TIDMIMM

RNS Number : 2484L

Immupharma PLC

30 September 2016

   FOR IMMEDIATE RELEASE                                              30 SEPTEMBER 2016 

ImmuPharma PLC

("ImmuPharma" or the "Company")

INTERIM RESULTS ANNOUNCEMENT

for the six months ended 30 June 2016

ImmuPharma PLC (LSE:IMM), ("ImmuPharma" or the "Company"), the specialist drug discovery and development company, is pleased to announce its interim results for the six months ended 30 June 2016 (the "Period").

Key Highlights (including post Period review)

-- Lupuzor(TM) : is the Company's lead programme for the potential breakthrough compound for Lupus a potential life threatening auto-immune disease

o Pivotal Phase III trial is progressing on track with development partner Simbec-Orion

-- Total 11 sites now active in US

-- Five European countries now recruiting Lupus patients in Czech Republic, France, Germany, Hungary and Poland

-- Two final European countries, UK and Italy, to open within the next few weeks

-- New Mauritius site opened and over 10 Lupus patients pre-screened prior to dosing

-- Prof. Sylviane Muller, inventor of Lupuzor, held a number of key symposiums hosted in London, 8-9 June 2016, where she presented on the unique 'Mechanism of Action' of Lupuzor(TM), also known by its chemical name 'Forigerimod' or 'P140'.

o Prof. Muller provided further evidence of the role the P140 molecule can take in the potential treatment of other autoimmune diseases, including those which are Orphan indications

o A new patent has been filed outside of Lupus in conjunction with the Centre National de la Recherché Scientifique ("CNRS"), its collaboration partner

   --     GBP8.4 million fundraising completed in February and March 2016 

o The Company successfully raised GBP8.4 million (gross) to fund the pivotal Phase III Lupuzor(TM) trial and to support the Company's working capital requirements

o New and existing shareholders participated in the fundraising, including all of the Directors, Simbec-Orion, Aviva, Alto Invest and Lanstead Capital

o Advance assurance received from HMRC for VCT and EIS qualifying status

   --     Wider program developments 

o A number of options are under review to further progress ImmuPharma's Cancer Nucant program, IPP-204106 following a Phase I/IIa dose-finding adaptive study which showed that the maximum tolerated dose was 9 mg/kg, the primary objective of the study

o ImmuPharma and CNRS have filed a new co-owned patent controlling the Company's peptide platform technology, with Type II diabetes being the first therapeutic area to be targeted.

o An additional patent has been filed by ImmuPharma to protect certain peptides (GLP1 analogues) demonstrating outstanding properties in terms of duration of action.

   --     Northland Capital Partners appointed as joint broker 
   --     Stable financial performance over the Period, in line with market expectations 

o Net assets of GBP6.2 million (31 December 2015 GBP1.7 million).

o Loss for the period of GBP3.7m (H1 2015: GBP1.5m)

-- Research and Development expenses of GBP2.5 million (H1 2015: GBP0.9 million)

o Basic and diluted loss per share of 3.35p (H1 2015: 1.74p)

Commenting on the Interims and outlook Tim McCarthy, Chairman, said:

"Successfully raising GBP8.4 million and commencing our pivotal Phase III Lupuzor(TM) trial are two significant milestones for ImmuPharma over the first half of 2016.

"We are delighted by the continued progress of our Lupuzor(TM) Phase III trial having recently announced that the US now has 11 sites active and five countries across Europe are currently recruiting Lupus patients with two further countries including the UK to open in the near future. The opening of a new additional site in Mauritius clearly illustrates the positive profile Lupuzor(TM) is gaining within key cross sections of Lupus patient groups and within the specialist rheumatologist community.

"We remain confident of reaching our key milestone of recruiting the full 200 patients in 2016 with top line results in 2017 and look forward to providing further positive updates on this Lupuzor(TM) Phase III study as it progresses throughout the end of this year and 2017.

