By Dana Mattioli, Jonathan D. Rockoff, Dana Cimilluca and Liz Hoffman 

Israeli drug maker Teva Pharmaceutical Industries Ltd. is in talks to combine with Allergan PLC's big generic-drug business, in a move that would further consolidation in the health-care industry and likely mean the end of Teva's pursuit of another acquisition.

A deal for the Allergan business, valued at about $45 billion, could be announced as early as Monday, according to people familiar with the matter. The Allergan unit would be spun off and combined with Teva--already the world's biggest seller of generic medicines with a market value of $60 billion--one of the people said.

Teva has been seeking to buy Mylan NV, a deal Mylan has been resisting as it pursues fellow drug maker Perrigo Co. PLC.

The merger would be the latest to shake up a major sector of the health-care industry, and come on the heels of two big announcements in which four of the largest managed-care companies-- Anthem Inc. and Cigna Corp. and Aetna Inc. and Humana Inc. --agreed to combine into two companies, in deals worth a combined $82 billion.

Companies of all stripes are scrambling for tie-ups following the Supreme Court's decision last month that upheld the 2010 Affordable Care Act health-care overhaul. Teva and Allergan, one of the most active acquires in any industry in recent years, would be the latest example of companies consolidating in part to achieve the health savings sought by policy makers.

For Teva, a deal with Allergan would largely give the company what it has been seeking from a Mylan deal: increased scale in the hotly competitive generic-drug market, and an opportunity to pursue further cost reductions that could help it cope with razor-thin margins on the low-priced medicines.

Teva is under pressure because its top selling product, a brand-name multiple-sclerosis treatment called Copaxone, started facing lower-priced competition in the U.S. last month.

The $70 billion-a-year generic-drugs business isn't growing like it had been, now that most of the big patent expirations for blockbuster brand-name drugs such as cholesterol fighter Lipitor have passed. In addition, the big generic-drug companies are facing new rivals from India and other countries that are competing on price.

As a result, some generic-drug companies including Allergan have been moving upmarket into lucrative brand-name drugs. Actavis was renamed Allergan earlier this year, after doing $100 billion in deals last year that gave it brand-name drugs, notably wrinkle fighter Botox.

But the deal making had swollen Allergan's debt to about $44.3 billion as of March 31. A deal with Teva would help Allergan pay down its debt and, combined with the $8 billion-a-year it generates in cash, add higher-profit prescription drugs.

Terms of the Teva deal are still being worked out, including whether Allergan's drug-distribution business will be a part of deal, according to one of the people familiar with the talks. That operation currently generates about $462 million in net revenue a quarter.

Allergan's generics business was Teva's first choice for a big deal, according to the person.

Last year, Allergan was the world's third-largest seller of generic drugs after Teva and Novartis AG--with $6.6 billion in sales, according to EvaluatePharma. Teva had $9.1 billion in generic-drug sales, about 12% of the world market.

Allergan's 1,000 low-priced products include branded generic drugs, over-the-counter medicines and generic versions of well-known brand names such as the OxyContin pain treatment and the Concerta attention-deficit-hyperactivity-disorder drug, according to the company website.

The chief executive of Teva's global generic-medicines group, Sigurdur Olafsson, knows the Allergan generics business since he had worked there until 2014.

According to the person, a few months after Erez Vigodman took the helm of Teva in February 2014, the company reached out to what was then Actavis about a deal. But at that time, Actavis wasn't interested in selling its generics business and dismissed the interest.

Teva discussed a deal with Actavis a few times, the person said, before The Wall Street Journal reported in April that the Israeli company was considering a bid for Mylan.

Teva has been building up a 4.6% stake in Mylan, but Mylan's resistance has been fierce. On Thursday, a foundation set up by Mylan triggered a kind of Dutch poison pill, designed to thwart any combination.

By that time, Teva was already in serious discussions with Allergan about their own deal. Teva had upped its offer, and Allergan was open to shedding its generics business, the person said.

Allergan's market value on Friday stood at $124 billion.

Should shareholders react positively to any deal announcement between the companies--as they have in many such cases lately-- among those benefiting could be Glenview Capital Management LLC. The hedge fund was recently building a stake in Allergan, after reaping more than $3 billion on a big bet on health-care stocks in recent years.

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