The board of directors of Pernix Therapeutics Holdings, Inc. (the "Company") has established November 15, 2017 as the date of the Company's 2017 Annual Meeting of Stockholders (the "2017 Annual Meeting"). Because the date of the 2017 Annual Meeting has been delayed by more than 30 days from the anniversary of the date of the Company's 2016 Annual Meeting of Stockholders (the "2016 Annual Meeting"), in accordance with Rule 14a-5(f) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), the Company is informing stockholders of such change.

Stockholders of record at the close of business on September 25, 2017 will be entitled to vote at the 2017 Annual Meeting. The 2017 Annual Meeting will be held at the Hyatt Morristown at Headquarters Plaza, 3 Speedwell Avenue, Morristown, New Jersey 07960 at 9:30 a.m., local time. Because the date of the 2017 Annual Meeting has been changed by more than 30 days from the anniversary of the date of the 2016 Annual Meeting, new deadlines have been set for submission of proposals by stockholders intended to be presented at the 2017 Annual Meeting and included in the Company's proxy statement for the 2017 Annual Meeting.

In accordance with Rule 14a-8 under the Exchange Act, if a stockholder wishes to present a proposal for inclusion in the proxy materials for the 2017 Annual Meeting, the Company's Corporate Secretary must receive written notice of such proposal at the Company's executive offices no later than the close of business on September 13, 2017, which the Company has determined to be a reasonable time before it expects to begin to print and send its proxy materials. Any such proposal must meet the requirements set forth in the rules and regulations of the Securities and Exchange Commission in order to be eligible for inclusion in the proxy materials for the 2017 Annual Meeting.

Pursuant to the advance notice procedures set forth in the Company's bylaws, stockholders who wish to bring business before the 2017 Annual Meeting outside of Rule 14a-8 or to nominate a person for election as a director (collectively, a "Proposal") must ensure that written notice of a Proposal is timely submitted to the Company. Pursuant to the Company's bylaws, in order for a Proposal to be properly submitted for presentation at the 2017 Annual Meeting, the Company's Corporate Secretary must receive written notice of such Proposal at the Company's executive offices prior to the close of business on September 4, 2017. All Proposals must contain the information specified in, and otherwise comply with, the Company's bylaws. Proposals must be delivered, by personal delivery or first class mail, to: Corporate Secretary, Pernix Therapeutics Holdings, Inc., 10 North Park Place, Suite 201, Morristown, New Jersey 07960.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.