By Chelsea Stevenson
Biogen Idec Inc. (BIIB) and Isis Pharmaceuticals Inc. (ISIS)
entered into an agreement to develop and commercialize an antisense
drug to treat Steinert disease, a deal that could see Isis receive
more than $271 million.
Steinert disease, formally known as Myotonic dystrophy type 1,
is a form of muscular dystrophy in adults and is often genetic. It
is characterized by progressive weakness and disabling muscle
spasms, which can prevent protein production and cause problems
with breathing and walking.
Isis is responsible for the discovery of the drug and the
treatment. The antisense technology company will receive an upfront
payment of $12 million, with the eligibility to receive $59 million
more in milestone payments prior to licensing. It could see an
added $200 million in licensing fees.
Biogen Idec will be responsible for advice on the design of the
Phase II trial and could assume commercialization responsibilities,
upon completion of the trial.
"The unmet need is great, and there are currently no therapies
to slow or stop progression of the disease," said Steven H.
Holtzman, Biogen executive vice president of corporate development
at Biogen Idec.
In May, Isis recorded an increase in revenue for its first
quarter, as it submitted an application to the Food and Drug
Administration for new drug for patients with cardiovascular
disease, Kynamro. The drug would be the company's first important
commercial asset.
Meanwhile, Biogen Idec's first-quarter earnings rose 2.8%,
missing Wall Street expectations after the company's flagship drug
ran into a temporary wholesale purchasing slowdown in the U.S.
Sales for other products were also nicked by a voluntary recall,
though its experimental pill for multiple sclerosis could hit the
market early next year, making its product pipeline a big
focus.
Isis shares were up 2.9% to $11.98 in recent premarket trading.
Shares closed Thursday at $140.11 for Biogen Idec. The stock
markets are up 27% and 28% respectively over the last 12
months.
Write to Chelsea Stevenson at chelsea.stevenson@dowjones.com