Cyprotex PLC Expansion of Toxicology Capabilities
October 01 2014 - 2:00AM
RNS Non-Regulatory
TIDMCRX
Cyprotex PLC
01 October 2014
1(st) October 2014
Cyprotex PLC
("Cyprotex" or the "Company")
Expansion of Toxicology Capabilities
Cyprotex PLC (AIM:CRX; www.cyprotex.com), a specialist ADME-Tox
Contract Research Organisation (CRO), today announces the expansion
of its toxicology capabilities to include high content 3D tissue
analysis and advanced mitochondrial toxicity analysis.
The introduction of these capabilities at Cyprotex follows the
purchase of new instruments including a Thermo Scientific
ArrayScan(TM) XTI high content screening (HCS) platform and a
Seahorse XF(e) extracellular flux analyser. The investment in these
technologies will allow Cyprotex to provide greater specialisation
in key areas of interest in the field of toxicology and also enable
the Company to expand into pharmacological efficacy research (e.g.,
cancer and cardiovascular models), which will unlock potential from
new segments of the pharmaceutical market.
3D tissue models are becoming increasingly important in the
field of pharmaceutical and cosmetics research and product
development. Within the cosmetics field, 3D skin models are now
approved by the regulatory authorities as in vitro alternatives to
animal testing. These include MatTek's EpiDerm(TM) model which is
offered by Cyprotex for skin irritation, skin corrosion and skin
sensitisation testing. The characteristics of these 3D tissue
models are more relevant to the in vivo situation than 2D models,
and as their complexity evolves (e.g., using stem cells and/or
co-culture models) these models will become more predictive, and
ultimately, a critical tool in toxicological research. The
ArrayScan(TM) XTI HCS platform houses a confocal microscope
enabling high quality imaging of 3D cellular structures and is
complementary to the Cyprotex offering. By investing in this
technology Cyprotex maintains its position at the forefront of
scientific research in this field.
Changes in mitochondrial function play a role in the cause of
many disease conditions and are a key mechanism in drug induced
toxicity. The Seahorse XF(e) platform monitors two major energy
producing pathways of the cell which are linked to mitochondrial
function. The introduction of this service provides new
opportunities in multiple areas of research.
Dr Anthony Baxter, Cyprotex's Chief Executive Officer, comments
on the expansion of the toxicology facility:
"Understanding the mechanisms of toxicology of new therapeutics
remains a challenging area. Cyprotex is committed to research in
this field to help our clients bring safer drugs to the market. By
investing in the ArrayScan(TM) XTI and the Seahorse XF(e) we are
equipped with some of the latest cutting-edge technologies,
allowing us to expand our current offerings into key specialist
areas."
For further information:
Cyprotex PLC Tel: +44 (0) 1625 505
100
Dr Anthony Baxter, Chief Executive Officer ir@cyprotex.com
John Dootson, Chief Financial Officer www.cyprotex.com
Mark Warburton, Chief Operating Officer
and Legal Counsel
N+1 Singer (Nomad and broker to Cyprotex) Tel: +44 (0)20 7496 3000
Shaun Dobson shaun.dobson@n1singer.com
Jen Boorer jennifer.boorer@n1singer.com
www.n1singer.com
FTI Consulting Tel: +44 (0) 20 3727 1000
Simon Conway cyprotex@fticonsulting.com
Mo Noonan www.fticonsulting.com
Notes to Editors
Cyprotex PLC
Cyprotex is listed on the AIM market of the London Stock
Exchange (CRX). It has sites at Macclesfield and Alderley Park,
both of which are near Manchester in the UK, and at Watertown, MA
and Kalamazoo, MI in the US. The Company was established in 1999
and works with more than 900 partners within the pharmaceutical and
biotech industry, cosmetics and personal care industry and the
chemical industry. Cyprotex acquired Apredica and the assets of
Cellumen Inc. in August 2010 and the combined business provides
support for a wide range of experimental and computational ADME-Tox
and PK services, extending from early drug discovery through to IND
submission. The acquisition of the assets and business of CeeTox in
January 2014 has enabled Cyprotex to expand its range of services
to target the personal care, cosmetics and chemical industries. The
Company's core capabilities include high quality in vitro ADME
screening services, mechanistic toxicology and high content
toxicology screening services, including our proprietary
CellCiphr(R) toxicity prediction technology, predictive modelling
using PBPK and QSAR techniques, including Cloe(R) PK for in vivo PK
prediction, and a range of skin, ocular and endocrine disruption
services. For more information, see www.cyprotex.com.
This information is provided by RNS
The company news service from the London Stock Exchange
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