Angle PLC CTCs harvested with Parsortix grown in laboratory (0019T)
October 09 2017 - 2:02AM
UK Regulatory
TIDMAGL
RNS Number : 0019T
Angle PLC
09 October 2017
For immediate release 9 October 2017
ANGLE plc ("the Company")
CIRCULATING TUMOUR CELLS, HARVESTED FROM BLOOD, GROWN IN THE
LABORATORY FOR THE FIRST TIME
Heinrich Heine University researchers demonstrate that CTCs
harvested with Parsortix(TM) from leukapheresis blood product can
be cultured
Cultured cells continue to proliferate several months after
Parsortix(TM) harvest
ANGLE plc (AIM:AGL OTCQX:ANPCY), a world-leading liquid biopsy
company, today announces that one of its customers has successfully
grown circulating tumor cells (CTCs) harvested by Parsortix(TM) in
the laboratory. This is the first time the ability to culture CTCs
harvested from blood using Parsortix(TM) has been published. The
CTCs were isolated from diagnostic leukapheresis (DLA) blood
product.
The cells grown in culture harbour genomic abnormalities that
confirm their malignant origin. Most of the aberrations were
identical to those detected in the uncultured CTCs from the same
patient. The cultured cells continue to proliferate several months
after Parsortix(TM) harvest, providing a renewable population of
cells for ongoing research and investigation outside the
patient.
The customer, a research group from the Heinrich Heine
University, Düsseldorf, Germany, presented their results at
Europe's leading circulating tumour cell (CTC) conference, the
Third International Advances in Circulating Tumour Cells (ACTC)
Symposium (Rhodes, Greece, 4 to 7 October 2017).
ANGLE Founder and Chief Executive, Andrew Newland,
commented:
"This is the first time that a patient's CTCs harvested by
Parsortix(TM) have been successfully cultured. The Parsortix(TM)
system's capability to harvest living, viable cancer cells is a key
differentiator and we believe this will lead to new avenues of
research using Parsortix(TM) ."
Dr Hans Neubauer, University Hospital and Medical Faculty of the
Heinrich-Riche University of Duesseldorf commented:
"The use of diagnostic leukapheresis blood product provides
larger numbers of CTCs than a normal blood sample. The
Parsortix(TM) system provides an easy solution for harvesting these
CTCs keeping the cells alive and undamaged. The workflow we have
developed to culture these cells will allow an intensification of
research into new diagnostic and therapeutic solutions."
For further information ANGLE:
ANGLE plc +44 (0) 1483 343434
Andrew Newland, Chief Executive
Ian Griffiths, Finance Director
finnCap Ltd (NOMAD and Joint
Broker)
Corporate Finance - Adrian
Hargrave, Simon Hicks, Kate
Bannatyne
Corporate Broking - Alice Lane,
Nikita Jain +44 (0)20 7220 0500
WG Partners (Joint Broker)
Nigel Barnes +44 (0) 203 705 9318
Nigel Birks +44 (0) 203 705 9316
FTI Consulting
Simon Conway, Mo Noonan, Stephanie
Cuthbert +44 (0) 203 727 1000
Kimberly Ha (US) +1 212 850 5612
For Frequently Used Terms, please see the Company's website on
http://www.angleplc.com/the-parsortix-system/glossary/
This announcement contains inside information.
Notes for editors
About ANGLE plc www.angleplc.com
ANGLE is a world-leading liquid biopsy company commercialising a
disruptive platform technology that can capture cells circulating
in blood, such as cancer cells, even when they are as rare in
number as one cell in one billion blood cells, and harvest the
cells for analysis.
ANGLE's cell separation technology is called the Parsortix(TM)
system and it enables a liquid biopsy (simple blood test) to be
used to provide the cells of interest. Parsortix(TM) is the subject
of granted patents in Europe, the United States, Canada, India,
China, Japan and Australia and three extensive families of patents
are being progressed worldwide. The system is based on a
microfluidic device that captures live cells based on a combination
of their size and compressibility. Parsortix(TM) has a CE Mark for
Europe and FDA authorisation is in process for the United
States.
ANGLE has established formal collaborations with world-class
cancer centres. These Key Opinion Leaders are working to identify
applications with medical utility (clear benefit to patients), and
to secure clinical data that demonstrates that utility in patient
studies. Details are available here
http://www.angleplc.com/the-company/collaborators/
The analysis of the cells that can be harvested from patient
blood with ANGLE's Parsortix(TM) system has the potential to help
deliver personalised cancer care offering profound improvements in
clinical and health economic outcomes in the treatment and
diagnosis of various forms of cancer.
The global increase in cancer to a 1 in 3 lifetime incidence is
set to drive a multi-billion dollar clinical market. The
Parsortix(TM) system is designed to be compatible with existing
major medtech analytical platforms and to act as a companion
diagnostic for major pharma in helping to identify patients that
will benefit from a particular drug and then monitoring the drug's
effectiveness.
As well as cancer, the Parsortix(TM) technology has the
potential for deployment with several other important cell types in
the future.
ANGLE stock trades on the AIM market of the London Stock
Exchange under the ticker symbol AGL and in New York on the OTC-QX
under the ticker symbol ANPCY. For further information please
visit: www.angleplc.com
This information is provided by RNS
The company news service from the London Stock Exchange
END
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