"The Board would like to thank its shareholders for their support, as well as its staff, corporate and scientific advisors and the CNRS for their continued collaboration."

This announcement contains inside information for the purposes of Article 7 of Regulation (EU) 596/2014. ("MAR")

For further information please contact:

 
                                            + 44 (0) 20 7152 
  ImmuPharma plc                                        4080 
  Tim McCarthy, Chairman 
  Dimitri Dimitriou, Chief 
   Executive Officer 
  Tracy Weimar, Vice President, 
   Operations and Finance 
  Lisa Baderoon, Head of Investor 
   Relations                            + 44 (0) 7721 413496 
 
  Panmure, Gordon & Co., NOMAD 
   & Broker                             +44 (0) 20 7886 2500 
  Freddy Crossley, Duncan Monteith, 
   Corporate Finance 
  Charles Leigh-Pemberton, 
   Corporate Broking 
 
  Northland Capital Partners 
   Limited, Joint Broker                +44 (0) 20 3861 6625 
  Patrick Claridge, David Hignell, 
   Corporate Finance 
  Rob Rees, Corporate Broking 
 

CHAIRMAN'S STATEMENT

The first half of 2016 was dedicated to the progress of our lead programme, Lupuzor(TM) (a breakthrough treatment for the auto-immune disease Lupus), as it commenced its pivotal Phase III trial and the dosing of Lupus patients in the US and across Europe. This was combined with the strengthening of our financial position by completing a successful placing and subscription raising GBP8.4 million before expenses in February and March.

To focus initially on the fundraising it was a sign of widespread support that as part of the completion of the GBP8.4 million funding round key participators included:

   --    All of the Directors 
   --    Simbec-Orion, our development partner 
   --    Aviva, our longstanding major institutional investor 
   --    New institutions including Alto Invest, a specialist Healthcare fund, and Lanstead Capital 
   --    Longstanding private client shareholders 

As part of the fundraising exercise, ImmuPharma also received confirmation of advance assurance from HM Revenue and Customs that it is a qualifying holding for the purposes of the Venture Capital Trust rules and a qualifying company for the purposes of the Enterprise Investment Scheme. These assurances were important for attracting a significant proportion of new shareholders into the recent fundraising.

Lupuzor(TM) Phase III Trial - Progress through H1 2016

As background to the study, we stated that recruitment would occur in up to 45 investigator sites, 10 sites in United States and 35 in Europe, to ensure the screening of 270 potential patients, in order to recruit the required 200 patients for the trial. The Phase III trial is a double-blind, randomised, placebo-controlled trial. The study will involve patients dosing for one year, receiving 0.2mg once every month subcutaneously.

Current Status

We can now confirm that we have 11 sites opened in the US. In Europe we have sites open in five countries - France, Hungary, Poland, Czech Republic and Germany. A further two countries, UK and Italy, will open in the next few weeks. Further details on the trial and updates on recruitment can be seen at: www.ClinicalTrials.gov.

New Site in Mauritius: post review period

On 7 September we announced the opening of a new site in Mauritius. This was a new country allocation due to the request from the Mauritian Government based on the high incidence of Lupus sufferers, approximately 3000, in this region. We have indicated that around 30 Lupus patients will be included in the current Lupuzor Phase III trial.

Lupuzor(TM) Symposium

In June, ImmuPharma organised a number of presentations attended by investors, sell side analysts and media, hosted by Prof. Muller, the inventor of Lupuzor(TM) in which she presented on the unique 'Mechanism of Action' of Lupuzor(TM), also known by its chemical name 'Forigerimod' or 'P140' and provided further evidence of the role the P140 molecule can take in the potential treatment of other autoimmune diseases. A video of the presentation is available to view on the Company's website on: http://www.immupharma.org/events/2016.

