By Carla Mozee, MarketWatch

LONDON (MarketWatch) -- European stocks declined Tuesday, with investors facing uncertainty from the U.S. Federal Reserve's outlook on interest rates and the implications for European markets. Adding to the mix of unknowns was what lies ahead for the U.K. after Scotland votes on the issue of independence on Thursday.

Data: Concerns about weakening conditions in the German economy -- the largest in Europe -- were underscored Tuesday after the closely watched ZEW indicator of economic expectations posted a larger-than-expected fall. The survey's indicator for current conditions dropped to 25.4 in September from 44.3 in August. The September reading missed expectations of 41.0 from a Wall Street Journal poll of analysts.

Markets: European stocks overall held to losses after the ZEW survey was released, with the Stoxx Europe 600 ending down 0.3% at 342.84. Germany's DAX 30 closed down 0.3% at 9,632.93.

The Fed is on the radar for global investors as the U.S. central bank begins its two-day meeting, with policy makers expected to lay the groundwork for eventually raising interest rates. Read: Eight keys to the Fed's September meeting.

"It's very difficult for people to argue that the Fed's ultra-loose monetary policy stance has not been largely responsible for stocks rallying to their highest-ever levels," said Craig Erlam, market analyst at Alpari, wrote Tuesday. "Now that this is coming to an end, with asset purchases falling to zero next month and the first interest-rate hike around the corner, people are getting nervous." U.S. stock futures were lower on Tuesday.

Meanwhile, the Scottish independence referendum will be held Thursday, with various polls indicating the vote on whether to break away from the U.K. is too close to call. "If the Scots do vote to exit, much may depend on how quickly they accept having a freely floating exchange rate as the way forwards," said David Owen, chief European financial economist at Jefferies. "Our central case remains that Scotland will still vote to remain in the Union (just), but analysis of the subject suggests that very little for exit is priced into short sterling."

Stocks: Among individual movers, Orange SA shares fell 1.4% after the French telecommunications company bid EUR3.33 billion ($4.31 billion) for Spanish broadband and cellphone operator Jazztel SA. But shares of Jazztel popped up 6.3%, the best performers on the Stoxx 600.

"[We] see limited likelihood of a counter offer for Jazztel from any other player," said telecoms analysts at Espírito Santo Investment Bank in a note to clients Tuesday. As well, they noted that Jazztel's top management and main shareholder support the bid, saying "the fact that the offer is fully paid in cash makes an upwards revision of the price unlikely and therefore we believe investors should take the offer."

In Paris, the CAC 40 shed 0.4% to 4,409.15. In London, the FTSE 100 fell 0.2% to 6,792.24, holding to losses after an unexpected decline in inflation in August.

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