OSI Pharmaceuticals Inc.'s (OSIP) board has rejected Japan drugmaker Astellas Pharma Inc.'s (4503.TO, ALPMY) $3.5 billion takeover bid, saying the $52-a-share price is too low.

Shares were up 1% at $58.25 premarket. Astellas' U.S.-traded shares weren't active premarket after closing Friday at $36.76.

OSI had brushed aside overtures from Astellas for more than a year, also calling them too low, before Japan's second-biggest pharmaceutical company by sales made its hostile-takeover proposal earlier this month.

OSI Chairman Robert A. Ingram said Monday the latest offer fails to "fully reflect OSI's fundamental, intrinsic value." He said OSI is the only profitable, mid-cap biotech company with a growing, high quality and fully integrated oncology franchise and a strong diabetes and obesity franchise, making it a unique asset.

He also said the board "takes its fiduciary duties seriously and will continue to do what's right for OSI stockholders."

Astellas also filed a lawsuit against OSI and its directors when it made its hostile tender offer, seeking to stop them from getting in the offer's way. That included an effort to prevent the board from applying OSI's shareholder rights plan, a so-called poison pill, as Astellas argued that any such move would be "inconsistent with the directors' fiduciary duties."

OSI's only marketed product is cancer drug Tarceva, which it sells with Swiss drug giant Roche Holding AG (ROG.VX, RHHBY). The drug generates more than $1 billion in annual sales. OSI evenly splits U.S. profits from the drug with Roche, but receives royalties on sales outside of the U.S.

-By Joan E. Solsman, Dow Jones Newswires; 212-416-2291; joan.solsman@dowjones.com

 
 
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