TIDMAGY

RNS Number : 3269R

Allergy Therapeutics PLC

08 March 2016

Allergy Therapeutics plc

("Allergy Therapeutics" or "the Company")

Interim Results for the six months ended 31 December 2015

Allergy Therapeutics plc (AIM:AGY), the fully integrated specialty pharmaceutical company specialising in allergy vaccines, announces unaudited interim results for the six months ended 31 December 2015.

Highlights

Financial highlights

-- Revenue increased by 12% at constant currency to GBP31.5m (H1 2015: GBP28.2m)* and reported revenue increased by 3% to GBP29.0m (H1 2015: GBP28.2m)

-- R&D expenditure increased to GBP6.5m (H1 2015: GBP1.1m) as the two Phase II studies in Germany and the US were successfully progressed

-- Fundraising of GBP11.5m (gross) successfully completed with placing of 41,005,500 ordinary shares in the Company to invest in new product development, strengthen the balance sheet and accelerate growth

   --      Cash balance bolstered to GBP33.2m (H1 2015: GBP8.0m) 

Products and pipeline highlights

   --      Increasing market share in all major markets 
   --      Spanish Alerpharma acquisition fully integrated 

-- US Phase II study for GrassMATAMPL (marketed in Europe as Pollinex Quattro Grass product) initiated in December 2015 - on track for data read out in H2 2016

   --      PQ Birch204 Phase II study patient enrolment completed - results expected in H2 2016 

-- Acquisition of Virus Like Particles ("VLP") technology licence for the development of a potential new injectable vaccine immunotherapy treatment for allergy sufferers, with peanut as the lead project

   --      Positive house dust mite study results for Acarovac - July 2015 

Post period end highlights

   --      US Grass MATAMPL study fully recruited according to plan in February 2016 

Commenting on the interim results, Manuel Llobet, Chief Executive Officer, said:

"The first half of this year has seen continued momentum with our product sales continuing to outperform the market with further market share gains across Europe. We delivered 12% revenue growth at constant currency. This double-digit growth against a (broadly) flat market has been driven by a combination of our winning proposition of lifestyle enhancing short course aluminium-free vaccines boosted by our successful sales strategy.

"Our business is gaining significant scale and momentum in Europe through both organic and acquisitive growth and we expect this to continue as we further invest in our commercial infrastructure and prepare to take our products over to the US. We eagerly await the data from two ongoing Phase 2 studies for GrassMATAMPL and PQ Birch204 which are both due to report later in 2016. "

* Constant currency uses prior year weighted average exchange rates to translate current year foreign currency denominated revenue to give a year on year comparison excluding the effects of foreign exchange movements. See table in financial review for an analysis of revenue.

Joint Statement from the Chairman and Chief Executive Officer

Operating Review

Overview

During the first six months of the year, the Company's revenues grew 12% (at constant currency) compared to 11% at the end of June 2015, and against flat or low growth markets in Europe. Allergy Therapeutics' robust level of double digit top line growth at constant currency is due to the benefits offered to patients of a short course, aluminium-free, therapy which is enabling the Company to outperform its competitors and grow its market share in Europe. Geographically, the major contributing markets to the Company's growth have been Germany and Spain, followed by The Netherlands, the UK and Austria.

Pollinex Quattro - increasing market share in Europe and paving the way towards the US market

The success of Allergy Therapeutics' immunotherapy concept is a key driver of shareholder value creation. Future sales growth will further de-risk the Company's strategic objective of significantly increasing its addressable market, as it prepares to replicate Pollinex Quattro's commercial success in Europe through its launch in the US market. Given that Pollinex Quattro is already established in Europe, the Board and management team are confident of commercial success in the US, where Pollinex Quattro will enjoy first mover advantage in the seasonal segment, and high barriers to entry, fulfilling a clearly defined market need.

The clinical development programme for Pollinex Quattro Grass in the US is now progressing well. In December 2015, Allergy Therapeutics announced the initiation of the Phase II study (G204) for grass allergy and the Company continues to expect to file for US FDA approval at the end of 2018. Following approval, the launch of Pollinex Quattro Grass in the US would enable the Company to enter into a market for specific immunotherapy potentially worth $2 billion. Like its core adoptive European markets, the US allergy immunotherapy market has historically been serviced by subcutaneous rather than sublingual compounded vaccines. Allergy Therapeutics is therefore confident that the availability of an FDA-approved subcutaneous vaccine will facilitate a fast penetration and broad acceptance of the product among the prescriber base.

