TIDMIMM

RNS Number : 8856R

Immupharma PLC

27 September 2017

 
  FOR IMMEDIATE RELEASE    27 SEPTEMBER 2017 
 

ImmuPharma PLC

("ImmuPharma" or the "Company")

INTERIM RESULTS ANNOUNCEMENT

for the six months ended 30 June 2017

ImmuPharma PLC (LSE:IMM), ("ImmuPharma" or the "Company"), the specialist drug discovery and development company, is pleased to announce its interim results for the six months ended 30 June 2017 (the "Period").

Key Highlights

-- Lupuzor(TM) : is the Company's lead program for the potential breakthrough compound for Lupus a potential life threatening auto-immune disease

-- Total 11 sites active in US with 70 patients

-- Five European countries with 81 Lupus patients taking part in the trial: Czech Republic, France, Germany, Hungary and Poland

-- One Mauritius site with 49 Lupus patients included in trial

   --    Most recent update on progress of Lupuzor(TM) trial announced on 21 September 2017 
   --     Top line results on track to report in Q1 2018 

-- As announced on 26 September 2017, first steps initiated for Lupuzor's(TM) regulatory submissions

   --     GBP4.1 million fundraising (before expenses) successfully completed in March 2017 
   --     Northland Capital Partners appointed as sole broker and NOMAD 
   --     Stable financial performance over the Period, in line with market expectations 

o Net assets of GBP6.4 million (31 December 2016: GBP5.5 million)

o Loss for the Period of GBP3.0 million (H1 2016: GBP3.7million)

-- Research and Development expenses of GBP2.3 million (H1 2016: GBP2.5 million)

o Basic and diluted loss per share of 2.34p (H1 2016: 3.35p)

-- New employee share option plan implemented in March 2017 to continue to attract and retain key individuals

   --     'Investor' Event on 30 June 2017 

o ImmuPharma successfully hosted a technology symposium on Friday 30 June following the Company's AGM. The event attended by institutional and private investors included presentations from key management on the three core technology platforms. The video of the presentation can be seen on http://www.immupharma.co.uk/media/events

   --     New ImmuPharma website launched:  www.immupharma.co.uk 

Commenting on the Interims and outlook Tim McCarthy, Chairman, said:

"Ensuring that our pivotal Phase III Lupuzor(TM) trial progresses on track remains a key focus for ImmuPharma.

"We recently announced that all patients in the study have now passed the six months stage, with over 26% of patients having now completed the full 12 months. With a continued robust safety record, we are looking forward with confidence and planning for a successful outcome of the study with all patients completing the treatment protocol in the coming months and to reporting top-line results in Q1 2018.

"Having successfully completed a GBP4.1 million fundraising (before expenses) in March, the Board would like to thank its shareholders for their continued support, as well as its staff, corporate and scientific advisors and the CNRS for their ongoing collaboration."

This announcement contains inside information for the purposes of Article 7 of Regulation (EU) 596/2014. ("MAR")

For further information please contact:

 
                                             + 44 (0) 20 7152 
  ImmuPharma plc                                         4080 
  Tim McCarthy, Chairman 
  Dimitri Dimitriou, Chief Executive 
   Officer 
   Dr Robert Zimmer, President 
   and CSO 
  Tracy Weimar, Vice President, 
   Operations and Finance 
  Lisa Baderoon, Head of Investor 
   Relations                             + 44 (0) 7721 413496 
 
  Northland Capital Partners 
   Limited, Joint Broker                 +44 (0) 20 3861 6625 
  Patrick Claridge, David Hignell, 
   Jamie Spotswood Corporate Finance 
  Rob Rees, Corporate Broking 
 

ImmuPharma plc

Chairman's Statement

INTERIM HIGHLIGHTS

The first half of 2017 saw the continued progression of our lead program Lupuzor(TM) , for the treatment of Lupus, through significant milestones in its pivotal Phase III trial. The most recent update to the trial as announced on 21 September 2017 confirmed that as at 15 September 2017:

   --     all patients in the study have passed the 6 months stage, and 
   --     52 patients (26%) have completed the full 12 months of the study 

Importantly there continues to be a robust safety record which remains consistent with Lupuzor(TM)'s product profile as shown in its previous Phase IIb study.

