Eli Lilly & Co. (LLY) logged better-than-expected profit and revenue in the latest quarter, boosted by higher U.S. prices and its acquisition of Novartis AG's (NVS, NOVN.VX) animal health unit.

The upbeat results came despite the lingering effect of patent expirations and foreign-exchange pressures.

Lilly, like other pharmaceutical companies, is working to counter a wave of patent expirations, and resulting sales pressures, by broadening its research and business models.

In March, Lilly agreed to form one of the broadest collaborations to date between a large Western drug maker and a Chinese biotechnology company, paying $56 million to startup Innovent Biologics Inc. to co-develop at least three experimental cancer drugs.

Lilly is looking to boost its business by relying on treatments for diabetes and cancer patients, as well as medical products for animals.

It has also reached pacts with Merck Co. (MRK) and Bristol-Myers Squibb Co. (BMY) to collaborate on trials for immunotherapy drugs.

In the latest quarter, animal health sales grew 42% to $749.8 million.

Meanwhile, sales of Cymbalta fell 40% to $287 million, and Evista sales plunged 55% to $66.8 million due to patent expirations.

Overall, Lilly posted earnings of $529.5 million, or 50 cents a share, down from $727.9 million, or 68 cents a share, in the prior-year period.

Excluding items such as restructuring and asset-impairment charges, earnings were 87 cents a share, up from 74 cents a year earlier.

Revenue edged down 1% to $4.64 billion.

Analysts had projected a per-share profit of 77 cents and revenue of $4.62 billion.

For the year, the company lowered its earnings forecast to $2.21 to $2.31 a share from $2.40 to $2.50 a share. Lilly reaffirmed its profit forecast, excluding special items.

Write to Chelsey Dulaney at chelsey.dulaney@wsj.com

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