Regulatory affairs - moving the pipeline forward

Allergy Therapeutics' regulatory department has made good progress throughout the period, including with the German TAV (Therapy Allergy Ordinance) process for the Pollinex Quattro Birch (PQB) vaccine clinical development programme. In November, the Company announced completion of patient enrolment of the PQB 204 Phase II study with headline data expected in the second half of 2016. The target sample of 350 patients was successfully achieved and the active phase of the study is now complete. The endpoint of the trial is the change in total rhinoconjunctivitis symptoms score after treatment relative to the placebo. The optimal dose established from the trial will be selected and examined further in the PQ Birch phase III study, due to start in the first quarter of 2017. The completion of the phase III study is expected to fulfil the requirements for the initial clinical programme under the TAV of the Paul Ehrlich Institute (PEI), the German Biologics Agency, and lead to marketing authorisation approval of this subcutaneous immunotherapy (SCIT) in 2019. Allergy to birch pollen is a significant health issue with around 6 per cent of the population in Europe being skin-prick positive for the allergen.

The Company has maintained a proactive dialogue with the regulatory authorities in its key markets including Germany, Italy, Spain and Austria.

Progress with new high value projects

Allergy Therapeutics' organic growth strategy has been enhanced during the period by a number of high value projects which will further leverage the Company's operational infrastructure and scientific know-how. These projects seek to replicate the success of the Company's short course and ultra-short course immunotherapies in other related areas such as Perennial Allergic Rhinitis and Food Allergies, and develop further vaccine formulations using the Micro Crystalline Tyrosine (MCT) adjuvant system. These projects will open up new areas of the immunotherapy treatment market and increase the Company's total addressable market, fivefold, to c. $15 billion p.a., including:

   --           VLP - peanut allergy 

Taking the newly-acquired Virus like Particles (VLP) technology license for the development of Polyvac Peanut, a new potential injectable vaccine immunotherapy treatment for allergy sufferers, into Phase I clinical trials. As previously announced, food allergy represents a significant and strategically important new area for the Company, with peanut allergy treatments alone being an $8 billion p.a. addressable market, globally.

Peanut allergy affects an increasing number of sufferers with a significant unmet need. Polyvac Peanut could be the first subcutaneous vaccine to address this segment, delivering a sustained immunological response and bringing relief to peanut allergy sufferers around the world.

   --           Acarovac Quattro - dust mite allergy 

Progressing the in-house development of Acarovac Quattro, a treatment for perennial dust mite allergy, through Phase I clinical trials and to launch in Spain on a named patient basis targeted for 2017. Acarovac Quattro uses the same technological platform as Pollinex Quattro and will bring to the perennial segment unmatchable attributes in terms of patient convenience. The product will reduce the current number of annual injections required compared to current products in the market, providing a unique, natural, biodegradable, alternative depot vaccine, boosted by the MPL adjuvant Monophosphoryl Lipid A, which Allergy Therapeutics holds exclusive rights to use in allergy vaccines. The development of Acarovac Quattro builds on the success of the already launched Acarovac Plus vaccine in the Spanish market as a Named Patient Product (NPP).

In July, during the Adjuvants in Allergy Conference in Amsterdam, Dr Albert Roger, Director of the Allergy Unit at Hospital Germans Trias i Pujol, presented the results of a prospective observational one-year follow-up study comparing the safety, tolerability and long-term effectiveness of Acarovac Plus using Dermatophagoides pteronyssinus (house dust mite) in 30 patients with allergic rhinitis and/or asthma. Tolerability was demonstrated, along with a reduction in symptom scores of more than 50 per cent during follow up visits after one year. This novel efficacious mite SCIT product underpins EU wide product development plans for Acarovac Quattro. House Dust Mite is the world's most common cause of allergy and is estimated to affect over 90 million people in Europe, North America and Japan alone. With a $3-4 billion per annum global addressable market, house dust mite represents another significant and strategically important area for the Company.

   --           Immunomodulators and adjuvants 

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Various feasibility studies are in progress in the fields of immunomodulators and adjuvants; specifically including the use of symbiotics in allergy response and MCT as an adjuvant system with other vaccines for treating infection and illness. The Company presented data relating to the use of this patented adjuvant technology at the World Vaccine Congress in November 2015. The data supported the use of depot adjuvant MCT in novel vaccine candidate formulations including malaria and influenza. The data was established following active collaboration with Oxford University, The Jenner Institute and Public Health England.