As announced on 26 September 2017, with the trial progressing on track, ImmuPharma is planning ahead in anticipation of the trial's successful outcome. In consultation with our regulatory advisors, we are now progressing the completion of the regulatory dossiers in preparation for submission to the Food and Drug Administration (FDA) and the European Medicines Agency (EMA). This includes the finalisation of the Drug Master File (DMF) and in particular the manufacture of commercial batches of the Lupuzor(TM) drug. These will be manufactured according to described procedures in the DMF, to be ready for inclusion in the Company's regulatory submissions. ImmuPharma expects to have the first set of batches ready by the end of Q1 2018 in line with Lupuzor's(TM) Phase III top line results being announced.

We were also pleased to have successfully completed an oversubscribed GBP4.1 million fundraising (before expenses) in March 2017. The funds raised strengthened the Company's Statement of Financial Position and have also supported further investment in ImmuPharma's earlier stage portfolio, in particular its P140 peptide platform.

Lupuzor(TM) Phase III Trial - Progress through H1 2017

Lupuzor(TM) received approval from the US Food and Drug Administration (FDA) to start Phase III with a Special Protocol Assessment (SPA) and Fast Track designation, perceived as the 'Gold Standard' from the FDA. Under the SPA, the necessary number of patients for the Phase III programme is much lower than other Lupus development candidates in previous clinical trials and underpins the significant efficacy and safety profile shown by Lupuzor(TM) in its clinical development program to date. Importantly, this means that the total cost and time to completion of Phase III is significantly reduced.

The Phase III trial is a double-blind, randomised, placebo-controlled trial. The study involves patients being dosed for one year, receiving 0.2mg once every month subcutaneously. Significant progress was made toward completion of the trial. 293 patients were screened illustrating the demand from physicians for a new, safe and effective treatment for Lupus. Of these, the required 200 patients have been successfully recruited and randomised (dosed). Patients are participating in the trial in 7 countries across 28 sites.

In the United States the trial has been approved by a major Central Institutional Review Board (IRB) which is allowing several sites to participate through a single IRB. In Europe, the study is approved through the centralised Voluntary Harmonisation Procedure (VHP). Through the EU VHP the study is taking place in Germany, France, Czech Republic, Hungary and Poland.

ImmuPharma was also requested to open a new site in Mauritius. CAP Research, a major clinical research organisation in Mauritius, is leading the trial and 49 patients have been recruited. Mauritius, with a population of around 1.2 million, has a high proportion, approximately 300 of Lupus patients currently diagnosed. Top line data is expected during Q1 2018. Progress of the trial can be seen at: www.clinicaltrials.gov (search term 'Lupuzor').

Lupus - Opportunity

There are an estimated five million people globally suffering from Lupus, with approximately 1.5 million patients in the US, Europe and Japan (Source: Lupus Foundation of America). Current 'standard of care' treatments, including steroids and immunosuppressants, can potentially have either serious side effects for patients or limited effectiveness, with over 60% of patients not adequately treated. GSK's Benlysta is the first Lupus drug approved in many years and paves the path to market for Lupuzor(TM). Based on conservative estimates, and taking into account that Benlysta is priced currently at approximately US$30,000 per patient per year, Lupuzor(TM) would be entering a market with the potential for multi-billion dollar sales.

Lupuzor(TM) has the potential to be a novel specific first-line drug therapy for the treatment of Lupus by specifically modulating the immune system and halting disease progression in a substantial proportion of patients. Lupuzor(TM) has a unique mechanism of action that modulates the activity of CD4 T-cells which are involved in the cell-mediated immune response which leads to the Lupus disease. Lupuzor(TM), taken over the long term, as indicated in earlier stage clinical trials, has the potential to prevent the progression of Lupus rather than just treating its symptoms, with the rest of the immune system retaining the ability to work normally.

There will be a number of routes to market for Lupuzor(TM) which could include: a global licensing deal; ImmuPharma partnering with regional distributors, or an outright sale of Lupuzor(TM) or the Company. The prime objective of any strategy would be to maximise shareholder return.

Pipeline Overview

Lupuzor(TM) - Forigerimod / P140 Auto-Immune Platform

Lupuzor(TM), is also known by its chemical name 'Forigerimod' or P140.

ImmuPharma, in conjunction with the CNRS, is working hard on expanding the P140 auto immune pipeline, which is supported by Lupuzor(TM) 's strong efficacy and safety profile and by its mechanism of action.

