International stocks trading in New York were mixed on Tuesday. The BNY Mellon index of American depositary receipts rose 0.43% to 139.64. The European index increased 0.67% to 137.42, the Asian index improved 0.25% to 143.40, the Latin American index fell 1% to 228.86 and the emerging markets index eased 0.03% to 266.52. Among the companies with shares that actively traded was SAP SE (SAP, SAP.XE).

SAP on Tuesday dropped its medium-term profit-margin guidance and reported its fourth-quarter profit fell 1%, in the latest sign the German business-software provider's shift from on-premise software to Internet cloud-based products is holding back growth. Shares fell 5.3% to $63.56.

The U.S. Supreme Court on Tuesday reversed an appeals court ruling that invalidated a Teva Pharmaceutical Industries Ltd. (TEVA, TEVA.TV) patent on the blockbuster multiple-sclerosis drug Copaxone, giving the drug maker a new opportunity to forestall generic competition. Shares rose 1.2% to $58.44.

Unilever PLC (UL, ULVR.LN) said weakening demand in emerging markets, especially China, has showed no sign of letting up this year even as the consumer-goods group reported a higher profit for 2014. The maker of Dove soap, Axe deodorant and Hellmann's mayonnaise, has relied heavily on emerging markets to drive growth in the past decade. Shares fell nearly 1% to $41.37.

Write to Tess Stynes at tess.stynes@wsj.com

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