Inorganic growth strategy and successful integration of M&A

The Company's acquisitive growth strategy has continued to progress on track, with the successful integration of the recently acquired Spanish company, Alerpharma, into the Company's Spanish Operations. Alerpharma is now fully integrated, and the optimal operational platform has been established for Allergy Therapeutics to become a leading company in the important specific immunotherapy Spanish market.

The Company continues to assess a number of inorganic opportunities against a rigid set of qualifying criteria.

Equity fundraising

In order to capitalise on the continued momentum across the business, the successful organic and acquisitive growth strategies and management's objective of further accelerating the pace of increasing market share the Company completed a fundraise in November 2015, raising GBP11.5m (before costs) by placing 41,005,500 New Shares, representing approximately 7.5 per cent of the Company's existing ordinary share capital. The placing was oversubscribed and will enable Allergy Therapeutics to capitalise on growth opportunities and diversify into adjacent and complementary areas, with the aim of achieving a five-fold step-change in the Company's total addressable market to approximately $15 billion p.a. as detailed above.

Increased manufacturing efficiencies and automation

Additionally, work has been ongoing in the Company's manufacturing facilities to enhance processes for efficiency and compliance. The use of bar codes to check and reconcile named patient vaccines, controlled issue to packing lines and a redesigned diagnostic despatch process have all been implemented. Allergy Therapeutics also recorded its first successful batch release by the PEI for machine-filled Pollinex Quattro Tree with Grass. This enables the Company to transfer a large percentage of manufacturing for Pollinex Quattro away from a manual process and this switch will be made starting in autumn 2016.

Pride in patient care

The Company has worked to ensure as many of its diagnostic licences as possible can be retained in Germany. This retains its intellectual property and has enabled the Company to reintroduce 31 allergens during 2015 which are now available for all markets. Having a broad range of well-standardised and characterised allergy diagnostics has been a strategic priority for Allergy Therapeutics in order to provide the best possible service to its customers. Pioneering works on development of the proteomics and allergomics concepts (published in the World Allergy Journal in August 2015) underpins the Company's track record in the scientific advancement of its product portfolio, reinforcing its focus on patient care and commitment to invest both in existing and future products to ensure patients receive the treatment they deserve.

Excellence in customer service

The Company's Supply Operations in Worthing have been working on customer service to ensure the best possible response for customers. This was one of the Company's key strategic objectives in 2014-15 and it has culminated in 100 per cent customer service satisfaction in November 2015, with an average customer service achieved of 99 per cent for named patient vaccines delivered on time. The Company has been servicing increased demand and has had no out of stock allergens for vaccine manufacture during the first half year. The Company has targeted on time delivery, which include Pollinex or Venomil to affiliates/distributors, at 99-100 per cent and is fulfilling this objective.

Financial Review

Reported revenues for the first half of the financial year were GBP29.0m (H1 2015: GBP28.2m), representing a growth of 3 per cent, despite low to flat markets in Europe, reported after taking into account currency movements; the negative impact on revenues from the weakening Euro being GBP2.5m. At constant currency, revenue growth is 12 per cent for the period, with first half revenues of GBP31.5m (H1 2015: GBP28.2m). This double digit sales growth has been driven primarily by the Company's improving trading performance as it continues to increase its market share in all of its main markets, supported by the acquisition of Alerpharma in June 2015 which added approximately 3 per cent of the reported sales growth.

A reconciliation between reported revenues and revenues in constant currency is provided in the table below:

 
                                                               6 months to         6 months to     Increase   Increase 
                                                                 31-Dec-15           31-Dec-14 
                                                                      GBPm                GBPm         GBPm          % 
 
 Revenue                                                              29.0                28.2          0.8         3% 
 Adjustment to retranslate to prior year foreign exchange              2.5                   - 
 rate 
------------------------------------------------------------  ------------  ------------------  -----------  --------- 
 Revenue at constant currency                                         31.5                28.2          3.3        12% 
 Add rebates at constant currency                                      2.6                 2.0          0.6 
------------------------------------------------------------  ------------  ------------------  -----------  --------- 
 Gross revenue at constant currency                                   34.1                30.2          3.9        13% 
 
 

As in previous years, owing to the seasonality of the pollen allergy market, between 60 per cent to 70 per cent of Allergy Therapeutics' revenues are generated in the first half of the financial year and, as a consequence, the Company typically records profits in the first half of the year and losses in the second half.