There are an estimated five million people globally suffering from Lupus, with approximately 1.5 million patients in the US, Europe and Japan (Source: Lupus Foundation of America). Current 'standard of care' treatments, including steroids and immunosuppressants, can potentially have either serious side effects for patients or limited effectiveness, with over 60% of patients not adequately treated. GSK's Benlysta is the first Lupus drug approved in many years and paves the path to market for Lupuzor(TM). Based on conservative estimates, and taking into account that Benlysta is priced currently at approximately $35,000 per patient per year, Lupuzor(TM) would be entering a market with the potential for multi-billion dollar sales.

Lupuzor(TM) has the potential to be a novel specific first-line drug therapy for the treatment of Lupus by specifically modulating the immune system and halting disease progression in a substantial proportion of patients. Lupuzor(TM) has a unique mechanism of action that modulates the activity of CD4 T-cells which are involved in the cell-mediated immune response which leads to the Lupus disease. Lupuzor(TM), taken over the long term, as indicated in earlier stage clinical trials, has the potential to prevent the progression of Lupus rather than just treating its symptoms, with the rest of the immune system retaining the ability to work normally.

There will be a number of routes to market for Lupuzor(TM) which could be: a global licensing deal; ImmuPharma partnering with regional distributors, or an outright sale of Lupuzor(TM) or the Company. The prime objective of any strategy would be to maximise shareholder return.

Pipeline Overview

Forigerimod / P140 Auto-Immune Platform

Lupuzor(TM), is also known by its chemical name 'Forigerimod' or P140.

ImmuPharma, in conjunction with the CNRS, is working hard on expanding the P140 auto immune pipeline, which is supported by Lupuzor(TM) 's strong efficacy and safety profile and by its mechanism of action.

A new patent has been filed (co-owned with CNRS) to cover other autoimmune indications, outside of Lupus, some of which have the potential for Orphan Drug designation. Further preclinical work continues with the objective of further indications moving into the clinic in due course.

Nucant Platform

The Company's Cancer Nucant program, IPP-204106, is focused on combination therapy approaches. The Phase I/IIa dose-finding adaptive study where the Nucant was associated with chondroitin sulphate demonstrated that the maximum tolerated dose was 9 mg/kg, which was the primary objective of the study. ImmuPharma is now reviewing a number of options to further progress this program. A grant was awarded by the EU to develop the Nucants in combination with cytotoxic drugs linked to a solid support. The concept has been validated in pre-clinical studies.

The Group has also been awarded grants to investigate its use in age-related macular degeneration, diabetic retinopathy and other ophthalmological indications.

Peptide Platform

ImmuPharma's subsidiary 'Ureka' has initiated the development of a novel and innovative peptide technology platform through the Company's collaboration with CNRS, thereby gaining access to pioneering research centred on novel peptide drugs at the University of Bordeaux and the Institut Européen de Chimie et Biologie (IECB). Jointly, ImmuPharma and CNRS have filed a new co-owned patent controlling this breakthrough peptide technology. The first therapeutic area being targeted is diabetes with glucagon-like peptide -1 agonists, a class of drugs for the treatment of diabetes, as well as initiating the development of novel peptides as glucagon antagonists - one of the novel approaches to treat Type I and Type II diabetes. ImmuPharma has received non-refundable grants of approximately EUR600,000 to develop this technology with application to peptides used to treat diabetes as well as to peptides which allow the control of protein/protein interactions (cancer).

Financial Review

ImmuPharma's cash balance at 30 June 2016 was GBP0.66 million (GBP0.83 million at 31 December 2015, GBP3.3 million at 30 June 2015). Further to the Lanstead sharing agreement entered into in February, the Company also has GBP3.1 million as a derivative financial asset. The sharing agreement with Lanstead includes the provision for 18 monthly tranches of proceeds from the derivative financial asset depending on the share price performance versus an agreed benchmark price, with 15 tranches outstanding at the 30 June 2016. The Company also has an asset in respect of a prepayment of GBP1.75 million of advanced fees to Simbec-Orion at 30 June 2016. Basic and diluted loss per share were 3.35p and 3.35p respectively (30 June 2015: 1.74p and 1.74p). In line with the Company's current policy, no interim dividend is proposed.

