By John Kell 
 

Cubist Pharmaceuticals Inc. (CBST) unveiled a pair of deals to acquire two smaller biopharmaceutical peers, transactions that could total a combined $1.6 billion if certain sales milestones are achieved.

In separate press releases, Cubist said it was paying about $535 million to acquire Optimer Pharmaceuticals Inc. (OPTR) and $707 million to buy Trius Therapeutics Inc. (TSRX). The news sent Cubist's shares up 2.6% to $58.50 in after-hours trading.

Trius's shares jumped 20% to $14.10 in after-hours trading, while Optimer's slid 9.6% to $12.02.

In addition to the $10.75-a-share cash offer for Optimer, Cubist says each stockholder of Optimer will receive a right that enables the shareholder to receive an additional one-time cash payment of up to $5 for each share owned.

The additional payment, which would bring the total transaction value to up to $801 million, would depend on if certain sales milestones of Optimer's Dificid, which is a treatment for bacterial-associated diarrhea, are achieved.

The deal for Optimer comes after the company earlier this year said it was exploring a number of strategic options, as part of a larger overhaul of top management at the company. Media reports said Optimer received several first-round offers, including an offer from Cubist.

Cubist and Optimer already have a history, as the companies inked a two-year agreement in April 2011 under which Cubist has been co-promoting Dificid to physicians, hospitals and other health-care institutions in the U.S. Concurrently with the merger agreement, the companies extended the co-promotion agreement for up to one year.

Dificid was launched in the U.S. in July 2011. Sales for the drug totaled $62.4 million in the U.S. and Canada in 2012, up sharply from $21.5 million the prior year. The drug's sales also grew 17% in the first quarter.

The payment tied to the performance of Dificid's sales will take into consideration cumulative net sales of the drug from July 1 of this year through the end of 2015. If, for example, cumulative net sales exceed $300 million, the one-time cash payment would total $5 per share. Cubist and Optimer expect to close the transaction later this year.

Morgan Stanley (MS) is acting as exclusive financial adviser to Cubist, while J.P. Morgan Chase & Co. (JPM) and Centerview Partners LLC are advising Optimer.

For Trius, Cubist said it will buy all outstanding shares for $13.50 in cash, or about $707 million, representing a premium of 15% to Trius's closing price Tuesday. The transaction, expected to close later this year, could be valued at up to $818 million if the company's late-stage antibiotic candidate achieves certain sales milestones.

Cubist said it is expected that a new drug application for the late-stage treatment for some skin infections will be submitted to the U.S. Food and Drug Administration for the second half of 2013. Trius has also already partnered with Bayer AG (BAYN.XE) for the development and commercialization of the treatment in Canada and the European Union.

Barclays PLC (BCS, BARC.LN) has advised Cubist on the Trius deal, while Citigroup Inc. (C) and Centerview are advising Trius.

Write to John Kell at john.kell@wsj.com

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