Cost of goods sold increased marginally in the period to GBP7.3m (H1 2015: GBP6.8m), due mainly to inflationary increases and the acquisition of Alerpharma. Gross profit improved to GBP21.6m (H1 2015: GBP21.4m), which represents a gross margin of 75 per cent (H1 2015: 76 per cent), a good result given the foreign exchange impact on sales.

Distribution costs of GBP9.8m (H1 2015: GBP8.9m) were higher than the previous period after taking into account impacts on overseas costs as Alerpharma costs were included for the first time and a number of sales representatives have been added throughout Europe to help accelerate revenue growth, less the positive impact of foreign exchange. Administration expenses of GBP3.9m (H1 2015: GBP3.9m) remained the same, and included the benefit of the stronger dollar revaluing US dollar deposits favourably by GBP1.1m, less the negative impact of the fair valuation of Euro denominated derivatives (GBP0.8m).

Research and development costs increased to GBP6.5m (H1 2015: GBP1.1m), as the two Phase II studies in Germany and the US were progressed within the period.

The tax charge in the period of GBP0.2m (H1 2015: GBP0.1m) relates to overseas subsidiaries and the increase reflects the growing profitability of the subsidiaries.

Property, plant and equipment increased by GBP2.0m to GBP8.8m as a result of the acquisition of Alerpharma. Excluding this, the depreciation charge for the period broadly equalled new equipment purchases. Goodwill increased to GBP3.1m with the acquisition of Alerpharma (H1 2015: GBP2.5m), whilst other intangible assets have risen by GBP0.7m, again mainly as a result of the Alerpharma purchase.

Total current assets excluding cash have increased by GBP0.3m to GBP14.0m (H1 2015: GBP13.7m). This is mainly due to an increase in inventory.

Retirement benefit obligations, which relate solely to the German pension scheme, decreased slightly to GBP7.5m (H1 2015: GBP7.6m) as a result of the movement in the GBP:EUR exchange rate.

Net cash generated by operations remained positive, although was significantly lower as a result of increased R&D spending, with a reported inflow of GBP0.6m (H1 2015: GBP6.5m).

Financing

In November 2015, 41,005,500 new ordinary shares of 0.1 pence each ("Ordinary Shares") were placed with investors raising proceeds of GBP11.5m before expenses (GBP11.0m net). The Company will use the placing proceeds to invest in new product development with a view to achieving a step change in the size of its total addressable markets, strengthen its balance sheet and accelerate growth.

The Group had no debt on its balance sheet at the close of the financial year other than the loans acquired as a result of the Alerpharma acquisition (GBP1.6m). The seasonal overdraft had been fully repaid in November 2015. The Company expects to renew its banking facilities when they are due for review in April 2016.

The Directors believe that the Group will have adequate facilities for the foreseeable future and accordingly they have applied the going concern principle in preparing these interim financial statements.

Movements in the currency markets between the respective values of the Euro and Sterling have an effect on the Company's operations. The Company manages its cash exposure in this respect by foreign currency hedges. Over 90 per cent of our gross sales are denominated in Euros whereas approximately 50 per cent of costs are incurred in the United Kingdom and denominated in Sterling.

Other Matters

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As disclosed in Note 4 (Contingent liabilities), on 23 February 2015, the Company received notification that The Federal Office for Economics and Export ("BAFA") had made a decision to reverse their preliminary exemption to the increased manufacturers rebate in Germany for the period July to December 2012. The Company was granted a preliminary exemption to the increased rebate for this period by BAFA in 2013. The Company recognised revenue of EUR1.4m (GBP1.1m) against this exemption in the year ended 30 June 2013. All other preliminary exemptions (granted for periods up to 30 June 2012) have previously been ratified as final by BAFA. After taking legal advice, the Company has lodged an appeal against this decision and is confident that the exemption will be re-instated. Therefore, as at 31 December 2015, no provision has been recognised for the repayment of the rebate refund. This position will be kept under review.

The European Commission has concluded its investigation into whether the exemption of pharmaceutical manufacturers from the increase in rebates in Germany constitutes state aid. The European Commission has determined that the exemptions do not constitute state aid. Subsequent to this announcement, the Group has been advised that an appeal has been lodged at the EU Court against this decision. If successful, and the exemptions are determined to be illegal state aid, then the exemption refunds may have to be repaid. The maximum sum to be repaid would be approximately GBP5m (including the GBP1.1m referred to above); however, the Group considers this to be an unlikely outcome and consequently has not recognised any contingent liability.