Operating loss for the period was GBP3.2 million (GBP1.5 million for the six months ended 30 June 2015). Research and development expenditure in the period was GBP2.5 million (GBP0.87 million for the six months ended 30 June 2015) reflecting primarily the significantly increased expenditure related to the Lupuzor(TM) Phase III clinical trial. Administrative expenses were GBP733,893 during the Period (GBP677,111 for the six months ended 30 June 2015). Consistent with the reclassification of expenses between research and development and administration undertaken for the accounts for the year ended 31 December 2015, the expenses for the 6 months ended 30 June 2015 have also been reclassified to aid comparability.

Given the stage of ImmuPharma's development, the fact that losses have continued to be made is to be expected since there is minimal revenue and business activity is concerned with significant investment in the form of clinical trial expenditure in addition to maintaining the infrastructure of the Group.

Current Activities and Outlook

The Board continues to be excited by ImmuPharma's potential. We are focused on the late stage clinical development of Lupuzor(TM) through its pivotal Phase III trial through to its results, which we are confident of announcing in respect of the top-line data by the end of 2017, and to communicate on a regular basis with shareholders as this trial progresses. We are now also beginning to have dialogue with a number of Lupus patient groups, both in the UK and the USA, and we will increase our efforts within this important and powerful community throughout this year and beyond.

ImmuPharma will also progress its other earlier stage pipeline candidates whilst exploring other opportunities around Lupuzor(TM) 's mechanism of action and its applicability to other autoimmune conditions.

The Board would like to thank its shareholders, both longstanding and those who participated in the recent fundraising, for their support as well as its staff, corporate and scientific advisers including Simbec-Orion and the CNRS for their continued collaboration.

Tim McCarthy

Chairman

29 September 2016

Independent Review Report to ImmuPharma plc

Introduction

We have been engaged by ImmuPharma plc ("the Company") to review the condensed set of consolidated financial statements in the interim report for the six months ended 30 June 2016 which comprises the Consolidated Income Statement, the Consolidated Statement of Comprehensive Income, the Consolidated Statement of Financial Position, the Consolidated Statement of Changes in Equity, the Consolidated Statement of Cashflows, and the related notes 1 to 5.

We have read the other information contained in the interim report and considered whether it contains any apparent misstatements or material inconsistencies with the financial information in the condensed set of financial statements.

This report is made solely to the Company in accordance with the terms of our engagement to assist the Company in meeting the requirements of AIM Rule 18. Our review has been undertaken so that we might state to the Company those matters we are required to state to it in this report and for no other purpose. To the fullest extent permitted by law, we do not accept or assume responsibility to anyone other than the Company for our review work, for this report or for the conclusions we have reached.

Directors' responsibilities

The interim report is the responsibility of, and has been approved by, the directors. The directors are responsible for preparing the interim report in accordance with AIM Rule 18.

As disclosed in note 1, the annual financial statements of the Group are prepared in accordance with IFRS as adopted by the European Union. It is the responsibility of the directors to ensure that the condensed set of financial statements included in this interim report have been prepared on a basis consistent with that which will be adopted in the Group's annual financial statements.

Our responsibility

Our responsibility is to express to the Company a conclusion on the condensed set of financial statements in the interim report based on our review.

Scope of review

We conducted our review in accordance with International Standard on Review Engagements (UK and Ireland) 2410 "Review of Interim Financial Information Performed by the Independent Auditor of the Entity" issued by the Auditing Practices Board for use in the United Kingdom. A review of interim financial information consists of making enquiries, primarily of persons responsible for financial and accounting matters, and applying analytical and other review procedures.

A review is substantially less in scope than an audit conducted in accordance with International Standards on Auditing (UK and Ireland) and consequently does not enable us to obtain assurance that we would become aware of all significant matters that might be identified in an audit. Accordingly we do not express an audit opinion.