An important patent has been granted in key countries (USA, EU, China, India and Japan) covering Lupuzor(TM) up to 2032 and its use in the treatment of a majority of autoimmune diseases such as Sjogrens, rheumatoid arthritis, Crohn's and CIDP.

Additionally, a new patent has been filed (co-owned with CNRS) to cover non-autoimmune indications. Further preclinical work continues at the CNRS with the objective of further indications moving into the clinic in due course.

Nucant Platform

Our Cancer Nucant program, IPP-204106, is focused on combination therapy approaches and ImmuPharma is reviewing a number of options to further progress this program. In 2016, a grant was awarded by the EU to different EU partners (EUR7 million total with EUR430k awarded to ImmuPharma) to develop the Nucants in combination with cytotoxic drugs linked to a solid support. The concept has been validated in pre-clinical studies. As indicated in many high-level scientific journals (Cancer Research), Nucants can be used to selectively target cancer cells and deliver on target highly cytotoxic drugs. Further, it has been proven that Nucants are drastically enhancing the effects of cytotoxic drugs at the tumour level (factor 3) allowing thereby improved efficacy and/or reduction of side effects for the same efficacy. The product, subject to funding, is ready for Phase II development.

The Group has also been awarded grants to investigate its use in age-related macular degeneration, diabetic retinopathy and other ophthalmological indications. The preliminary results are very encouraging and the product could be ready for clinical assessment provided sufficient funding is secured.

Peptide Platform

ImmuPharma's subsidiary 'Ureka' has initiated the development of a novel and innovative peptide technology platform through the Company's collaboration with CNRS, thereby gaining access to pioneering research centred on novel peptide drugs at the University of Bordeaux and the Institut Européen de Chimie et Biologie (IECB). Jointly, ImmuPharma and CNRS have filed a new co-owned patent controlling this breakthrough peptide technology. The first therapeutic area being targeted is diabetes with glucagon-like peptide -1 agonists, a class of drugs for the treatment of diabetes, as well as initiating the development of novel peptides as glucagon antagonists - one of the novel approaches to treat Type I and Type II diabetes. A consequence of this approach is the development of long acting peptides to treat NASH (Non-Alcoholic Steato-Hepatitis), one of the most important challenges for public health in the future. ImmuPharma has received non-refundable grants of approximately EUR600,000 to develop this technology with application to peptides used to treat diabetes as well as to peptides which allow the control of protein/protein interactions (cancer, targeting P53 interactions).

Investor Symposium on 30 June 2017

ImmuPharma held a technology symposium in London on 30 June 2017 following the Company's AGM. Over forty investors attended the event which included both institutions and private investors. The key objective of the event was to give further insight into ImmuPharma's three core technology platforms:

   --     Lupuzor(TM) / P140 : Auto Immune Diseases 
   --     Nucants : Oncology / Opthamology 
   --     Peptides : Metabolic Disorders 

Vadim Alexandre, Healthcare Analyst at Northland Capital Partners also provided his view on the investment case for ImmuPharma centred on Lupuzor(TM), an overview of the Auto-Immune sector and competitive landscape.

The video of the presentation can be seen on http://www.immupharma.co.uk/media/events.

Financial Review

ImmuPharma's cash balance at 30 June 2017 was GBP3.13 million (GBP1.88 million at 31 December 2016, GBP0.66 million at 30 June 2016). Further to the Lanstead sharing agreement entered into in February 2016, the Company also has GBP0.94 million as a derivative financial asset (GBP1.55 million at 31 December 2016, GBP3.14 million at 30 June 2016). The sharing agreement with Lanstead includes the provision for 18 monthly tranches of proceeds from the derivative financial asset depending on the share price performance versus an agreed benchmark price. At 30 June 2017, there were 3 monthly tranches outstanding, therefore the sharing agreement will shortly be coming to an end. The Company also has an asset in respect of a prepayment of GBP0.80 million of advanced fees to Simbec-Orion at 30 June 2017 (GBP1.24 million at 31 December 2016, GBP1.75 million at 30 June 2016). Basic and diluted loss per share were 2.34p and 2.34p respectively (30 June 2016: 3.35p and 3.35p). In line with the Company's current policy, no interim dividend is proposed.