Outlook

Allergy Therapeutics' lifestyle-enhancing short course and ultra-short course products continue to gain market share in Europe and the Company remains on course with its plan to become a leading player in the global specific immunotherapy market. Whilst its main markets are exhibiting flat or low growth, the Company believes it can continue to outperform competitors and keep increasing market share, aiming to grow its European business at low double digit rate over the coming years, supported by an enhanced commercial infrastructure and expanding product portfolio.

In the US, following the GBP20m (net of expenses) fundraising in March 2015, the Company has restarted clinical development plans, aiming to enter the US market following FDA approval in 2019, thereby becoming the first company to launch a subcutaneous vaccine in the seasonal segment of the US allergic rhinitis market.

The Company's US commercialisation strategy is where significant growth potential lies and, with a reinforced balance sheet, the Company is well placed to build a fast growing, profitable international allergy solutions business.

We look forward to the future with confidence.

Peter Jensen

Chairman

Manuel Llobet

Chief Executive Officer

7 March 2016

 
 ALLERGY THERAPEUTICS PLC 
 
 
 
 Consolidated income statement 
                                      Note   6 months    6 months     12 months 
                                                 to          to           to 
                                               31 Dec      31 Dec       30 Jun 
                                               2015        2014          2015 
                                              GBP'000     GBP'000      GBP'000 
                                        2 
                                             unaudited   unaudited     audited 
 
 Revenue                                        28,959      28,183         43,230 
 Cost of sales                                 (7,328)     (6,796)       (12,179) 
                                            ----------  ----------  ------------- 
 
 Gross profit                                   21,631      21,387         31,051 
 
 Sales, marketing and distribution 
  costs                                        (9,842)     (8,874)       (17,060) 
 
 Administration expenses 
  - other                                      (3,879)     (3,926)       (10,218) 
 Research and development 
  costs                                        (6,537)     (1,065)        (3,121) 
                                            ----------  ----------  ------------- 
 Administration expenses                      (10,416)     (4,991)       (13,339) 
 Other income                                        -           -             73 
 
 Operating profit                                1,373       7,522            725 
 
 Finance income                                     84           1            147 
 Finance expense                                 (154)       (110)          (218) 
                                            ----------  ----------  ------------- 
 
 Profit before tax                               1,303       7,413            654 
 Income tax                                      (249)       (108)          (546) 
                                            ----------  ----------  ------------- 
 
 Profit for the period                           1,054       7,305            108 
                                            ==========  ==========  ============= 
 
 
 Earnings per share                    3 
 Basic (pence per share)                         0.19p       1.62p          0.02p 
 Diluted (pence per share)                       0.18p       1.54p          0.02p 
 
 
 
 Consolidated statement of 
  comprehensive income 
                                               6 months    6 months    12 months 
                                                   to          to          to 
                                                 31 Dec      31 Dec      30 Jun 
                                                 2015        2014        2015 
                                                GBP'000     GBP'000     GBP'000 
                                               unaudited   unaudited    audited 
 
 Profit for the period                             1,054       7,305         108 
 Items that will not be reclassified 
  subsequently to profit or 
  loss: 
 Remeasurement of net defined 
  benefit liability                                (255)     (1,137)       (932) 
 
   Remeasurement of investments-retirement 
   benefit 
   assets                                           (51)          44           8 
 
   Items that will be reclassified 
   subsequently to profit or 
   loss: 
 Exchange differences on 
  translation of foreign operations                  366        (35)       (119) 
 
 
 Total comprehensive income/ 
  (loss)                                           1,114       6,177       (935) 
                                              ==========  ==========  ========== 
 
 
 
 
      Consolidated balance sheet 
                                                   31 Dec      31 Dec     30 Jun 
                                                   2015        2014        2015 
                                                  GBP'000     GBP'000    GBP'000 
                                                 unaudited   unaudited   audited 
      Assets 
      Non-current assets 
  Property, plant and equipment                      8,787       6,785      8,750 
  Intangible assets - Goodwill                       3,053       2,454      2,980 
  Intangible assets - Other                          1,925       1,192      2,020 
  Investment - Retirement 
   benefit asset                                     3,451       3,348      3,160 
      Deferred taxation asset                            -         174          - 
 