Conclusion

Based on our review, nothing has come to our attention that causes us to believe that the condensed set of financial statements in the interim report for the six months ended 30 June 2016 is not prepared, in all material respects, in accordance with the requirements of the AIM rules.

25 Moorgate

London

Nexia Smith & Williamson EC2R 6AY

Statutory Auditor

Chartered Accountants 29 September 2016

ImmuPharma plc

CONSOLIDATED INCOME STATEMENT

FOR THE PERIODED 30 JUNE 2016

 
                                Note      Unaudited         Audited      Unaudited 
                                           6 months            Year       6 months 
                                              ended           ended          ended 
                                            30 June     31 December        30 June 
                                               2016            2015           2015 
                                                GBP             GBP            GBP 
  Continuing operations 
  Revenue                                     2,924          76,407         13,559 
  Research and development 
   expenses                             (2,508,578)     (2,993,717)      (873,722) 
  Administrative expenses                 (733,893)     (1,645,799)      (677,111) 
 
 
  Operating loss                        (3,239,547)     (4,563,109)    (1,537,274) 
 
  Finance costs                           (501,671)         (1,208)        (7,172) 
  Finance income                                362          15,843          3,179 
 
 
  Loss before taxation                  (3,740,856)     (4,548,474)    (1,541,267) 
 
  Tax                                         (362)         650,977              - 
 
 
  Loss for the period                   (3,741,218)     (3,897,497)    (1,541,267) 
 
 
  Attributable to: 
  Equity holders of 
   the parent company                   (3,741,218)     (3,897,497)    (1,541,267) 
 
 
  Loss per ordinary 
   share 
 
  Basic                          2          (3.35)p         (4.40)p        (1.74)p 
 
 
 
  Diluted     2    (3.35)p    (4.40)p    (1.74)p 
 
 

ImmuPharma plc

CONSOLIDATED STATEMENT OF COMPREHENSIVE INCOME

FOR THE PERIODED 30 JUNE 2016

 
                                       Unaudited         Audited      Unaudited 
                                        6 months            Year       6 months 
                                           ended           ended          ended 
                                         30 June     31 December        30 June 
                                            2016            2015           2015 
                                             GBP             GBP            GBP 
 
  Loss for the financial 
   period                            (3,741,218)     (3,897,497)    (1,541,267) 
 
 
  Other comprehensive 
   income 
  Items that may be reclassified 
   subsequently to profit 
   or loss: 
  Exchange differences 
   on translation of foreign 
   operations                            224,692       (117,478)      (180,262) 
 
 
  Total items that may 
   be reclassified subsequently 
   to profit or loss                     224,692       (117,478)      (180,262) 
 
  Other comprehensive 
   loss for the period                   224,692       (117,478)      (180,262) 
 
 
  Total comprehensive 
   loss for the period               (3,516,526)     (4,014,975)    (1,721,529) 
 
 

ImmuPharma plc

CONSOLIDATED STATEMENT OF FINANCIAL POSITION

AS AT 30 JUNE 2016

 
                                  Note       Unaudited            Audited       Unaudited 
                                               30 June        31 December         30 June 
                                                  2016               2015            2015 
                                                   GBP                GBP             GBP 
  Non-current assets 
  Intangible assets                            522,668            522,462         530,354 
  Property, plant and 
   equipment                                   269,435            280,127         304,590 
  Derivative financial 
   asset                           4           587,054                  -               - 
 
 
  Total non-current 
   assets                                    1,379,157            802,589         834,944 
 
 
  Current assets 
  Trade and other receivables                2,724,631          1,577,091         720,547 
  Derivative financial 
   asset                           4         2,556,565                  -               - 
  Cash and cash equivalents                    661,009            833,388       3,294,819 
 
 
  Total current assets                       5,942,205          2,410,479       4,015,366 
 
 
  Current liabilities 
  Financial liabilities 
   - borrowings                                134,435            163,070         295,634 
  Trade and other payables                     767,163          1,078,640         243,464 
  Provisions                                         -                  -           9,663 
 