Operating loss for the Period was GBP3.2 million (GBP3.2 million for the six months ended 30 June 2016). Research and development expenditure in the Period was GBP2.3 million (GBP2.5 million for the six months ended 30 June 2016) reflecting primarily the significantly increased expenditure related to the Lupuzor(TM) Phase III clinical trial. Administrative expenses were GBP0.93 million during the Period (GBP0.73 million for the six months ended 30 June 2016).

Given the stage of ImmuPharma's development, the fact that losses have continued to be made is to be expected since there is minimal revenue and business activity is concerned with significant investment in the form of clinical trial expenditure in addition to maintaining the infrastructure of the Group.

Current Activities and Outlook

The Board are excited by ImmuPharma's medium and long term potential. We are focused on the late stage clinical development of Lupuzor(TM) through its pivotal Phase III trial and are looking forward with confidence to announcing top-line data by the end of the first quarter of 2018. We will also continue to communicate on a regular basis with shareholders as this trial progresses.

ImmuPharma will also continue to look at ways to create further value in its assets as it progresses its other earlier stage pipeline candidates whilst exploring other opportunities around Lupuzor's(TM) mechanism of action and its applicability to other autoimmune conditions.

The Board would like to thank its shareholders, both longstanding and those who participated in the more recent fundraisings, for their support as well as its staff, corporate and scientific advisers including Simbec-Orion and the CNRS for their continued collaboration.

Tim McCarthy

Chairman

ImmuPharma plc

CONSOLIDATED INCOME STATEMENT

FOR THE PERIODED 30 JUNE 2017

 
                                Note       Unaudited         Audited      Unaudited 
                                            6 months            Year       6 months 
                                               ended           ended          ended 
                                             30 June     31 December        30 June 
                                                2017            2016           2016 
                                                 GBP             GBP            GBP 
  Continuing operations 
  Revenue                        1            86,504         164,784          2,924 
  Research and development 
   expenses                              (2,345,815)     (5,267,087)    (2,508,578) 
  Administrative expenses                  (927,640)     (1,486,858)      (733,893) 
 
 
  Operating loss                         (3,186,951)     (6,589,161)    (3,239,547) 
 
  Finance costs                                (375)        (23,085)      (501,671) 
  Finance income                             153,915         297,809            362 
 
 
  Loss before taxation                   (3,033,411)     (6,314,437)    (3,740,856) 
 
  Tax                                          (485)         990,421          (362) 
 
 
  Loss for the period                    (3,033,896)     (5,324,016)    (3,741,218) 
 
 
  Attributable to: 
  Equity holders of 
   the parent company                    (3,033,896)     (5,324,016)    (3,741,218) 
 
 
  Loss per ordinary 
   share 
 
  Basic                          2           (2.34)p         (4.54)p        (3.35)p 
 
 
 
  Diluted     2    (2.34)p    (4.54)p    (3.35)p 
 
 

ImmuPharma plc

CONSOLIDATED STATEMENT OF COMPREHENSIVE INCOME

FOR THE PERIODED 30 JUNE 2017

 
                                       Unaudited         Audited      Unaudited 
                                        6 months            Year       6 months 
                                           ended           ended          ended 
                                         30 June     31 December        30 June 
                                            2017            2016           2016 
                                             GBP             GBP            GBP 
 
  Loss for the financial 
   period                            (3,033,896)     (5,324,016)    (3,741,218) 
 
 
  Other comprehensive 
   income 
  Items that may be reclassified 
   subsequently to profit 
   or loss: 
  Exchange differences 
   on translation of foreign 
   operations                           (56,133)         317,177        224,692 
 
 
  Total items that may 
   be reclassified subsequently 
   to profit or loss                    (56,133)         317,177        224,692 
 
  Other comprehensive 
   loss for the period                  (56,133)         317,177        224,692 
 
 
  Total comprehensive 
   loss for the period               (3,090,029)     (5,006,839)    (3,516,526) 
 
 

ImmuPharma plc

CONSOLIDATED STATEMENT OF FINANCIAL POSITION

AS AT 30 JUNE 2017

 
                                  Note       Unaudited            Audited       Unaudited 
                                               30 June        31 December         30 June 
                                                  2017               2016            2016 
                                                   GBP                GBP             GBP 
  Non-current assets 
  Intangible assets                            497,585            511,088         522,668 
  Property, plant and 
   equipment                                   192,573            231,901         269,435 
  Derivative financial 
   asset                           4                 -                  -         587,054 
 