  Total non-current assets                          17,216      13,953     16,910 
 
      Current assets 
  Trade and other receivables                        7,141       7,236      5,060 
  Inventory                                          6,826       6,318      6,747 
      Cash and cash equivalents                     33,206       7,985     21,199 
                                                         3         163        783 
      Derivative financial instruments 
 
  Total current assets                              47,176      21,702     33,789 
 
  Total assets                                      64,392      35,655     50,699 
                                                ----------  ----------  --------- 
 
      Liabilities 
      Current liabilities 
  Trade and other payables                         (7,906)     (6,227)    (7,169) 
  Current borrowings                                 (262)        (49)      (251) 
 
  Total current liabilities                        (8,168)     (6,276)    (7,420) 
 
  Net current assets                                39,008      15,426     26,369 
                                                ----------  ----------  --------- 
 
      Non current liabilities 
  Retirement benefit obligation                    (7,465)     (7,546)    (6,755) 
  Deferred taxation                                  (296)       (128)      (298) 
  Non current provisions                             (252)       (217)      (211) 
      Other non current liabilities                  (113)           -      (113) 
   Long term borrowings                            (1,378)           -    (1,433) 
                                                ----------  ----------  --------- 
 
  Total non current liabilities                    (9,504)     (7,891)    (8,810) 
 
  Total liabilities                               (17,672)    (14,167)   (16,230) 
 
  Net assets                                        46,720      21,488     34,469 
                                                ==========  ==========  ========= 
 
      Equity 
      Capital and reserves 
  Issued capital                                       597         420        556 
  Share premium                                    102,389      67,750     91,463 
  Merger reserve - shares 
   issued by subsidiary                             40,128      40,128     40,128 
  Reserve - shares held by 
   EBT                                                  67          67         67 

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  Reserve - share based payments                       761         667        591 
      Reserve - convertible loan                         -       3,652          - 
       notes 
  Revaluation reserve                                1,178       1,222      1,178 
  Foreign exchange reserve                             226        (56)      (140) 
  Retained earnings                               (98,626)    (92,362)   (99,374) 
                                                ----------  ----------  --------- 
 
  Total equity                                      46,720      21,488     34,469 
                                                ==========  ==========  ========= 
 
 
 

Consolidated statement of changes in equity

 
                   Issued     Share      Merger     Reserve   Reserve     Reserve                    Foreign         Retained          Total 
                   Capital   premium    reserve        -      - share        -         Revaluation   exchange         earnings         equity 
                                        - shares     shares    based    convertible      reserve     reserve 
                                         issued       held    payment      loan 
                                           by          in                  note 
                                       subsidiary     EBT 
                 ---------  --------  -----------  --------  --------  ------------  -------------  ---------  --------------------  -------- 
                   GBP'000   GBP'000      GBP'000   GBP'000   GBP'000       GBP'000        GBP'000    GBP'000               GBP'000   GBP'000 
 At 31 December 
  2014                 420    67,750       40,128        67       667         3,652          1,222       (56)              (92,362)    21,488 
                 ---------  --------  -----------  --------  --------  ------------  -------------  ---------  --------------------  -------- 
 
   Exchange 
   differences 
   on 
   translation 
   of foreign 
   operations            -         -            -         -         -             -              -       (84)                     -      (84) 
 Remeasurement 
  of net 
  defined 
  benefit 
  liability              -         -            -         -         -             -              -          -                   205       205 
 Remeasurement 
  of 
  investments 
  - retirement 
  benefit 
  assets                 -         -            -         -         -             -           (44)          -                     8      (36) 
                 ---------  --------  -----------  --------  --------  ------------  -------------  ---------  --------------------  -------- 
 Total other 
  comprehensive 
  income                 -         -            -         -         -             -           (44)       (84)                   213        85 
 Loss for 
  the period 
  after tax              -         -            -         -         -             -              -          -               (7,197)   (7,197) 
                 ---------  --------  -----------  --------  --------  ------------  -------------  ---------  --------------------  -------- 
 Total 
  comprehensive 
  income                 -         -            -         -         -             -           (44)       (84)               (6,984)   (7,112) 
 
   Transactions 
   with 
   shareholders 
   -Convertible 
   loan note             -         -            -         -         -             -              -          -                  (86)      (86) 
 Conversion 
  of loan 
  note to 
  equity                42     3,832            -         -         -       (3,652)              -          -                 (222)         - 
 Share based 
  payments               -         -            -         -       204             -              -          -                     -       204 
 
