By Tess Stynes 

Bristol-Myers Squibb Co. said its second-quarter revenue rose 7% with a boost from sales of its Opdivo immunotherapy drug and its hepatitis C franchise.

Revenue increased to $4.2 billion from $3.89 billion a year earlier. Excluding currency effects, the growth was 16%. Analysts polled by Thomson Reuters expected revenue of $3.72 billion.

The better-than-expected revenue growth contributed to the pharmaceutical company raising full year guidance. For the year, the company raised its per-share earnings estimate by a dime and now expects $1.70 to $1.80.

Bristol-Myers has gained attention as a leader in developing drugs that enlist the power of the immune system against cancer.

Opdivo, initially approved in late December, contributed sales of $122 million in its second quarter on the market, up sharply from $40 million in the first quarter. Sales of Yervoy, another skin-cancer immunotherapy, fell 8% from a year earlier to $296 million, amid a 21% decline in U.S. sales--partly owing to the growth of Opdivo for skin cancer in the U.S.

The company's hepatitis C franchise contributed sales of $479 million, boosted by recognition of $170 million previously deferred revenue in France related to an early access program.

The earnings report comes two days after Bristol-Myers said a late-stage trial of skin-cancer drug Opdivo was stopped early because the drug provided superior overall survival in advanced renal-cell carcinoma patients, further strengthening Bristol-Myer's position in immunotherapies. The drug also received U.S. regulatory approval to treat lung cancer earlier this year.

Also, in a recent study, a combination of Opdivo and the company's other skin cancer drug Yervoy delayed the progression of melanoma longer than either drug alone--results that could support wider use of both drugs.

In addition to clinical trials of the immunotherapies to treat other cancers, Bristol-Myers also has continued to expand its pipeline through deals, including April acquisition of immunotherapy drug developer Flexus and licensing of gene-therapy cardiovascular programs from uniQure.

Overall, Bristol-Myers reported a loss of $130 million, or eight cents a share, up from $333 million, or 20 cents a share, a year earlier. The latest period a charge of 48 cents a share related to the Flexus acquisition. Excluding such one-time items, per-share earnings rose to 53 cents from 48 cents. Analysts expected per-share profit of 36 cents.

Write to Tess Stynes at tess.stynes@wsj.com

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