By Angela Chen 

Mylan NV raised its offer to buy generic drug maker Perrigo Co. to about $33 billion, the latest move in a three-way takeover tussle in the pharmaceutical industry.

Mylan, which saw an earlier offer spurned by Perrigo this week, said its latest bid consists of $60 in cash and 2.2 Mylan shares for each share of Perrigo. Based on Thursday's close, the offer values Perrigo at about $222 a share. That's up from Mylan's earlier approach of $205 in an unspecified mix of cash and stock.

Perrigo's shareholders showed disappointment with the new offer, however, sending its shares down 3.2% to $195.15 in recent trading. That's likely because Mylan shares have surged since the company received its own $40 billion takeover approach from Teva Pharmaceutical Industries Ltd., and its new bid for Perrigo doesn't fully reflect those gains.

Mylan shares edged up 2.1% to $75.24 and are up 27% so far this month.

Perrigo has thus far rejected Mylan's advances, and Mylan has spurned Teva. A representative for Perrigo declined to comment Friday, and a spokesperson for Teva said the company remains "fully committed" to its offer for Mylan.

Teva shares gained 1.5% to $64.21.

The three-way fight underscores the deal-making surge that is under way in an industry grappling with slowing growth. At the heart of the frenzy is a quest for new revenue amid pricing pressure from cash-strapped governments and insurers, and increased competition.

Mylan and Perrigo generally compete in different segments of the generic-drug business. Mylan is best known for selling generic prescription drugs, though its top-selling product is the EpiPen emergency treatment for allergic reactions. Perrigo makes over-the-counter cough-and-cold remedies and infant formula for chains like Wal-Mart Stores Inc. and Walgreens, which sell the products under their own names.

Neither company is a household name, but a combination of Mylan and Perrigo would create one of the world's top sellers of low-price medicines with $15.3 billion in yearly sales.

Mylan said its nonbinding offer is fully financed, cash confirmed and not conditional on due diligence. The company estimated its investors would own about 62% of the combined company's shares, with Perrigo's holders owning the remaining 38%. It added the deal should result in at least $800 million in synergies by the end of the fourth year after the deal closes.

Under takeover rules in Ireland, where Perrigo is based, Mylan is obligated to make a public announcement once it has started the formal process of acquiring another company.

Meanwhile, a merger of Mylan and Teva--an Israeli company that says its medicines account for one out of every eight prescriptions in the U.S.--would create the world's top-selling generic-drug company with more than $30 billion in sales in 145 countries.

Teva, known for its Copaxone multiple-sclerosis drug, has said it is a natural fit with Mylan and the scale of the combined company would help it better manage costs in the low-margin generics business. It added a tie-up would bolster its ability to develop low-price knockoffs of biotech drugs, a new market that offers the potential for significant growth.

Write to Angela Chen at angela.chen@dowjones.com

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