By Josh Beckerman 

Merck & Co. has agreed to purchase biotechnology company Afferent Pharmaceuticals, whose lead drug candidate is being evaluated as a treatment for refractory, chronic cough and idiopathic pulmonary fibrosis with cough.

The deal will include an upfront payment of $500 million and milestones of up to $750 million.

San Mateo, Calif.-based Afferent focuses on targeting the P2X3 receptor for neurogenic conditions.

Last month, Afferent reported that its lead candidate, AF-219, significantly reduced cough frequency in the first cohort of a two cohort-Phase 2b study of chronic cough patients.

In July, Afferent said it completed a $55 million Series C financing led by Fidelity Management & Research Co.

Write to Josh Beckerman at josh.beckerman@wsj.com

 

(END) Dow Jones Newswires

June 09, 2016 18:14 ET (22:14 GMT)

Copyright (c) 2016 Dow Jones & Company, Inc.
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