 
  Total current liabilities                    901,598          1,241,710         548,761 
 
 
  Net current assets                         5,040,607          1,168,769       3,466,605 
 
 
  Non-current liabilities 
  Financial liabilities 
   - borrowings                                263,664            280,951         317,696 
 
 
  Net assets                                 6,156,100          1,690,407       3,983,853 
 
 
  EQUITY 
  Ordinary shares                           12,178,122          8,862,246       8,862,246 
  Share premium                             15,148,894         10,490,920      10,490,920 
  Merger reserve                               106,148            106,148         106,148 
  Other reserves                           (3,531,612)        (3,764,673)     (3,827,457) 
  Retained earnings                       (17,745,452)       (14,004,234)    (11,648,004) 
 
 
  Total equity                               6,156,100          1,690,407       3,983,853 
 
 

ImmuPharma plc

CONSOLIDATED STATEMENT OF CHANGES IN EQUITY

FOR THE PERIODED 30 JUNE 2016

 
                                                                  Other                  Other        Other 
                                                  Merger     reserves -               reserves     reserves        Retained 
                                                 reserve    Acquisition                      -            -        Earnings 
                                                                reserve            Translation       Equity 
                                                                                       Reserve       shares 
                      Share            Share                                                          to be                          Total 
                     capital         premium                                                         issued                         equity 
                           GBP           GBP         GBP            GBP                    GBP          GBP             GBP            GBP 
   At 1 January 
    2015             8,862,246    10,490,920     106,148    (3,541,203)            (1,809,372)    1,703,380    (10,106,737)      5,705,382 
 
   Loss for the 
    financial 
    period                   -             -           -              -                      -            -     (1,541,267)    (1,541,267) 
   Exchange 
    differences 
    on 
    translation 
    of foreign 
    operations               -             -           -              -              (180,262)            -               -      (180,262) 
 
 
   At 30 June 
    2015             8,862,246    10,490,920     106,148    (3,541,203)            (1,989,634)    1,703,380    (11,648,004)      3,983,853 
 
 
   At 1 January 
    2015             8,862,246    10,490,920     106,148    (3,541,203)            (1,809,372)    1,703,380    (10,106,737)      5,705,382 
 
   Loss for the 
    financial 
    year                     -             -           -              -                      -            -     (3,897,497)    (3,897,497) 
   Exchange 
    differences 
    on 
    translation 
    of foreign 
    operations               -             -           -              -              (117,478)            -               -      (117,478) 
 
 
   At 31 
    December 
    2015 & 1 
    January 
    2016             8,862,246    10,490,920     106,148    (3,541,203)            (1,926,850)    1,703,380    (14,004,234)      1,690,407 
 
   Loss for the 
    financial 
    period                   -             -           -              -                      -            -     (3,741,218)    (3,741,218) 
   Exchange 
    differences 
    on 
    translation 
    of foreign 
    operations               -             -           -              -                224,692            -               -        224,692 
   New issue of 
    equity 
    capital          3,315,876     5,305,401           -              -                      -            -               -      8,621,277 
 
   Costs of new 
    issue 
    of equity 
    capital                  -     (647,427)           -              -                      -            -               -      (647,427) 
 
   Share based 
    payments                 -             -           -              -                      -        8,369               -          8,369 
 
 
   At 30 June 
    2016            12,178,122    15,148,894     106,148    (3,541,203)            (1,702,158)    1,711,749    (17,745,452)      6,156,100 
 
   Attributable 
   to:- 
 
   Equity 
    holders 
    of the 
    parent 
    company         12,178,122    15,148,894     106,148    (3,541,203)            (1,702,158)    1,711,749    (17,745,452)      6,156,100 
 
 
 

