By Tom Fairless 

BRUSSELS--A high-profile European Union investigation into alleged tax sweeteners for multinationals spread to a fourth country on Tuesday, in a sign of the growing momentum behind the bloc's clampdown on corporate tax avoidance.

Policy makers have been scrambling to close loopholes in Europe's fragmented tax system that allow international groups to sidestep billions of euros in tax at a time of tough national austerity. Governments are hampered by a requirement that they all agree on any changes to the bloc's tax laws. But regulators in Brussels have stepped into the breach, opening a series of EU-wide probes that have gathered pace since widely publicized leaks late last year exposed the extent of tax avoidance in Luxembourg.

The EU's probes have so far ensnared four multinationals in three European countries-- Apple Inc. in Ireland, Amazon.com Inc. and Fiat SpA in Luxembourg and Starbucks Corp. in the Netherlands. If regulators' suspicions are confirmed, the companies could face back-tax demands worth hundreds of millions of dollars. All companies have denied receiving special treatment.

EU regulators said Tuesday they had opened a formal probe into whether Belgium gives an unfair tax break to multinational groups that isn't available to other firms. The concerns center on a provision in Belgian law that allows companies to deduct so-called "excess profits" from their tax bills--profits that allegedly result from the advantage of being part of a multinational group.

The scheme typically offers tax discounts of more than 50% and up to 90% for some multinational groups, apparently those "that move a substantial part of their businesses to Belgium," Margrethe Vestager, the EU's antitrust czar, said at a news conference.

She said the scheme appeared to overestimate the benefits of being part of a multinational, and could constitute "a serious distortion" of EU law. She declined to name any of the companies involved in the probe.

Belgium's Finance Minister Johan Van Overtveldt said the government will offer to cooperate fully in the probe and will seek a meeting with Ms. Vestager soon to "get a clear view on the objections and to offer clarifications where they are required."

He also said there were no indications that Belgium falls short of compliance with the standards of the Organization for Economic Co-operation and Development, which shapes international norms on taxation.

The EU's widening probe has focused on tax rulings, which are used to confirm the size of companies' future tax bills, to give company directors certainty as to their future outgoings. Regulators suspect that some tax rulings may have granted certain companies an advantage over others, which would be illegal under EU law.

The Belgian scheme "appears to grant substantial tax reductions only to certain multinational companies that would not be available to stand-alone companies," Ms. Vestager said. She said she wasn't convinced that the scheme helped companies to avoid being taxed twice by different governments for the same profits, and that it appeared to violate international tax norms established by the Organization for Economic Cooperation and Development, a club of rich countries.

Ms. Vestager, who took office as the EU's competition commissioner in November, ratcheted up the tax investigation significantly in December by announcing that all 28 EU governments would be required to provide a full list of companies that had received an advance tax ruling between 2010 and 2013.

In the wake of the EU's probes, Ireland has announced it will phase out a tax loophole known as the double-Irish, while Luxembourg is working on legislation to ensure its approval process for corporate tax rulings is more transparent.

Write to Tom Fairless at tom.fairless@wsj.com

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