 
  Total non-current 
   assets                                      690,158            742,989       1,379,157 
 
 
  Current assets 
  Trade and other receivables                2,439,143          2,535,265       2,724,631 
  Derivative financial 
   asset                           4           943,861          1,554,866       2,556,565 
  Cash and cash equivalents                  3,131,595          1,876,718         661,009 
 
 
  Total current assets                       6,514,599          5,966,849       5,942,205 
 
 
  Current liabilities 
  Financial liabilities 
   - borrowings                                119,430            143,109         134,435 
  Trade and other payables                     473,867            786,191         767,163 
  Provisions                                    33,162             15,050               - 
 
 
  Total current liabilities                    626,459            944,350         901,598 
 
 
  Net current assets                         5,888,140          5,022,499       5,040,607 
 
 
  Non-current liabilities 
  Financial liabilities 
   - borrowings                                170,232            219,445         263,664 
 
 
  Net assets                                 6,408,066          5,546,043       6,156,100 
 
 
  EQUITY 
  Ordinary shares                           13,252,298         12,463,836      12,178,122 
  Share premium                             18,728,519         15,678,054      15,148,894 
  Merger reserve                               106,148            106,148         106,148 
  Other reserves                           (3,316,753)        (3,373,745)     (3,531,612) 
  Retained earnings                       (22,362,146)       (19,328,250)    (17,745,452) 
 
 
  Total equity                               6,408,066          5,546,043       6,156,100 
 
 

ImmuPharma plc

CONSOLIDATED STATEMENT OF CHANGES IN EQUITY

FOR THE PERIODED 30 JUNE 2017

 
                                                                  Other                  Other        Other 
                                                  Merger     reserves -               reserves     reserves        Retained 
                                                 reserve    Acquisition                      -            -        Earnings 
                                                                reserve            Translation       Equity 
                                                                                       Reserve       shares 
                      Share            Share                                                          to be                          Total 
                      capital        premium                                                         issued                         equity 
                           GBP           GBP         GBP            GBP                    GBP          GBP             GBP            GBP 
   At 1 January 
    2016             8,862,246    10,490,920     106,148    (3,541,203)            (1,926,850)    1,703,380    (14,004,234)      1,690,407 
   Loss for the 
    financial 
    period                   -             -           -              -                      -            -     (3,741,218)    (3,741,218) 
   Exchange 
    differences 
    on 
    translation 
    of foreign 
    operations               -             -           -              -                224,692            -               -        224,692 
   New issue of 
    equity 
    capital          3,315,876     5,305,401           -              -                      -            -               -      8,621,277 
   Cost of new 
    issue 
    of equity 
    capital                  -     (647,427)           -              -                      -            -               -      (647,427) 
   Share based 
    payments                 -             -           -              -                      -        8,369               -          8,369 
                  ------------  ------------  ----------  -------------  ---------------------  -----------  --------------  ------------- 
 
   At 30 June 
    2016            12,178,122    15,148,894     106,148    (3,541,203)            (1,702,158)    1,711,749    (17,745,452)      6,156,100 
                  ============  ============  ==========  =============  =====================  ===========  ==============  ============= 
 
   At 1 January 
    2016             8,862,246    10,490,920     106,148    (3,541,203)            (1,926,850)    1,703,380    (14,004,234)      1,690,407 
 
   Loss for the 
    financial 
    year                     -             -           -              -                      -            -     (5,324,016)    (5,324,016) 
   Exchange 
    differences 
    on 
    translation 
    of foreign 
    operations               -             -           -              -                317,177            -               -        317,177 
   New issue of 
    equity 
    capital          3,601,590     5,798,410           -              -                      -            -               -      9,400,000 
   Cost of new 
    issue 
    of equity 
    capital                  -     (611,276)           -              -                      -            -               -      (611,276) 
   Share based 
    payment                  -             -           -              -                      -       73,751               -         73,751 
                  ------------  ------------  ----------  -------------  ---------------------  -----------  --------------  ------------- 
 
   At 31 
    December 
    2016 & 1 
    January 
    2017            12,463,836    15,678,054     106,148    (3,541,203)            (1,609,673)    1,777,131    (19,328,250)      5,546,043 
 
