By Neetha Mahadevan 
 

FRANKFURT--Germany's Bayer AG (BAYN.XE) on Thursday raised its full-year sales forecast despite a decline in first-quarter net profit that was largely due to higher research-and-development expenses and integration costs.

Net profit for the quarter ended March 31 fell 8.4% on the year to 1.30 billion euros ($1.45 billion), compared with EUR1.42 billion a year earlier, slightly missing analyst expectations of EUR1.36 billion. Earnings were held back by special charges of EUR244 million for the consolidation of the recently acquired over-the-counter business of Merck & Co. (MRK) and additional efficiency measures. Positive currency effects buoyed earnings by about EUR50 million

Earnings before interest, taxes, depreciation and amortization before special items--a figure watched closely by analysts--rose 9.6% to EUR3 billion from EUR2.74 billion a year earlier. Sales jumped 15% to EUR12.12 billion from EUR10.56 billion. Sales increased 2.7% after stripping off currency and portfolio effects.

For the full year, the German pharmaceutical company now expects sales of EUR48 billion to EUR49 billion compared with its previously forecast EUR46 billion, helped by favorable foreign-exchange conditions. Ebitda before special items is predicted to increase by a high-teen percentage compared with its previous forecast of a low- to mid-teen-percentage increase.

Bayer Chief Executive Marijn Dekkers has been steering the company to refocus on its core health-care and agricultural businesses, while preparing to shed its high-tech plastics business through a flotation by mid-2016 at the latest.

Since taking the helm five years ago, Mr. Dekkers has presided over the launch of five new blockbuster drugs and beefed up the group's over-the-counter drug business with the $14.2 billion acquisition last year of U.S.-based Merck & Co.'s consumer-care division.

In the first three months, the combined sales its key drugs--anticoagulant Xarelto, eye medicine Eylea, cancer drugs Stivarga and Xofigo, and pulmonary hypertension drug Adempas--jumped 50% to EUR898 million, while the products acquired from Merck added EUR495 million to the health-care business. However, earnings at its crop-science business suffered due to weak market conditions in North and South America. The Leverkusen-based company said the MaterialScience unit posted earnings growth of 16% in the first quarter due to low raw-material costs, but sales declined amid fall in selling prices.

Bayer is on track to spin off the $10 billion MaterialScience business, either directly to shareholders or through an initial public offering, the company said.

Mr. Dekkers has said the company would decide on the best route in the second half of 2015, but has suggested he would prefer an IPO in order to generate cash to pay down Bayer's EUR20 billion in debt. The division's financial chief recently told The Wall Street Journal that a spinoff will bring down the unit's costs by providing it more flexibility, mitigating the need to push through major investments once it is independent.

Write to Neetha Mahadevan at neetha.mahadevan@wsj.com

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