iron ore had shot up to $190 a ton, with copper hitting a record of close to $10,000 a ton and gold exceeding $1,800 an ounce.

Miners raced to snap up mining assets, spending billions amid expectations that a "supercycle" boom would continue indefinitely. Anglo-American bet $8.8 billion on Minas-Rio, a Brazilian project it continues to develop despite crumbling iron-ore prices. BHP Billiton in 2011 shelled out $12 billion for a U.S. shale-gas company--which is now tagged for a $2 billion write-down. Rio Tinto's $6.2 billion copper and gold mine in Mongolia has encountered ballooning costs and frequent roadblocks to production.

But in 2011, just as miners were building up huge supplies, China's soaring growth began to cool, leading to a slump that continues with no end in sight, according to analysts and executives.

The markets for what the big miners sell sagged again on Friday. Three-month copper futures in London fell to $5,191.50, their lowest level in six years. Iron ore was trading for about $50 a ton.

The damage has touched nearly every mining company.

South African gold producer Lonmin PLC said Friday it would cut 6,000 workers over the next two years. So far this year, BHP has eliminated hundreds of jobs linked to Olympic Dam, its giant copper, gold and uranium mine in South Australia. Australia-based Fortescue Metals Group Ltd., the world's fourth largest iron-ore exporter, on Thursday didn't rule out further job cuts in announcing plans to cut costs in the year ahead by nearly as much as in the two past fiscal years combined. Swiss miner Glencore PLC plans to cut several hundred jobs at its South Africa coal mines.

In the U.S., the coal sector has been hit for reasons that go beyond China. It has been battered by competition from inexpensive natural gas, tougher environmental regulations and a sluggish U.S. economy. With prices off nearly a third since 2011, every significant U.S. coal company has cut jobs and a half-dozen have declared bankruptcy, prompting a crisis that has destroyed local economies throughout coal country, especially in Appalachia.

As coal output in the U.S. has dropped 15% since 2011, the number of coal miners employed in the country has shrunk to around 70,000 from over 90,000.

The moves come as oil companies and their service contractors--roiled by a similar price collapse in the crude market--have shed tens of thousands of jobs and moved to reshape their operations for what could be a long period of soft commodity prices.

None of the big diversified miners has suffered as much as Anglo, which Mr. Cutifani took over in 2013 with high hopes of turning it around. Instead, the company's profits have fallen further. On Friday, it posted a $3 billion net loss for the first half of 2015, and its share price, which has hovered at or near 13-year lows in recent weeks, fell 3.5%.

Anglo said it would need to cut $1.5 billion in costs over several years to become profitable. The job cuts are among the most drastic measures Mr. Cutifani has announced, as he looks to make the world's fifth-largest miner by market valuation more efficient. Some of that is dependent on his ability to sell some mines--something he has had trouble doing.

Rhiannon Hoyle contributed to this article.

Write to Scott Patterson at scott.patterson@wsj.com and John W. Miller at john.miller@wsj.com

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