   Loss for the 
    financial 
    period                   -             -           -              -                      -            -     (3,033,896)    (3,033,896) 
   Exchange 
    differences 
    on 
    translation 
    of foreign 
    operations               -             -           -              -               (56,133)            -               -       (56,133) 
   New issue of 
    equity 
    capital            788,462     3,311,542           -              -                      -            -               -      4,100,004 
   Cost of new 
    issue 
    of equity 
    capital                  -     (261,077)           -              -                      -            -               -      (261,077) 
   Share based 
    payment                  -             -           -              -                      -      113,125               -        113,125 
 
   At 30 June 
    2017            13,252,298    18,728,519     106,148    (3,541,203)            (1,665,806)    1,890,256    (22,362,146)      6,408,066 
                  ============  ============  ==========  =============  =====================  ===========  ==============  ============= 
   Attributable 
   to:- 
 
   Equity 
    holders 
    of the 
    parent 
    company         13,252,298    18,728,519     106,148    (3,541,203)            (1,665,806)    1,890,256    (22,362,146)      6,408,066 
                  ============  ============  ==========  =============  =====================  ===========  ==============  ============= 
 
 

ImmuPharma plc

CONSOLIDATED STATEMENT OF CASHFLOWS

FOR THE PERIODED 30 JUNE 2017

 
                                    Note            Unaudited               Audited            Unaudited 
                                                     6 months                  Year             6 months 
                                                        ended                                      ended 
                                                      30 June                 ended              30 June 
                                                         2017 
                                                                        31 December                 2016 
                                                                               2016           (Restated) 
                                                          GBP                   GBP                  GBP 
  Cash flows from 
   operating activities 
  Cash used in operations            3            (3,200,329)           (7,191,318)          (4,484,973) 
  Tax                                                   6,680               707,135                5,944 
  Interest paid                                         (375)               (1,917)                (496) 
 
   Net cash used in 
    operating activities                          (3,194,024)           (6,486,100)          (4,479,525) 
 
 
  Investing activities 
  Purchase of property, 
   plant and equipment                                (1,595)               (4,731)              (3,404) 
  Interest received                                       170                 1,722                  362 
 
 
  Net cash used in 
   investing activities                               (1,425)               (3,009)              (3,042) 
 
 
  Financing activities 
  (Decrease) in bank 
   overdraft                                            (138)               (1,091)              (1,199) 
  Loan repayments                                    (80,447)             (143,482)             (93,579) 
  Gross proceeds from 
   issue of new share 
   capital                                          4,100,004             9,400,000            8,621,277 
  Settlements from sharing 
   agreement                         4                682,360             2,690,451              309,650 
  Share capital issue 
   costs                                            (261,077)             (611,276)            (647,427) 
  Funds deferred per 
   sharing agreement                  4                     -           (3,949,230)          (3,949,230) 
 
 
  Net cash generated 
   from /(used in) financing 
   activities                                       4,440,702             7,385,372            4,239,492 
 
 
  Net increase/(decrease) 
   in cash and cash equivalents                     1,245,253               896,263            (243,075) 
  Cash and cash equivalents 
   at start of period                               1,876,718               833,388              833,388 
   Effects of exchange 
    rates on cash and 
    cash equivalents                                    9,624             (147,067)               70,696 
 
   Cash and cash equivalents 
    at end of period                                3,131,595             1,876,718              661,009 
 
 
 

ImmuPharma plc

NOTES TO THE CONSOLIDATED INTERIM ACCOUNTS FOR THE PERIOD ENDED 30 JUNE 2017

   1          ACCOUNTING POLICIES 

Basis of preparation

The interim financial information in this report has been prepared using accounting policies consistent with IFRS as adopted by the European Union. IFRS is subject to amendment and interpretation by the International Accounting Standards Board (IASB) and the IFRS Interpretations Committee and there is an ongoing process of review and endorsement by the European Commission. The financial information has been prepared on the basis of IFRS to be adopted by the European Union and applicable as at 31 December 2017. The Group has chosen not to adopt IAS 34 "Interim Financial Statements" in preparing the interim financial information.

The accounting policies applied are consistent with those that were applied to the financial statements for the year ending 31 December 2016.

Non-Statutory accounts

The financial information set out in this interim report does not constitute the Group's statutory accounts, within the meaning of Section 434 of the Companies Act 2006. The statutory accounts for the year ended 31 December 2016 have been filed with Registrar of Companies. The auditors reported on those accounts; their report was unqualified, did not contain a statement under either Section 498 (2) or Section 498 (3) of the Companies Act 2006 and did not include references to any matters to which the auditor drew attention by way of emphasis. The financial information for the 6 months ended 30 June 2017 and 30 June 2016 is unaudited.