ImmuPharma plc

CONSOLIDATED STATEMENT OF CASHFLOWS

FOR THE PERIOD ENDED 30 JUNE 2016

 
                                 Note      Unaudited         Audited      Unaudited 
                                            6 months            Year       6 months 
                                               ended           ended          ended 
                                             30 June     31 December        30 June 
                                                2016            2015           2015 
                                                 GBP             GBP            GBP 
  Cash flows from 
   operating activities 
  Cash used in operations         3      (4,484,973)     (4,582,411)    (2,329,728) 
  Tax                                          5,944         435,261        521,147 
  Interest paid                                (496)         (1,208)          (189) 
 
   Net cash used in 
    operating activities                 (4,479,525)     (4,148,358)    (1,808,770) 
 
 
  Investing activities 
  Purchase of property, 
   plant and equipment                       (3,404)        (20,761)       (12,838) 
  Interest received                              362          11,541          3,179 
 
 
  Net cash used in 
   investing activities                      (3,042)         (9,220)        (9,659) 
 
 
  Financing activities 
  (Decrease)/increase 
   in bank overdraft                         (1,199)             879          (327) 
  Loan received                                    -          22,130         21,180 
  Loan repayments                           (93,579)       (333,135)      (273,016) 
  Net proceeds from issue                  4,024,620                              - 
   of new equity capital                                           - 
  Derivative repayments                      309,650                              - 
   received                                                        - 
 
 
  Net cash generated 
   from /(used in) financing 
   activities                              4,239,492       (310,126)      (252,163) 
 
 
  Net decrease in cash 
   and cash equivalents                    (243,075)     (4,467,704)    (2,070,592) 
  Cash and cash equivalents 
   at start of period                        833,388       5,424,033      5,424,033 
   Effects of exchange 
    rates on cash and 
    cash equivalents                          70,696       (122,941)       (58,622) 
 
   Cash and cash equivalents 
    at end of period                         661,009         833,388      3,294,819 
 
 
 

ImmuPharma plc

NOTES TO THE INTERIM ACCOUNTS FOR THE PERIOD ENDED 30 JUNE 2016

   1          ACCOUNTING POLICIES 

Basis of preparation

The interim financial information in this report has been prepared using accounting policies consistent with IFRS as adopted by the European Union. IFRS is subject to amendment and interpretation by the International Accounting Standards Board (IASB) and the IFRS Interpretations Committee and there is an ongoing process of review and endorsement by the European Commission. The financial information has been prepared on the basis of IFRS that the Directors expect to be adopted by the European Union and applicable as at 31 December 2016. The Group has chosen not to adopt IAS 34 "Interim Financial Statements" in preparing the interim financial information.

The accounting policies applied are consistent with those that were applied to the financial statements for the year ending 31 December 2015 with the addition of the following accounting policy which has been adopted in respect of the derivative financial asset:-

Valuation of Derivative Financial Asset

The Company has placed shares with Lanstead Capital LP and at the same time entered into a sharing agreement. The amount receivable each month, over an 18 month period will be dependent on the Company's share price performance. At each period end the amount receivable is restated to fair value. Any change in the fair value of the derivative financial asset is reflected in the income statement within finance costs.

Research and Development

Research and development expenses consist of costs directly attributable to pharmaceutical research and development activities, including administrative costs directly attributable to these activities. During the year ended 31 December 2015, the Group reviewed the classification of certain items of expenditure to ensure that they had been classified in accordance with this policy. The 6 months ended 30 June 2015 expenditure analysis has been restated in order to present it on a consistent basis with that applied in the year ended 31 December 2015.

Non-Statutory accounts

The financial information set out in this interim report does not constitute the Group's statutory accounts. The statutory accounts for the year ended 31 December 2015 have been delivered to the Registrar of Companies. The auditors reported on those accounts; their report was unqualified, did not contain a statement under either Section 498 (2) or Section 498 (3) of the Companies Act 2006 and did not include references to any matters to which the auditor drew attention by way of emphasis. The financial information for the 6 months ended 30 June 2016 and 30 June 2015 is unaudited.

Copies of this statement will be available on the Company's website - www.immupharma.com.