   Shares 
   issued               94    19,881            -         -         -             -              -          -                     -    19,975 
 Transfer 
  of lapsed 
  options 
  to retained 
  earnings               -         -            -         -     (280)             -              -          -                   280         - 
                 ---------  --------  -----------  --------  --------  ------------  -------------  ---------  --------------------  -------- 
 At 30 June 
  2015                 556    91,463       40,128        67       591             -          1,178      (140)              (99,374)    34,469 
                 ---------  --------  -----------  --------  --------  ------------  -------------  ---------  --------------------  -------- 
 
   Exchange 
   differences 
   on 
   translation 
   of foreign 
   operations            -         -            -         -         -             -              -        366                     -       366 
 Remeasurement 
  of net 
  defined 
  benefit 
  liability              -         -            -         -         -             -              -          -                 (255)     (255) 
 Remeasurement 
  of 
  investments 
  - retirement 
  benefit 
  assets                 -         -            -         -         -             -              -          -                  (51)      (51) 
                 ---------  --------  -----------  --------  --------  ------------  -------------  ---------  --------------------  -------- 
 Total other 
  comprehensive 
  income                 -         -            -         -         -             -              -        366                 (306)        60 
 Profit for 
  the period 
  after tax              -         -            -         -         -             -              -          -                 1,054     1,054 
                 ---------  --------  -----------  --------  --------  ------------  -------------  ---------  --------------------  -------- 
 Total 
  comprehensive 
  income                 -         -            -         -         -             -              -        366                   748     1,114 
 Share based 
  payments               -         -            -         -       170             -              -          -                     -       170 
 
 Shares issued          41    10,926            -         -         -             -              -          -                     -    10,967 
 
 
 At 31 December 
  2015                 597   102,389       40,128        67       761             -          1,178        226              (98,626)    46,720 
                 =========  ========  ===========  ========  ========  ============  =============  =========  ====================  ======== 
 
 
 
 Condensed consolidated cash 
  flow statement 
                                         6 months    6 months      12 months 
                                             to          to            to 
                                           31Dec       31Dec         30Jun 
                                           2015        2014          2015 
                                          GBP'000     GBP'000       GBP'000 
                                         unaudited   unaudited      audited 
                                                                 (as restated) 
 Cash flows from operating 
  activities 
 
 Profit before tax                           1,303       7,413             654 
 
 Adjustments for: 
 Finance income                               (84)         (1)           (147) 
 Finance expense                               154         110             218 
  Non cash movements on defined 
   benefit pension plan                        148         143             290 
  Depreciation and amortisation                782         644           1,293 
  Charge for share based payments              170         202             406 
  Derivative financial instruments             781         183           (438) 
  Foreign exchange revaluation 
   on US Dollar cash deposits              (1,087)           -           1,118 
  (Increase)/decrease in trade 
   and other receivables                   (2,112)     (1,922)           (448) 
  Decrease/(increase) in inventories             2          90           (424) 
  Increase/(decrease) in trade 
   and other payables                          550       (358)           1,079 
                                        ----------  ----------  -------------- 
 
  Net cash generated by operations             607       6,504           3,601 
 
  Interest paid                              (154)       (111)           (304) 
  Income tax received/(paid)                    44           -           (174) 
 
  Net cash generated by operating 
   activities                                  497       6,393           3,123 
 
  Cash flows from investing 
   activities 
  Interest received                             11           1              65 
  Investments                                (128)       (166)           (275) 
  Acquisition of Alerpharma 
   Group                                         -           -         (2,653) 
  Cash acquired on acquisition 
   of Alerpharma Group                           -           -           1,301 
  Payments for intangible assets             (142)        (48)            (13) 
  Payments for property plant 
   and equipment                             (335)       (221)         (1,091) 
 
  Net cash used in investing 
   activities                                (594)       (434)         (2,666) 
 
  Cash flows from financing 
   activities 
  Proceeds from issue of equity 
   shares (net of share issue 
   costs)                                   10,967          34          20,079 
  Repayment of borrowings                    (120)           -               - 
 
  Net cash generated by financing 
   activities                               10,847          34          20,079 
                                        ----------  ----------  -------------- 
 
  Net increase in cash and cash 
   equivalents                              10,750       5,993          20,536 
  Effects of exchange rates 

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March 08, 2016 02:01 ET (07:01 GMT)

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