Copies of this statement will be available on the Company's website - www.immupharma.com.

ImmuPharma plc

NOTES TO THE CONSOLIDATED INTERIM ACCOUNTS FOR THE PERIOD ENDED 30 JUNE 2017

(Continued)

   2              LOSS PER SHARE 
 
                                Unaudited         Audited      Unaudited 
                                 6 months            Year       6 months 
                                    ended           ended          ended 
                                  30 June     31 December        30 June 
                                     2017            2016           2016 
                                      GBP             GBP            GBP 
 
  Loss 
  Loss for the purposes 
   of basic and diluted 
   loss per share being 
   net loss attributable 
   to equity shareholders     (3,033,896)     (5,324,016)    (3,741,218) 
 
 
  Number of shares 
  Weighted average number 
   of ordinary shares for 
   the purposes of basic 
   loss per share             129,517,245     117,340,467    111,578,525 
 
 
   Basic loss per share           (2.34)p         (4.54)p        (3.35)p 
 
 
 
  Diluted loss per share          (2.34)p         (4.54)p        (3.35)p 
 
 
 

There is no difference between basic loss per share and diluted loss per share as the share options and warrants are anti-dilutive.

The group has granted share options in respect of shares to be issued.

ImmuPharma plc

NOTES TO THE CONSOLIDATED INTERIM ACCOUNTS FOR THE PERIOD ENDED 30 JUNE 2017

(Continued)

 
  3                                  CASH USED IN OPERATIONS 
                                                 Unaudited         Audited       Unaudited 
                                                  6 months            Year        6 months 
                                                     ended           ended           ended 
                                                   30 June     31 December         30 June 
                                                      2017            2016            2016 
                                                       GBP             GBP             GBP 
 
   Operating loss                              (3,186,951)     (6,589,161)     (3,239,547) 
   Depreciation & amortisation                      61,954         121,337          59,058 
   Share based payments                            113,125          73,751           8,369 
   (Increase)/decrease 
    in trade & other receivables                    34,004       (387,713)       (915,358) 
   (Decrease) in trade 
    & other payables                             (322,963)       (403,414)       (392,281) 
   Increase in provisions                           18,112          15,050               - 
   Gain/(loss) on 
    foreign exchange                                82,390        (21,168)         (5,214) 
 
    Cash used in 
     operations                                (3,200,329)     (7,191,318)     (4,484,973) 
 
 
 
 
  4    DERIVATIVE FINANCIAL ASSET 
        In February 2016, as part of a placing that 
        raised, in aggregate, GBP8.4 million (before 
        expenses) from new and existing shareholders, 
        the Company issued 17,021,277 new ordinary 
        shares to Lanstead Capital LP at a price of 
        26p per share for GBP4.4 million. All of the 
        shares were allotted to Lanstead with full 
        voting rights at that date. The Company simultaneously 
        entered into a sharing agreement with Lanstead 
        with a reference price of 34.6667p per share. 
        The sharing agreement is for an 18 month period. 
        The actual consideration is variable depending 
        upon the Company's share price. The agreement 
        is treated as a derivative financial asset 
        and valued at fair value through the income 
        statement with reference to the Company's 
        share price. 
        Of the subscription proceeds of GBP4.4 million 
        received from Lanstead, GBP3.76 million (85%) 
        was invested by the Company in the sharing 
        agreement and will be received in monthly 
        instalments over the life of the agreement. 
        The remaining GBP663,820 (15%) was available 
        for immediate working capital purposes. 
        The Company also issued, in aggregate, a further 
        851,064 new ordinary shares to Lanstead as 
        a value payment in connection with the agreement. 
        At the end of the accounting period the amount 
        receivable is restated to fair value based 
        upon the share price of the Company at that 
        date. Any change in the fair value of the 
        derivative financial asset is reflected in 
        the income statement. 
  5    SUBSEQUENT EVENTS 
 
       There were no events subsequent to 30 June 
        2017. 
 

This information is provided by RNS

The company news service from the London Stock Exchange

END

IR EASNKADAXEFF

(END) Dow Jones Newswires

September 27, 2017 02:00 ET (06:00 GMT)

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