Allergy Therapeutics PLC Positive Dust Mite Study Results
July 06 2015 - 2:00AM
RNS Non-Regulatory
TIDMAGY
Allergy Therapeutics PLC
06 July 2015
6 July 2015
Allergy Therapeutics plc
("Allergy Therapeutics" or "the Company")
Positive Dust Mite Study Results
Allergy Therapeutics, the fully integrated specialty
pharmaceutical company specialising in allergy vaccines, today
announces positive results from its prospective observational
Acarovac Plus clinical study for the treatment of house dust mite
allergy. Acarovac Plus is being developed as one of the Company's
new generation of products to address the perennial allergy market
with innovative and short-course therapies.
At the Adjuvants in Allergy conference over the past weekend,
Dr. Albert Roger, Director of the Allergy Unit at Universitari
Hospital Germans Trias Pujol, Badalona Spain, presented the results
of a prospective observational one-year follow-up study, comparing
the safety, tolerability and long-term effectiveness of Acarovac
Plus using Dermatophagoides pteronyssinus (house dust mite) in 30
adult patients with allergic rhinitis and/or asthma. Acarovac Plus
has been designed to administer maintenance doses every 6-8 weeks,
reducing the number of annual injections required and providing a
natural, biodegradable, alternative depot(1) vaccine.
Tolerability of Acarovac Plus was demonstrated with no reported
adverse events. The effectiveness of Acarovac Plus was measured in
patients using a nasal provocation test, which evaluates the
sensitivity of each patient to mite allergens. Nasal airway
assessments were performed using peak nasal inspiratory flow
measurements. In summary, a reduction in symptom scores of >50%
were observed during follow up visits after one year. Immunological
markers were also assessed and showed significant improvements in
antibody IgG4 and anti-inflammatory IL-10 molecules, indicating
tolerance induction in patients after one year of treatment.
A validated patient satisfaction survey provided information
that was reflective of the clinical findings from the study. A high
degree of overall patient satisfaction was observed, which
encompassed significant improvements in scores after one year in
relation to overall effectiveness and convenience of the treatment.
This reinforces one of the main objectives of Allergy Therapeutics
in improving patient life by producing effective treatments, while
at the same time reducing the discomfort of injections, improving
compliance and adherence of allergy immunotherapy products.
Further to the efficacy noted for Acarovac Plus(2) , Allergy
Therapeutics is developing Acarovac Quattro, an ultra-short course
therapy utilising the adjuvant monophosphoryl lipid A (MPL), which
is used in the Company's successful Pollinex Quattro product range
currently in late stage development in Europe and the US.
Dr Roger, principal investigator for the study, said:
"The successful clinical results in the one year follow-up study
clearly demonstrate the effective treatment of house dust mite
allergy by Acarovac Plus. We also observed significant decreases in
symptom scores and improvement in nasal sensitivity immediately
after the up dosing phase of one month. Acarovac Plus therapy not
only led to a high rate of patient satisfaction early in treatment,
but also the convenient maintenance regime of injections every 6
weeks has the potential to improve the adherence and compliance
with the vaccine regime that is essential for a successful
treatment."
Manuel Llobet, Chief Executive Officer, commented:
"Following the continued successful development of the Pollinex
Quattro product range addressing the seasonal segment of the
allergy market, we now intend to extend this innovative franchise
into developing perennial allergy vaccines. On the back of these
promising results for Acarovac Plus in ameliorating the symptoms of
house dust mite allergy, we have embarked on the development of an
ultra-short course version utilising the adjuvant MPL. We expect
that Acarovac Quattro will have all the benefits of both Pollinex
Quattro technology platform coupled with the efficacy seen with
Acarovac Plus. Over 20% of the population in both Europe and the US
have an allergic reaction to house dust mites and so an effective
short course allergy vaccine will be an important and potentially
valuable addition to our product range"
- Ends -
For further information:
+44 (0) 1903 845
Allergy Therapeutics 820
Manuel Llobet, Chief Executive Officer
Ian Postlethwaite, Finance Director
+44 (0) 20 7886
Panmure Gordon 2500
Freddy Crossley / Peter Steel / Duncan Monteith,
Corporate Finance
Tom Salvesen, Corporate Broking
+44 (0) 20 3727
FTI Consulting 1000
Simon Conway
Victoria Foster Mitchell
Note to editors:
About Allergy Therapeutics
Allergy Therapeutics is a specialty pharmaceutical company
focused on allergy vaccination. It has a growing business achieving
revenue in the last financial year of GBP42 million mainly in
Europe through its own sales and marketing infrastructure and
further afield through distributors.
Acarovac Plus
Acarovac Plus has been Allergy Therapeutics strongest growing
treatment in Spain this year and it is being developed as one of
the Company's new generation of products developed to address the
perennial allergy market with innovative and short-course
therapies.
Acarovac Quattro
Pollinex Quattro is the only ultra-short course immunotherapy
utilising MPL (Monophosphoryl Lipid A) and MCT (Microcrystalline
Tyrosine), a natural, biodegradable depot adjuvant for the
treatment of seasonal allergic rhinitis. Building on the principles
of the Pollinex Quattro formulation, Allergy Therapeutics have
developed controlled and standardised allergoids for the treatment
of perennial allergic conditions, such as house dust mite combined
with MCT, which is already available for the treatment of dust mite
allergy in parts of Europe (Acarovac Plus). Based upon the efficacy
noted for Acarovac Plus(2) , an alternative ultra-short course
therapy utilising MPL is being developed.
References
1. An injection, usually subcutaneous or intramuscular, of a
pharmacological agent, which releases its active compound in a
consistent way over a long period of time
2. Roger, A., Depreux, N., Jurgens Y., Heath M, Garcia G.,
Skinner M, A novel and well tolerated mite allergoid subcutaneous
immunotherapy: Evidence of clinical and immunologic efficacy.
Immunity, Inflammation and Disease, 2014; 2 (2); 92-98
This information is provided by RNS
The company news service from the London Stock Exchange
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