Among the companies with shares expected to actively trade in Friday's session are Santarus Inc. (SNTS) and AVG Technologies NV (AVG).

Salix Pharmaceuticals Ltd. (SLXP) agreed to pay roughly $2.15 billion to acquire specialty pharmaceutical company Santarus, a deal the buyer said will boost earnings in 2014 and expand its pipeline. The per-share price Salix agreed to pay, $32, represented a 38% premium over Santarus's closing price Thursday. Shares of Santarus, which went public in 2004, jumped 37% to $31.87 in premarket trading, and Salix was up 11% to $79.20.

AVG's third-quarter earnings declined 75%, with a higher tax provision and thinner operating margins weighing on results. Shares were down 13% at $17.10 in premarket trading as the company lowered its revenue outlook for the year and issued downbeat guidance for the fourth quarter.

Alcoa Inc. (AA) unveiled its business targets for the next three years as Chairman and Chief Executive Klaus Kleinfeld said the aluminum company has made "significant strides" in repositioning its business. Shares edged up 1.3% to $9.07 premarket.

Allscripts Healthcare Solutions Inc. (MDRX) swung to a third-quarter loss on transaction-related costs and other one-time items, but the electronic health-records company also reported sharp growth in bookings from a year earlier. Shares were up 5.4% at $14.95 in recent after-hours trading.

Gap Inc. (GPS) reported better-than-expected fiscal third-quarter sales growth, results that benefited from a strong showing in October. The company's stock jumped 7.7% to $40.65 in after-hours trading, as the apparel retailer also provided a rosy earnings outlook for the quarter.

Groupon Inc. (GRPN) posted a wider third-quarter loss and sales below expectations. But it also said it is testing a version of its website that wouldn't require an email address and account to look at deals. That could potentially expand the number of customers it reaches because it would eliminate the need to get daily emails and unveiled plans to buy Korean e-commerce firm Ticket Monster for up to $260 million. Shares climbed 5% to $9.97 premarket.

Horizon Pharma Inc. (HZNP) smashed analysts' estimates as the biopharma company saw revenue from its Duexis arthritis double again sequentially. Prescriptions rose 18% and price increases aided the top line as well. Shares rose 13% to $4.21 premarket.

Lions Gate Entertainment Corp.'s (LGF) fiscal second-quarter profit declined 99% as the company logged an increase in charges for the early extinguishment of debt and as it faced a tough comparison from the year-earlier home entertainment release of "The Hunger Games." The bottom-line results beat views, and shares edged up 1.4% to $32.60 premarket.

Nvidia Corp.'s (NVDA) fiscal third-quarter earnings fell 43% as the chip maker posted weaker revenue and was hit by higher costs. Adjusted earnings declined less than expected, and the company raised its quarterly dividend. Shares rose 1.8% to $14.80 premarket.

Priceline.com Inc. (PCLN) replaced its longtime chief executive with the boss of its most profitable hotel-booking unit, ending an 11-year tenure that oversaw one of the most dramatic turnarounds of the past decade. Quarterly results beat the company's August outlook. Shares edged up 1.8% to $1,041.12 premarket.

Walt Disney Co.'s (DIS) fiscal fourth-quarter profit rose 12% thanks in large part to revenue growth across its segments, but the company pushed back the expected release date of the new installment in the "Star Wars" franchise. Shares edged down 1.4% to $66.20 premarket.

 
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CareFusion Corp.'s (CFN) fiscal first-quarter earnings fell 7.1% as the medical-equipment company's revenue slipped, with declines in its medical systems segment offsetting growth in its procedural solutions business.

Covidien PLC's (COV) fiscal fourth-quarter earnings fell 19% as the company recorded an increase in expenses and a slight decline in medical-supplies sales, while core earnings improved and just topped estimates.

Ensign Group Inc. (ENSG) said it plans to spin off its real-estate business into a separate, publicly traded company. After the split, expected to be completed in the first quarter of next year, the two companies will be Ensign Group, which will focus on health-care services, and CareTrust REIT Inc., which will buy, own and lease real estate for the health-care industry.

International Business Machines Corp. (IBM) appointed insider Martin Schroeter to the chief financial officer role, succeeding Mark Loughridge, as the latter executive will reach Big Blue's customary retirement age next month.

McDonald's Corp.'s (MCD) global same-store sales grew 0.5% in October, with results in the U.S. and Europe offsetting weakness in Asia. McDonald's last month predicted sales to be relatively flat, despite what should have been an easy comparison from a year ago, when the company reported its first monthly same-store sales decline in nine years.

Molycorp Inc.'s (MCP) third-quarter loss widened on a double-digit decline in revenue, though the rare-earth mining company also trimmed costs and saw some sequential improvement.

Pfizer Inc. (PFE) said its organ-transplant drug Rapamune drug didn't meet its primary endpoint in a late stage study of kidney transplant patients. Pfizer said there was no statistically significant difference in renal function improvement between patients who continued receiving tacrolimus-based therapy and those who switched to Rapamune.

E.W. Scripps Co. (SSP) swung to a third-quarter loss as the newspaper and television company was hurt by a loss of political advertising revenue because of the off-year for elections. Results missed estimates.

Write to Lauren Pollock at lauren.pollock@wsj.com

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