ImmuPharma plc

NOTES TO THE INTERIM ACCOUNTS FOR THE PERIOD ENDED 30 JUNE 2016

(continued)

   2              LOSS PER SHARE 
 
                                Unaudited         Audited      Unaudited 
                                 6 months            Year       6 months 
                                    ended           ended          ended 
                                  30 June     31 December        30 June 
                                     2016            2015           2015 
                                      GBP             GBP            GBP 
 
  Loss 
  Loss for the purposes 
   of basic and diluted 
   loss per share being 
   net loss attributable 
   to equity shareholders     (3,741,218)     (3,897,497)    (1,541,267) 
 
 
  Number of shares 
  Weighted average number 
   of ordinary shares for 
   the purposes of basic 
   loss per share             111,578,525      88,622,463     88,622,463 
 
 
   Basic loss per share           (3.35)p         (4.40)p        (1.74)p 
 
 
 
  Diluted loss per share          (3.35)p         (4.40)p        (1.74)p 
 
 
 

There is no difference between basic loss per share and diluted loss per share as the share options and warrants are anti-dilutive.

ImmuPharma plc

NOTES TO THE INTERIM ACCOUNTS FOR THE PERIOD ENDED 30 JUNE 2016

(continued)

 
  3                                CASH USED IN OPERATIONS 
                                               Unaudited         Audited       Unaudited 
                                                6 months            Year        6 months 
                                                   ended           ended           ended 
                                                 30 June     31 December         30 June 
                                                    2016            2015            2015 
                                                     GBP             GBP             GBP 
 
   Operating loss                            (3,239,547)     (4,563,109)     (1,537,274) 
   Depreciation & amortisation                    59,058         121,748          62,521 
   Share based payments                            8,369               -               - 
   Increase in trade & 
    other receivables                          (915,358)       (674,440)       (484,482) 
   (Decrease)/increase 
    in trade & other payables                  (392,281)         552,556       (349,705) 
   Decrease in provisions                              -        (23,468)        (13,805) 
   (Gain)/loss on 
    foreign exchange                             (5,214)           4,302         (6,983) 
 
    Cash used in 
     operations                              (4,484,973)     (4,582,411)     (2,329,728) 
 
 
 
 
  4    DERIVATIVE FINANCIAL ASSET 
        In February 2016, as part of a placing that 
        raised, in aggregate, GBP8.4 million (before 
        expenses) from new and existing shareholders, 
        the Company issued 17,021,277 new ordinary 
        shares to Lanstead Capital LP at a price of 
        26p per share for GBP4.4 million. All of the 
        shares were allotted to Lanstead with full 
        voting rights at that date. The Company simultaneously 
        entered into a sharing agreement with Lanstead 
        with a reference price of 34.6667p per share. 
        The sharing agreement is for an 18 month period. 
        The actual consideration is variable depending 
        upon the Company's share price. The agreement 
        is treated as a derivative financial asset 
        and valued at fair value through the income 
        statement with reference to the Company's 
        share price. 
        Of the subscription proceeds of GBP4.4 million 
        received from Lanstead, GBP3.76 million (85%) 
        was invested by the Company in the sharing 
        agreement and will be received in monthly 
        instalments over the life of the agreement. 
        The remaining GBP663,820 (15%) was available 
        for immediate working capital purposes. 
        The Company also issued, in aggregate, a further 
        851,064 new ordinary shares to Lanstead as 
        a value payment in connection with the agreement. 
        At the end of the accounting period the amount 
        receivable is restated to fair value based 
        upon the share price of the Company at that 
        date. Any change in the fair value of the 
        derivative financial asset is reflected in 
        the income statement. 
  5    SUBSEQUENT EVENTS 
 
       There were no events subsequent to 30 June 
        2016. 
 

This information is provided by RNS

The company news service from the London Stock Exchange

END

IR LLMATMBMTBLF

(END) Dow Jones Newswires

September 30, 2016 02:00 ET (06:00 GMT)

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