By Corrie Driebusch 

U.S. stocks rose on Tuesday as a number of positive quarterly earnings reports helped offset a continued decline in the biotechnology sector.

The Dow Jones Industrial Average rose 72.17 points, or 0.4%, to 18110.14, and the S&P 500 gained 5.84 points, or 0.3%, to 2114.76. The Nasdaq Composite fell 4.82 points, or 0.1%, to 5055.42.

Last week, the Nasdaq Composite advanced to a record close for the first time in 15 years, and on Friday, strong corporate results in the technology sector catapulted both the Nasdaq and the S&P 500 into record territory.

Earnings reports were the focus for investors. On Tuesday, 41 companies in the S&P 500, more than 8% of the index, reported quarterly results.

A jump in Merck Co. shares helped lift indexes. Merck raised its earnings guidance for the year as its first-quarter results declined less than expected. Shares rose 5%, adding 19 points to the Dow.

Aetna Inc.'s stock also climbed following its quarterly results. The health insurer's shares added 3.2% as it reported better-than-expected earnings in the latest quarter and boosted its profit outlook for 2015 again on Tuesday.

Apple Inc. said Monday it has sold 61.2 million iPhones in the three months ended March 28, up 40% from the year-ago period. Strong iPhone demand boosted Apple's profit, which increased 33% to $13.57 billion in its fiscal second quarter. Still, shares declined 1.6%, as traders said investors were repositioning their portfolios.

In late Tuesday trading, Twitter Inc. shares fell sharply after the website Selerity reported the company's per-share earnings results in a tweet. Shares were halted and Twitter officially reported its quarterly results, giving downbeat sales guidance for the current quarter and year and saying first-quarter revenue rose less than expected. After reopening, Twitter shares plunged 18%.

Including results from 233 companies in the S&P 500, first-quarter earnings are on track to fall 1.8% from a year earlier. Earnings had been expected to decline 4.6% going into the reporting season, pressured by a strong dollar and weak oil prices. As many companies beat lowered earnings expectations, equities have been trending higher.

"Valuations still don't look unreasonable to us," said Tony Scherrer, director of research at Smead Capital Management, which manages approximately $1.4 billion. Mr. Scherrer said the firm likes consumer discretionary shares in particular. In addition to the average consumer, who Mr. Scherrer believes hasn't yet reached peak spending potential, he believes the sector will benefit from the maturing millennial generation.

"There's an entire generation out there that hasn't come into their own in terms of spending and household formation," he said.

On Tuesday, the Nasdaq Biotechnology index fell 1.2%. So far this week it is down 5.2%. The biotech sector has outpaced broader market gains this year. Through Friday's close, the Nasdaq Biotechnology index was up about 20% for the year. The Nasdaq had rallied 7.5% through Friday's market close, while the S&P 500 had added 2.9%.

"[Biotech] has been trading on an incredible multiple and everybody owns it," said Mr. Winer, adding that it is tough to point to any fundamental changes in the sector, and that the declines in biotech stocks so far this week are "a normal drawdown."

Some traders said investors were eagerly awaiting coming macroeconomic events, including the Federal Reserve's two-day policy meeting which begins Tuesday. While there is no news conference scheduled following the meeting and economists don't expect major changes to the policy statement, traders will be carefully parsing the statement, which will be released Wednesday, for any mentions of a stronger U.S. dollar and global growth.

In commodity markets, gold futures rose 0.9% to $1214.00 an ounce. Crude-oil futures added 0.1% to $57.06 a barrel.

Write to Corrie Driebusch at corrie.driebusch@wsj.com

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