By Sara Sjolin, MarketWatch

LONDON (MarketWatch) -- U.K. stocks led European markets lower on Wednesday, as investors worried that the Bank of England will hike rates sooner than previously expected after the central bank in its quarterly inflation report sounded more optimistic about the labor market.

Markets also keyed off weakness from the Asian session, where disappointment with the four-day Chinese Plenum sent stocks lower.

The Stoxx Europe 600 index dropped 0.6% to close at 319.82, building on a 0.6% loss from Tuesday.

"With the recent weakness expected given the strong run we have seen in Europe, we maintain that this represents a buying opportunity as the market still is looking to move higher into the year-end. Investors, with the current volatility, are now looking to trim positions quicker than they have in recent months, but we again remain confident of higher equity market levels over the coming weeks," said Atif Latif, director of trading at Guardian Stockbrokers, in emailed comments.

"Asset allocation towards equity inflow remains strong led by earnings upgrades," he added.

Among biggest decliners in Europe, the U.K.'s FTSE 100 index slid 1.4% to 6,630.00 after the Bank of England said the unemployment rate is more likely than not to drop to the crucial threshold of 7% by the third quarter of 2015, fueling fears the BOE will hike rates sooner than previously expected. The forecasts are based on market expectations that interest rates will rise in mid-2015, which would dampen growth in 2014 and 2015, the bank said.

The 7% threshold has become a key level for financial markets ever since the BOE released its August Inflation Report. That's when the bank laid out its forward-guidance framework and vowed to keep interest rates at a record low of 0.5%, at least until the joblessness rate falls to that level.

At the time, the central bank predicted unemployment would remain above 7% until 2016, but after recent upbeat data, markets started to price in a rate hike earlier than that.

Also out on Wednesday, the Office for National Statistics said the U.K. jobless rate fell to 7.6% between July and September, down from 7.7% in August. The pound (GBPUSD) traded at $1.6038, up from $1.5902 on Tuesday.

U.K. banks were among major decliners. Barclays PLC (BCS) lost 2.8%, HSBC Holdings PLC (HBC) fell 1.9%, and Lloyds Banking Group PLC (LYG) dropped 1.5%.

Banks were also on the decline elsewhere, with shares of UniCredit SpA down 4.5% in Milan, Commerzbank AG 2.4% lower in Frankfurt and Credit Agricole SA off 1.2% in Paris.

The broader European markets looked to Asia, where stocks declined after China's leaders failed to provide a clear direction on policy for the next decade at their four-day Plenum.

"What seems to be lacking was any real guidance on the outlook, but [they] did say that economic reforms will continue but details on more policy shifts were not forthcoming," Latif said.

U.S. stock also traded lower.

On the data front in Europe, Eurostat said industrial production in the euro zone fell 0.5% in September, partly reversing a 1% rise in August and missing analyst expectations.

Among country-specific indexes in Europe, Germany's DAX 30 index dropped 0.2% to 9,054.83 and France's CAC 40 index fell 0.6% to 4,239.94.

ICAP PLC rallied 4.1% after the company reported a 6% rise in first-half operating profit.

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